The study of late Pliocene and Early Pleistocene archaeological sites in East Asia can help to solve the question of when hominins first left Africa and how they might have settled in Asia. Some earliest hominin evidences in China were not generally accepted mainly due to chronological uncertainty, since most of them are beyond the classic radioisotopic dating range and lack of volcanic materials for K-Ar and Ar-Ar dating. Combined ESR/U-series dating could solve this problem, as its application on fossil tooth has a potential to date the sites older than 1 Ma, depending however on the accuracy of reconstructing uranium uptake history. An U-diffusion parameter p should be defined for each dental tissue and the obtained US-ESR model age is less uncertain than the conventional EU (early uptake) and LU (linear uptake) ESR model ages. In this work, combined ESR and U-series dating method of fossil tooth has been attempted to date two Early Pleistocene sites of China, Longgupo and Donggutuo. This study shows that this combined method provides the availability of dating the old archaeological sites, but some challenges also bring forward. One of the main problems for both sites is the paleodose determination. Comparison analysis shows that double saturation exponential fitting has systematically less deviation with the experimental dose points than the conventional single saturation exponential fitting. Besides, another difficulty of dating Longgupo site lies on the reconstruction of external gamma dose rate, which takes a great contribution (more than 50%) to the total dose rate. Since the inhomogeneous character of the deposition on Longgupo site, the in situ gamma dose rate plays a key role on the final results, and this lead us to revisit the site in order to make a more precise and detailed measurement. Lastly, the study of Donggutuo site shows the most challenge of dating the ancient open sites: uranium leaching of the tooth sample, which cannot be solved by one diffusion parameter US-ESR model and makes the age calculation impossible with this model. Although the challenges of dating the old fossil samples with combined ESR/U-series methods, this study presents a probability of its application on dating Chinese early Pleistocene sites and the result of this study places the age of Longgupo site between 1.3 and 1.7 Ma. With respect to the techniques development of the stone artifacts unearthed from the site, Longgupo is still the earliest evidence of human settlement in southern China.