Janeway's Immunobiology

Janeway's Immunobiology
Author: Kenneth Murphy
Publisher: Garland Science
Total Pages:
Release: 2010-06-22
Genre: Medical
ISBN: 9780815344575

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The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

The HLA Complex in Biology and Medicine

The HLA Complex in Biology and Medicine
Author: Narinder K Mehra
Publisher: Boydell & Brewer Ltd
Total Pages: 616
Release: 2010-11-26
Genre: Medical
ISBN: 9788184488708

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A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

MHC Protocols

MHC Protocols
Author: Stephen H. Powis
Publisher: Springer Science & Business Media
Total Pages: 343
Release: 2008-02-05
Genre: Medical
ISBN: 1592592910

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The aim of MHC Protocols is to document protocols that can be used for the analysis of genetic variation within the human major histocompatibility complex (MHC; HLA region). The human MHC encompasses approximately 4 million base pairs on the short arm of chromosome 6 at cytogenetic location 6p21. 3. The region is divided into three subregions. The telomeric class I region contains the genes that encode the HLA class I molecules HLA-A, -B, and -C. The centromeric class II region contains the genes encoding the HLA class II molecules HLA-DR, -DQ, and -DP. In between is the class III region, originally identified because it contains genes encoding components of the complement pathway. The entire human MHC has recently been sequenced (1) and each subregion is now known to contain many other genes, a number of which have immunological functions. The study of polymorphism within the MHC is well established, because the region contains the highly polymorphic HLA genes. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. As a result, large numbers of HLA alleles have been identified, a process that has been further driven by recent interest in HLA gene diversity in ethnic populations. The extreme genetic variation in HLA genes is believed to have been driven by the evolutionary response to infectious agents, but relatively few studies have analyzed associations between HLA genetic variation and infectious disease, which has been difficult to demonstrate.

Major Histocompatibility Complex

Major Histocompatibility Complex
Author: M. Kasahara
Publisher: Springer Science & Business Media
Total Pages: 574
Release: 2013-11-11
Genre: Medical
ISBN: 4431658688

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Every biological system is the outcome of evolution and has a history all its own. This history dictates how the system works and why it has certain properties and not others. This is why we need to study not only the structure and function, but also the history of the system. This argument undoubtedly applies to the study of the immune system and also to the study of the major histocompatibility complex (MHC). Since 1989, researchers of various scientific disciplines who share a deep inter est in MHC evolution have held a meeting every two years to discuss their latest research developments, exchange ideas, and foster friendship. Together with my colleagues Drs. Naoyuki Takahata and Yoko Satta, I organized the Sixth Interna tional Workshop on MHC Evolution in Hayama, Japan, May 25-29, 1999. This volume is the proceedings of that conference. It covers diverse topics pertinent to MHC evolution, including the origin of the adaptive immune system, the organi zation of the MHC in humans and other model vertebrates, MHC-parasite co evolution, and the nature and origin of MHC polymorphism. I hope that this book will be of interest not only for MHC researchers and immunologists, but also for other specialists who are interested in the evolution of biological systems in gen eral.

Major Histocompatibility Complex (MHC) in Health and Disease

Major Histocompatibility Complex (MHC) in Health and Disease
Author: Jerzy K. Kulski
Publisher: MDPI
Total Pages: 374
Release: 2020-01-15
Genre: Science
ISBN: 3039280724

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The major histocompatibility complex (MHC) is a highly polymorphic and diverse multigene locus in all jawed vertebrate species that has an integral role in adaptive/innate immune systems, transplantation, and infectious and autoimmune diseases. The MHC supra-locus in mammalian vertebrates is usually partitioned into three distinct regions, known as classes I, II, and III, which, to varying extents, can be found conserved in nonmammalian jawed vertebrates, such as bony fish, amphibians, and bird lineages. The MHC gene region is characterized particularly by the expression of class I and class II glycoproteins that bind peptides derived from intracellular or extracellular antigens to circulating T-cells. While this expressed antigenic specificity remains the predominant interest with respect to MHC function and polymorphism in a population, a broader concept has emerged that examines the MHC as a multifunctional polymorphic controller that facilitates and regulates genome diversity with a much greater array of functions and effects than just MHC-restricted antigen recognition. This volume of 19 reprints presented by various experts and collected from the Special Issue of Cells on “MHC in Health and Disease” covers a broad range of topics on the genomic diversity of the MHC regulatory system in various vertebrate species, including MHC class I, II, and III genes; innate and adaptive immunity; neurology; transplantation; haplotypes; infectious and autoimmune diseases; fecundity; conservation; allelic lineages; and evolution. Taken together, these articles demonstrate the immense complexity and diversity of the MHC structure and function within and between different vertebrate species.

HLA and MHC

HLA and MHC
Author: Michael J. Browning
Publisher: Taylor & Francis
Total Pages: 472
Release: 1996
Genre: Medical
ISBN:

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This is a review of the major histocompatibility complex (MHC), and the role it plays in the immune response and in disease. The emphasis throughout is on the human MHC, but relevant animal studies are inclded to give a comprehensive review of the subject.

Laposata's Laboratory Medicine Diagnosis of Disease in Clinical Laboratory Third Edition

Laposata's Laboratory Medicine Diagnosis of Disease in Clinical Laboratory Third Edition
Author: Michael Laposata
Publisher: McGraw Hill Professional
Total Pages: 592
Release: 2019-01-04
Genre: Medical
ISBN: 1260116808

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The acclaimed full-color guide to selecting the correct laboratory test and interpreting the results –- covering ALL of clinical pathology A Doody’s Core Title for 2019! Laboratory Medicine is the most comprehensive, user-friendly, and well-illustrated guide available for learning how to order the correct laboratory test and understand the clinical significance of the results. The book features an easy-to-follow, consistent presentation for each disease discussed. Chapters begin with a brief description of the disorder followed by a discussion that includes tables detailing the laboratory evaluation of specific disorders, diagnosis, baseline tests to exclude diagnostic possibilities, and clinical indications that warrant further screening and special testing. With new, increasingly expensive and complicated tests appearing almost daily, Laboratory Medicine, Third Edition is required reading for medical students, clinical laboratory scientists, and healthcare professionals who want to keep abreast of the latest testing procedures and maximize accuracy and patient safety. Features: •48 clinical laboratory methods presented in easy-to-understand illustrations that include information on the expense and complexity of the assays •More than 200 tables and full-color algorithms that encapsulate important information and facilitate understanding •Full-color blood-smear micrographs that demonstrate common abnormal morphologies of red blood cells •Valuable learning aids in each chapter, including learning objectives, chapter outlines, and a general introduction -- and new to this edition: chapter-ending self-assessment Q&A •Logical systems-based organization that complements most textbooks •Extensive table of Clinical Laboratory Reference Values that show the conversions between U.S. and SI units for each value

Natural History of the Major Histocompatibility Complex

Natural History of the Major Histocompatibility Complex
Author: Jan Klein
Publisher: Wiley-Interscience
Total Pages: 820
Release: 1986
Genre: Medical
ISBN:

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This work is a natural history of the major histocompatibility complex written for anyone who is working on the MHC but wants to step back and review the complex in its entirety; for anyone who wants to be introduced to the MHC; or for anyone who is just curious about this much talked-about chromosomal region. By natural history is meant an all encompassing treatment of the MHC, both human and mouse, in its entire range and its details - but presented in a way that anybody can understand without consulting a variety of other sources. Most of the details are summarized in the form of tables whereas the text concentrates on generalizations and discussions. Thus, the book will be of interest to immunologists and geneticists seeking an overview of the subject and to graduate students in these disciplines. It will also be of value to technicians working in HLA-typing laboratories.

Modulation of MHC Antigen Expression and Disease

Modulation of MHC Antigen Expression and Disease
Author: G. Eric Blair
Publisher: Cambridge University Press
Total Pages: 462
Release: 1995-11-09
Genre: Medical
ISBN: 9780521495783

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The major histocompatibility complex (MHC) genes are involved in the immune system's response to tumor and infected cells and in generating an immune response. This book brings together basic aspects of the regulation of MHC antigens with important clinical applications (in viral infection, viral oncology, cancer biology and autoimmunity). There is a strong emphasis on situations where MHC expression is modulated (either stimulated or repressed). The book's major themes are: the mechanisms of MHC expression--explored at several levels including the transcription and translation of MHC genes and the insertion of MHC protein molecules into plasma membranes; the effect of cytokines on MHC expression--both in the etiology of certain diseases and in possible immunotherapeutic approaches to disease; and the use of gene therapy to modify MHC expression in cancer cells, and thereby cause tumor rejection. This book will be valuable to researchers and clinicians in molecular biology, immunology, oncology, and virology.