Voltage Gated Potassium Channels
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| Author | : Derek J. Chadwick |
| Publisher | : John Wiley & Sons |
| Total Pages | : 308 |
| Release | : 2005-06-14 |
| Genre | : Science |
| ISBN | : 0470021411 |
Download The hERG Cardiac Potassium Channel Book in PDF, Epub and Kindle
This book draws together contributions from basic, pharmaceutical and clinical sciences aimed at a better understanding of the structure and function of hERG and the molecular basis for compound binding. It features regulatory authority perspectives on preferred preclinical test systems and includes topics on hERG channel gating, regulation of functional expression, pharmacological properties of hERG/IKr channels, drug-induced long QT syndrome and preclinical evaluation and regulatory recommendations for assessing QT prolongation risks. Better understanding of the role of the hERG channel in drug-induced cardiac arrhythmias should ultimately lead to the development of important, new and safer medicines.
| Author | : Bruce Alberts |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 2002 |
| Genre | : Cytology |
| ISBN | : 9780815332183 |
Download Molecular Biology of The Cell Book in PDF, Epub and Kindle
| Author | : Nikita Gamper |
| Publisher | : Springer Nature |
| Total Pages | : 546 |
| Release | : 2021-09-27 |
| Genre | : Medical |
| ISBN | : 3030840522 |
Download Pharmacology of Potassium Channels Book in PDF, Epub and Kindle
The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.
| Author | : David J. Triggle |
| Publisher | : John Wiley & Sons |
| Total Pages | : 492 |
| Release | : 2006-08-21 |
| Genre | : Science |
| ISBN | : 3527607749 |
Download Voltage-Gated Ion Channels as Drug Targets Book in PDF, Epub and Kindle
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
| Author | : Peter C. Ruben |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 328 |
| Release | : 2014-04-15 |
| Genre | : Medical |
| ISBN | : 3642415881 |
Download Voltage Gated Sodium Channels Book in PDF, Epub and Kindle
A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
| Author | : Jie Zheng |
| Publisher | : CRC Press |
| Total Pages | : 682 |
| Release | : 2015-02-25 |
| Genre | : Medical |
| ISBN | : 1466551429 |
Download Handbook of Ion Channels Book in PDF, Epub and Kindle
The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
| Author | : Wulfram Gerstner |
| Publisher | : Cambridge University Press |
| Total Pages | : 591 |
| Release | : 2014-07-24 |
| Genre | : Computers |
| ISBN | : 1107060834 |
Download Neuronal Dynamics Book in PDF, Epub and Kindle
This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
| Author | : Craig Dustin Patten |
| Publisher | : |
| Total Pages | : 236 |
| Release | : 1998 |
| Genre | : |
| ISBN | : |
Download Structure and Function of Voltage Gated Potassium Channels Book in PDF, Epub and Kindle
| Author | : Jeffrey Noebels |
| Publisher | : OUP USA |
| Total Pages | : 1258 |
| Release | : 2012-06-29 |
| Genre | : Medical |
| ISBN | : 0199746540 |
Download Jasper's Basic Mechanisms of the Epilepsies Book in PDF, Epub and Kindle
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
| Author | : Shin-Ho Chung |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 657 |
| Release | : 2007-11-13 |
| Genre | : Science |
| ISBN | : 0387689192 |
Download Biological Membrane Ion Channels Book in PDF, Epub and Kindle
This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
