Tumour Associated Macrophages
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Author | : Barrett Rollins |
Publisher | : Springer Science & Business Media |
Total Pages | : 346 |
Release | : 1999 |
Genre | : Medical |
ISBN | : |
Download Chemokines and Cancer Book in PDF, Epub and Kindle
Since the introduction of microscopy, pathologists have noted tumor infiltration by inflammatory cells and presumed that this represents the host's attempt to reject its tumor. Recent advances in the molecular biology of inflammation have revealed the signals involved in attracting inflammatory cells to tumors and, for the most part, these signals are mediated by chemokines and their receptors. Chemokines are low molecular weight proteins that attract and activate specific subsets of leukocytes to the exclusion of others.
Author | : Toby Lawrence |
Publisher | : Springer Science & Business Media |
Total Pages | : 189 |
Release | : 2011-10-06 |
Genre | : Medical |
ISBN | : 1461406625 |
Download Tumour-Associated Macrophages Book in PDF, Epub and Kindle
The subject of Tumour-Associated Macrophages is of interest in the cancer research community, and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development.
Author | : |
Publisher | : |
Total Pages | : 200 |
Release | : 2011-10-06 |
Genre | : |
ISBN | : 9781461406631 |
Download Tumour-Associated Macrophages Book in PDF, Epub and Kindle
Author | : Mariano Bizzarri |
Publisher | : Springer Nature |
Total Pages | : 493 |
Release | : 2020-04-17 |
Genre | : Medical |
ISBN | : 3030328570 |
Download Approaching Complex Diseases Book in PDF, Epub and Kindle
This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Author | : Bernd Kaina |
Publisher | : Frontiers Media SA |
Total Pages | : 129 |
Release | : 2023-06-01 |
Genre | : Medical |
ISBN | : 2832524680 |
Download The role of tumor-associated macrophages in tumor progression Book in PDF, Epub and Kindle
Author | : Robert C. Rees |
Publisher | : Oxford University Press, USA |
Total Pages | : 469 |
Release | : 2014 |
Genre | : Medical |
ISBN | : 0199676860 |
Download Tumor Immunology and Immunotherapy Book in PDF, Epub and Kindle
Tumor immunology and immunotherapy provides a comprehensive account of cancer immunity and immunotherapy. Examining recent results, current areas of interest and the specific issues that are affecting the research and development of vaccines, this book provides insight into how these problems may be overcome as viewed by leaders in the field.
Author | : Magdalena Klink |
Publisher | : Springer Nature |
Total Pages | : 358 |
Release | : 2022-02-14 |
Genre | : Medical |
ISBN | : 3030913112 |
Download Interaction of Immune and Cancer Cells Book in PDF, Epub and Kindle
Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.
Author | : Derek J. Chadwick |
Publisher | : John Wiley & Sons |
Total Pages | : 312 |
Release | : 2004-03-05 |
Genre | : Medical |
ISBN | : |
Download Cancer and Inflammation Book in PDF, Epub and Kindle
Chronic inflammation predisposes to some forms of cancer and the host response to malignant disease shows several parallels with inflammation and wound healing. The cells involved in inflammation are detected in a range of common cancers, together with the inflammatory cytokines and members of the chemokine ligand/receptor systems. Neutralization or deletion of the gene for some inflammatory cytokines confers resistance to tumour induction and experimental metastasis. Over-expression of such cytokines in tumour cells may enhance malignant potential. Certain chemokines are likely to subvert antitumour immunity by favouring development of ineffective Type 2 responses. Tumour cells may even utilize chemokine receptors in homing to lymph nodes and other organs. Thus, the cells, cytokines and chemokines found in tumours are more likely to contribute to tumour growth, progression and immunosuppression than they are to mount an effective host antitumour response. This book draws together contributions from an international group of scientists and clinicians from diverse disciplines, ranging from epidemiology to immunology, cell biology, molecular oncology, molecular medicine and pharmacology to debate these and related issues. Topics covered include the epidemiological links between cancer and inflammation, the parallels between inflammation and cancer, the role of inflammation in cancer, inflammatory genes as risk factors for cancer initiation and progression, inflammation and cancer angiogenesis, and preventative and therapeutic strategies. Related Novartis Foundation symposia: 252 Generation and effector functions of regulatory lymphocytes Chair: Jean-François Bach Immunoinformatics: bioinformatic strategies for better understanding of immune function Chair: Hans-Georg Rammensee
Author | : Sam Thiagalingam |
Publisher | : Cambridge University Press |
Total Pages | : 597 |
Release | : 2015-04-09 |
Genre | : Mathematics |
ISBN | : 0521493390 |
Download Systems Biology of Cancer Book in PDF, Epub and Kindle
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Author | : Giovanni Natile |
Publisher | : MDPI |
Total Pages | : 177 |
Release | : 2018-03-05 |
Genre | : Science |
ISBN | : 3038427578 |
Download Translocator Protein (TSPO) Book in PDF, Epub and Kindle
This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS