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Abstract: The proper balance and interactions of nutrients in the human body are the subjects of ongoing studies; a review of literature in these fields for 1977 is presented, covering deficiencies, metabolism, animal and human studies, toxicity and megadoses, requirements, bioavailability, etc. Nutrients investigated are vitamins A, D, E, and C; thiamine, riboflovin, pyridoxine, folic acid and vitamin B 12; and trace elements such as zinc, copper, iron, chromium and cobalt. Information is drawn from over 700 published articles.