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| Author | : Rodolfo Riascos Llinás |
| Publisher | : Oxford University Press, USA |
| Total Pages | : 234 |
| Release | : 1999 |
| Genre | : Neural transmission |
| ISBN | : 9780195116526 |
Ideal for graduate and undergraduate courses, the book includes PC and Macintosh versions of two programs for simulating and manipulating any aspect of synaptic transmission."--BOOK JACKET.
| Author | : Ronald Wayne Joyner |
| Publisher | : |
| Total Pages | : 312 |
| Release | : 1973 |
| Genre | : Electrophysiology |
| ISBN | : |
| Author | : Rodolfo Riascos Llinas |
| Publisher | : |
| Total Pages | : 224 |
| Release | : 1999 |
| Genre | : Cephalopoda |
| ISBN | : 9780195116526 |
| Author | : Sanford M. Simon |
| Publisher | : |
| Total Pages | : 448 |
| Release | : 1984 |
| Genre | : |
| ISBN | : |
| Author | : Robert S.. Zucker |
| Publisher | : |
| Total Pages | : 43 |
| Release | : 1991 |
| Genre | : |
| ISBN | : |
| Author | : W.J., Jr. Adelman |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 531 |
| Release | : 2013-06-29 |
| Genre | : Science |
| ISBN | : 1489924892 |
The predecessor to this book was A Guide to the Laboratory Use of the Squid Loligo pealei published by the Marine Biological Laboratory, Woods Hole, Massachusetts in 1974. The revision of this long out of date guide, with the approval of the Marine Biological Laboratory, is an attempt to introduce students and researchers to the cephalopods and particularly the squid as an object of biological research. Therefore, we have decided to expand on its original theme, which was to present important practical aspects for using the squid as experimental animals. There are twenty two chapters instead of the original eight. The material in the original eight chapters has been completely revised. Since more than one method can be used for accomplishing a given task, some duplication of methods was considered desirable in the various chapters. Thus, the methodology can be chosen which is best suited for each reader's requirements. Each subject also contains a mini-review which can serve as an introduction to the various topics. Thus, the volume is not just a laboratory manual, but can also be used as an introduction to squid biology. The book is intended for laboratory technicians, advanced undergraduate students, graduate students, researchers, and all others who want to learn the purpose, methods, and techniques of using squid as experimental animals. This is the reason why the name has been changed to its present title. Preceding the chapters is a list of many of the abbreviations, prefixes, and suffixes used in this volume.
| Author | : Milton Peter Charlton |
| Publisher | : |
| Total Pages | : 0 |
| Release | : 1976 |
| Genre | : Neural transmission |
| ISBN | : |
"Successive action potentials in a pre-synaptic axon terminal often evoke responses of increasing amplitude in the post-synaptic cell. This phenomenon, called facilitation, is of interest to physiologists for several reasons. [...] Facilitation at the squid giant synapse has been noted by other workers but has not been extensively quantified [....] In the present experiments, solutions of low calcium concentrations were used to reduce transmitter release to subthreshold levels and to enhance the detection of facilitation. I have shown that the magnitude, time course of decay and summation of facilitation are similar in squid and other animals. This result lends generality to findings in the squid concerning the mechanism of facilitation discussed in this and the following chapter. [...] Various hypotheses for the mechanism of facilitation involve changes in major factors governing transmitter release such as pre-synaptic depolarization and the availability of calcium ions. [...] In order to test these hypotheses, it is necessary to directly measure and modify these parameters in the pre-synaptic terminal. I chose the squid giant synapse to study facilitation because its extremely large size enables one, by placing microelectrodes directly in the pre-synaptic terminal, to measure and manipulate some of the above variables (Takeuchi and Takeuchi, 1962; Miledi, 1973; Llinas and Nicholson, 1975). This preparation was used to test the residual-calcium hypothesis by altering extracellular calcium concentration and temperature, and to test the membrane-potential hypotheses by recording and manipulating presynaptic membrane potentials"--Leaves 1-3
| Author | : Yigal H. Ehrlich |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 553 |
| Release | : 2013-03-13 |
| Genre | : Science |
| ISBN | : 1468476181 |
The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
| Author | : |
| Publisher | : Academic Press |
| Total Pages | : 613 |
| Release | : 1984-06-30 |
| Genre | : Science |
| ISBN | : 0080584934 |
Current Topics in Membranes and Transport
| Author | : R. Tapia |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 421 |
| Release | : 2012-12-06 |
| Genre | : Medical |
| ISBN | : 1468439685 |
This book, which originated in the presentations of a symposium sponsored by the Universidad Nacional Autonoma de Mexico, held in Mexico City on April 14-16, 1980, represents an attempt to analyze some of the most relevant aspects of synaptic transmission. This topic was chosen on the strong belief that the progress of the neurosciences depends to a great extent on the understanding of the basic mechanisms of synaptic function. Rather than selecting only a specific approach or speciality, the book intends to cover this field in a multi disciplinary way. This means that neurochemical, neurophysiological and morphological studies are mingled throughout the book, which hopefully will help the reader to integrate the different faces of the same problem. Across the book the presynaptic component of synaptic transmission and its regulation is stressed much more than the postsynaptic phenomena. Although this might be a limitation, it has the advantage of increasing the focus of the book on a series of events which are gaining importance and interest every day.
