One in five prisoners in the United States has had COVID-19. Incarcerated people are infected four times more than the general population [Schwartzapfel et al., 2020]. These numbers alone prove the dire need for research focused on incarcerated people who have been impacted by the COVID-19 pandemic. This thesis investigates the action or inaction taken by various states across the United States over the course of March 2020 to February 2021 in response to COVID-19 in the prison setting. The procedure consisted of analyzing the basic reproductive number, R0, of COVID-19 infections within numerous prison systems across the country and comparing these values to that of the general state population. R0 is defined as the average number of infections produced by a contagious human in a population where there is no immunity. Aside from the data analysis conducted, research was carried out regarding each states policy implementation throughout 2020 and early 2021. These analyses allowed for a comprehensive examination of the reactive and preventative approaches that each state took to mitigate the spread of COVID-19 in their correctional facilities. Out of the 6 states analyzed (California, Texas, Michigan, Oregon, Ohio, and Arkansas), the state with the highest prison infection rate was Ohio with an R0 of 2.484. On the contrary, the state with the lowest infection rate was Oregon with an R0 of 1.285. Both states differed greatly in their approach to managing the spread of COVID-19 and, thus, had greatly different results. The goal of this thesis is to provide stakeholders in the U.S. prison system with the proper tools and knowledge to better respond to the spread of infectious diseases in the future. This includes better testing, social distancing practices and sanitary measures, as well as de-incarceration efforts, all of which can lead to a decrease in the overall infection rate present in correctional facilities. Effective policies against the spread of COVID-19 ultimately translate into a decrease in total loss in life of incarcerated individuals and prison staff--a heavy burden that highlights the importance of successful infectious disease mitigation policies. As we look ahead into 2021, widespread access to the vaccine for incarcerated individuals will be a determining factor in minimizing the spread of the virus within the correctional setting. Due to each state varying in their vaccine distribution process, the virus will continue spreading in U.S. prisons and will continue to devastate an already marginalized community. If the virus is to be controlled within the prison setting, widespread vaccine distribution for incarcerated populations is a requirement. It is also paramount that each state releases transparent and comprehensive data regarding the testing and protective measures enacted throughout their prison systems. Without adequate reports concerning the status of life inside these prisons, research is hindered, making systemic change related to risk-mitigation strategies for infectious diseases nearly impossible.