The History of Cyclodextrins

The History of Cyclodextrins
Author: Grégorio Crini
Publisher: Springer Nature
Total Pages: 409
Release: 2020-09-29
Genre: Science
ISBN: 3030493083

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This book presents the historical development of Cyclodextrins by scientists who have made outstanding contribution to the field. Cyclodextrins are safe, cage-like molecules that have found major applications in many industrial sectors such as medicine, food, agriculture, environment and chemistry.

Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine

Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine
Author: Erem Bilensoy
Publisher: John Wiley & Sons
Total Pages: 626
Release: 2011-04-27
Genre: Science
ISBN: 0470934611

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Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine covers a wide range of knowledge on cyclodextrins, from an overview of molecular and supramolecular aspects of cyclodextrin physicochemistry, to the latest outcomes in cyclodextrin use and future possibilities in the employment of these systems. This book focuses on the derivatives and physicochemical and biological properties of cyclodextrins, and considers drug delivery through topical, mucosal, and oral via cyclodextrin complexes.

Functionality of Cyclodextrins in Encapsulation for Food Applications

Functionality of Cyclodextrins in Encapsulation for Food Applications
Author: Thao M. Ho
Publisher: Springer Nature
Total Pages: 343
Release: 2021-10-06
Genre: Technology & Engineering
ISBN: 3030800563

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Cyclodextrins (CD) are cyclic oligosaccharides containing 6, 7 or 8 glucose units (α, β or γ-CD, respectively) in a truncated molecular shape. Their cyclic molecular structure contains a hydrophilic surface and a hydrophobic cavity at the center that can interact (host) with external hydrophobic compounds (guest molecules). Cyclodextrins have been categorized as Generally Recognized As Safe (GRAS) in the USA, “natural products” in Japan, and as “novel food” in Australia, New Zealand and EU countries. They are therefore widely used in food production to encapsulate hydrophobic compounds, including solid, liquid and gas molecules, in order to solubilize, stabilize or control the release rate of these components. To date, there has been no comprehensive review of the very large number of studies performed on encapsulation using cyclodextrin powders for food applications in recent years. This text fills that gap for academics in the encapsulation field and for industry professionals who want to gain a solid understanding of encapsulation functionality of cyclodextrin powders. The book consists of 16 chapters in which chapter 1 introduces cyclodextrin properties and its applications in food processing, and chapters 2-16 explore applications of cyclodextrin in encapsulation for many guest compounds. These compounds include gases, flavors, colors, pigments, polyphenols (plant bioactive compounds), essential oils, lipids (cholesterol and polyunsaturated fatty acids), vitamins, fruit ripening controlling compounds, and antifungal and antimicrobial compounds. These chapters also discuss functionalities of cyclodextrin in packaging, masking off-flavor and off-taste, and as dietary fiber. Covering a broad range of cyclodextrin applications and suitable for both newcomers to encapsulation technology and those with experience, Functionality of Cyclodextrins in Encapsulation for Food Applications is a unique and essential reference on this increasingly important topic.

Cyclodextrin Chemistry

Cyclodextrin Chemistry
Author: M. L. Bender
Publisher: Springer Science & Business Media
Total Pages: 107
Release: 2012-12-06
Genre: Science
ISBN: 3642668429

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Chemistry was at one time completely described in terms of collision theo ry, in which one molecule collided with another, sometimes producing reac tion. Then came the realization that enzymes which are highly efficient ca talysts, work by way of prior complexation, often stereospecific, which is then followed by chemical reaction. Thus, systems that exhibit "host-guest" relationships, i.e., that show complexing are being looked at an ever in creasing frequency. The cyclodextrins are the first and probably the most important example of compounds that exhibits complex formation. This is a book about the cyclodextrins. There are of course other compounds that exhibit "host-guest" relationships and thus bind other organic molecules, but so far they have not achieved the importance of the cyclodextrins. By their name it is obvious that cyclodextrins are cyclic compounds. The complexes that they form are therefore cyclic inclusion complexes. Because the complexes are cyclic in nature, complexation can be very strong, as op posed to 1t-complex, electrostatic, or apolar complexes in which complex formation is two-dimensional rather than three-dimensional. Cyclodextrins turn out to be excellent models of enzymes. This is proba bly not fortuitous because they were first sought since it was discovered that the principal binding in the enzyme chymotrypsin was a cyclic inclusion complex. Cyclodextrins can do more than form cyclic inclusion complexes, they can catalyze as well. But catalysis always occurs after complex formation.

Cyclodextrins in Pharmacy

Cyclodextrins in Pharmacy
Author: Karl-Heinz Frömming
Publisher: Springer Science & Business Media
Total Pages: 248
Release: 1993-11-30
Genre: Medical
ISBN: 9780792321392

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Nearly three thousand papers and patents are dedicated to the actual or potential uses of cyclodextrins in pharmacy and pharmaceutical formulations. This is the first book written for pharmacists and pharmaceutical technologists which not only critically summarizes the enormous amount of literature available, but which can be used as a handbook when looking for solutions to practical problems. The fundamentals -- chemistry of cyclodextrins and their derivatives -- their physical and chemical properties are condensed to the most relevant items in Chapters 1 and 2. Chapter 3 deals with the adsorption, metabolism and toxicological properties of cyclodextrins. Chapter 4 explains the formulation, structure, composition and advantageous effects of the cyclodextrin inclusion complexes. Chapter 5 describes the methods for preparation and characterization of drug/cyclodextrin complexes. Chapters 6 and 7 are dedicated to the pharmacokinetics, biopharmaceutical and technological aspects of drug/CD complexes. Chapter 8 treats the application and effects of cyclodextrins in various drug formulations. The Appendix comprises a collection of recipes for any type of drug formulation. This book is aimed at those who use cyclodextrins in drug formulations, to improve the properties of existing drug formulations, or who want to prepare quite new formulations.

Cyclodextrins

Cyclodextrins
Author: Sahar Amiri
Publisher: John Wiley & Sons
Total Pages: 320
Release: 2017-08-30
Genre: Science
ISBN: 1119247543

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The comprehensive resource for understanding the structure, properties, and applications of cyclodextrins Cyclodextrins: Properties and Industrial Applications is a comprehensive resource that includes information on cyclodextrins (CDs) structure, their properties, formation of inclusion complex with various compounds as well as their applications. The authors Sahar Amiri and Sanam Amiri, noted experts in the field of cyclodextrins, cover both the basic and applied science in chemistry, biology, and physics of CDs and offers scientists and engineers an understand of cyclodextrins. Cyclodextrins are a family of cyclic oligosaccharides consisting of (α-1,4)-linked α-D-glucopyranose units. The formation of inclusion complex between CDs as host and guest molecules is based on non-covalent interaction such as hydrogen bonding or van der waals interactions and lead to the formation of supramolecular structures. These supramolecular structures can be used as macroinitiator for initiating various type of reactions. CDs are widely used in many industrial products such as pharmacy, food and flavours, chemistry, chromatography, catalysis, biotechnology, agriculture, cosmetics, hygiene, medicine, textiles, drug delivery, packing, separation processes, environment protection, fermentation, and catalysis. This important resource: Offers a basic understanding of cyclodextrins for researchers and engineers Includes information of the basic structure of cyclodextrins and their properties Reviews how cyclodextrins can be applied in a variety of fields including medicine, chemistry, textiles, packing, and many others Shows how encapsulate corrosion inhibitors became active in corrosive electrolytes to ensure delivery of the inhibitors to corrosion sites and long-term corrosion protection Cyclodextrins offers research scientists and engineers a wealth of information about CDs with particular focus on how cyclodextrins are applied in various ways including in drug delivery, the food industry, and many other areas.

Cyclodextrin Chemistry

Cyclodextrin Chemistry
Author: Zheng-Yu Jin
Publisher: World Scientific
Total Pages: 290
Release: 2013
Genre: Science
ISBN: 9814436801

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Cyclodextrin Chemistry covers the preparation of cyclodextrins and cyclodextrin derivatives (CDs), and their applications in industrial and non-industrial areas. An overall theme in the book is the screening of cyclodextrin glycosyltransferase (CGTase), the preparation of sugar-branched cyclodextrins and CDs, and the use of CDs for reconstructing various supermolecule systems. The specific content also includes preparation methods, spectroscopy techniques for CDs analysis, and potential applications in food packaging, nutrient fortification, medicine, cosmetics, textiles, chemicals, feed, agriculture, and environment. It summarizes the research merit of CDs in the past twenty years and also emphasizes hot topics and important areas of cyclodextrin chemistry in the future. Contents: Introduction (Jun-Rong Huang, Hai-Ning Zhuang and Zheng-Yu Jin); Enzymes in Preparing Cyclodextrins (Sheng-Jun Wu, Xiu-Ting Hu, Jin-Moon Kim and Jing Chen); Preparation and Analysis of Cyclodextrin (An-Wei Cheng, Jin-Peng Wang and Zheng-Yu Jin); Preparation of Branched-Cyclodextrins (Xing Zhou, Yao-Qi Tian and Zheng-Yu Jin); Preparation and Analysis of Cyclodextrin Derivatives (Chao Yuan, Yu-Xiang Bai and Zheng-Yu Jin); Basic Application of Cyclodextrins in Supermolecule Chemistry (Tao Feng, Ai-Quan Jiao and Zheng-Yu Jin); Use of Cyclodextrins in Food, Pharmaceutical and Cosmetic Industries (Yao-Qi Tian, Xing Zhou and Zheng-Yu Jin); Application of Cyclodextrins in Non-industrial Areas (Xue-Hong Li and Zheng-Yu Jin). Readership: Researchers and technicians in food, pharmaceutical, cosmetic and chemical industries, as well as in non-industry areas such as agriculture and environmental engineering, supermolecule and analytical chemistry.

Proceedings of the Fourth International Symposium on Cyclodextrins

Proceedings of the Fourth International Symposium on Cyclodextrins
Author: J. Szejtli
Publisher: Springer Science & Business Media
Total Pages: 527
Release: 2012-12-06
Genre: Medical
ISBN: 9400926375

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The rapidly growing number of papers and patents on Cyclodextrins and their potential or actual industrial uses raised the idea to organize a Symposium on Cyclodextrins. This Symposium - held in September 1981 in Budapest, with more than 200 participants from 17 countries - proved to be very succesfull in every respect, therefore it has been accepted unanimously to organize the lInd CD-Symposium in 1984, in Tokyo. (The Budapest-Symposium got posteriorly the "First" adjective). The IInd Symposium was held together with the III. Int. Symposium on Chlatrate Compounds and Molecular Inclusion Phenomena. The IIIrd CD-Symposium also was held as a Joint Symposium, with the IVth. Chlatrate Symposium in Lancaster, U. K. ,1986. The limited time however showed, that such a broad field - from calixarenes to zeolites - can not be managed efficiently. Therefore the International Organizing Committee voted for separation of two Symposia in the future. The IVth Int. CD-Symposium was held in the Munich, in April 1988, and the Vth Chlatrate Symposium (called already Vth Int. Symposium on Inclusion Phenomena and Molecular Recognition) was held in Alabama, Sept. 1988. In Munich 220 participants from 21 countries attended 32 verbal lectures and 54 posters. This volume contains the submitted 71 manuscripts of the IVth Cyclodextrin Symposium.

Proceedings of the First International Symposium on Cyclodextrins

Proceedings of the First International Symposium on Cyclodextrins
Author: J. Szejtli
Publisher: Springer Science & Business Media
Total Pages: 522
Release: 2013-11-11
Genre: Science
ISBN: 9400978553

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Cyclodextrins are galnlng industrial interest owing to their particu lar structure. These cyclic amyloses are commonly composed of 6, 7 or 8 (named a-, 8-, y-CD) glucose units. They undergo complexation with quite a large number of substances by molecular inclusion. Their potential for in dustrial application is substantiated by their ability to protect fragile substances from oxygen and UV, to delay the evolution of volatiles and to aid the ancillary processing of dangerous or volatile substances in powder ed form. Though a-, 8- and y-CD exhibit different inclusion specificity, 8-CD has found more attention than the others. This is due to the fact that most of the cyclodextrin producing enzymes known produce predominantly 8-CD. Fur thermore 8-CD is by far the least soluble form, leading to a relatively sim ple production and purification. Consequently 8-CD is already in production on an industrial scale [~] while a- and 8-CD are still more or less re garded as specialities. A further CD-producing enzyme has been found in the medium of K. pneu moniae [l], Since this CGT appeared to produce predominantly a-CD [~], it has been chosen to develop a process for the production of a-CD. MATERIALS AND METHODS Analysis of cyclodextrins: HPLC on Lichrosorb-NH . 10 ~m, with acetonitrile 2 water 65/35 per volume. Test for CGT activity: as described by Landert elsewhere in this Volume. Starch: potato starch as obtained from Blattmann, Wadenswil, Switzerland.

Cyclodextrin

Cyclodextrin
Author: Poonam Arora
Publisher: BoD – Books on Demand
Total Pages: 334
Release: 2018-04-18
Genre: Science
ISBN: 1789230683

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The book is devoted to the highly versatile and potential ingredient Cyclodextrin, a family of cyclic oligosaccharides composed of ?-(1,4)-linked glucopyranose subunits. Its molecular complexation phenomena and negligible cytotoxic effects attribute toward its application such as in pharmaceuticals, cosmetics, food, agriculture, textile, separation process, analytical methods, catalysis, environment protection, and diagnostics. Efforts have also been made to concentrate on recent research outcomes along with future prospects of cyclodextrins to attract the interest of scientists from the industry and academia. The contributions of the authors are greatly acknowledged, without which this compilation would not have been possible.