This play is a sequel to the romantic comedy Antonio and Mellida. Unlike its predecessor, however, Antonio's Revenge is a revenge tragedy. Antonio and Mellida ended with a scene in which the two lovers were reconciled, with the villain, Mellida's father, Duke Piero, apparently repenting his attempts to keep them apart. Antonio's Revenge begins where the previous play ended. It is revealed that Piero has not really reformed: he still hates Antonio, and is determined to prevent his daughter's marriage to him. Piero murders and imprisons various characters, driving Mellida herself to die of grief, before Antonio teams up with other wronged individuals to carry out a revenge on the wicked Duke, which they do through a masque in the play's last act.