The theme of this volume is the American relationship with Macao and its region through trade, politics and culture, and the focus is mainly on the late 18th and 19th centuries. The essays address topics such as the role of the China trade in US pacific expansion and exploration, US consuls, smuggling networks, missionary and educational work, and American women's perceptions of China. In all of the encounters, Macao emerges as a central player, adding a new dimension to our understanding of Sino-American relations.