The Effects of Non-invasive Brain Stimulation on Autonomic Regulation

The Effects of Non-invasive Brain Stimulation on Autonomic Regulation
Author: Rosemary Jose Chakiath
Publisher:
Total Pages: 302
Release: 2011
Genre:
ISBN:

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The autonomic nervous system is an important physiological system in the context of health. Heart rate variability is a non-invasive measure of autonomic function. Empirical evidence indicates that reduced heart rate variability may mediate the relationship between psychological states and pathological conditions. This relationship may be indicative of topdown influences on autonomic regulation. Non-invasive brain stimulation offers potential tools to explore top-down pathways that are involved in autonomic regulation. The main aim of this study was to investigate whether transcranial direct current stimulation (tDCS) over the ventral medial pre frontal cortex (vMPFC) could modulate autonomic regulation during psychological stress (Situational HRV) as well as at rest (Tonic HRV) after receiving tDCS. Sixteen participants received either anodal, cathodal or sham tDCS across three, two hour sessions that were counterbalanced across participants. In each session, participants were also asked to complete a mental arithmetic task prior to and after receiving tDCS. Participants also completed questionnaires that assessed their level of fitness, health behaviours and state anxiety. The results showed that there were no after-effects of tDCS on HRV during the cognitive stressor task, despite participants experiencing an increase in heart rate in response to task, prior to receiving the stimulation. Unexpectedly, while HRV returned back to baseline after receiving tDCS, participants showed an increase in HRV during cathodal stimulation over the vMPFC. This suggests that the effects of tDCS on autonomic regulation while not long lasting may occur during the stimulation period itself, thus providing evidence to support the notion of top-down regulation. The findings from this study provide interesting opportunities for future investigations in health psychology in relation to mind-body medicine.

Innovative Technologies and Clinical Applications for Invasive and Non-Invasive Neuromodulation: From the Workbench to the Bedside

Innovative Technologies and Clinical Applications for Invasive and Non-Invasive Neuromodulation: From the Workbench to the Bedside
Author: Matteo Bologna
Publisher: Frontiers Media SA
Total Pages: 149
Release: 2020-02-13
Genre:
ISBN: 2889634698

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The possibility of harvesting the power of electric and magnetic impulses in the human body, commonly referred to as “neuromodulation,” is one of the most recent and promising developments of the modern science. Since the late ´60s, multiple invasive and non-invasive technologies have been developed and tested in experimental and clinical settings with the final aim of modulating the function of the central and peripheral nervous system. Clinical applications include, but are not limited to, common neurological disorders such as Parkinson’s disease and other movement disorders. The bulk of evidence supporting the clinical efficacy of various invasive and non-invasive approaches for neuromodulation has progressively led scientific societies, patients’ associations, and regulatory entities to acknowledge the critical role played by neuromodulation in the therapeutic algorithms of a wide range of neurological disorders. As a result, new technologies have been recently introduced into the market or are currently under validation. Their potential implementation into innovative protocols for neuromodulation demands a critical revision of what are the unmet needs for neuromodulation in movement disorders.

The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders

The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders
Author: Lindsay M. Oberman
Publisher: Frontiers Media SA
Total Pages: 70
Release: 2015-12-03
Genre: Neurosciences. Biological psychiatry. Neuropsychiatry
ISBN: 2889196992

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Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be applied in single pulses to depolarize a small population of neurons in a targeted brain region. This protocol can be used, for example, to map cortical motor outputs, study central motor conduction time, or evaluate the cortical silent period (a measure of intracortical inhibition) all of which are relevant to neurodevelopment. TMS can also be applied in pairs of pulses (paired pulse stimulation, ppTMS) where two pulses are presented in rapid succession to study intracortical inhibition and facilitation. Trains of repeated TMS (rTMS) pulses can be applied at various stimulation frequencies and patterns to modulate local cortical excitability beyond the duration of the stimulation itself. Depending on the parameters of stimulation the excitability can be either facilitated or suppressed. TCS (including Transcranial Direct Current Stimulation (tDCS), alternating current (tACS), and random noise current stimulation (tRNS) also have the potential to modulate cortical excitability and have also been used to study and modulate cortical activity in healthy and patient populations. The after-effects of rTMS and TCS are thought to be related to changes in efficacy (in either the positive or negative direction) of synaptic connections of the neurons being stimulated, thus these techniques have been used to study and modulate cortical plasticity mechanisms in a number of populations. Recently, researchers have begun to apply these techniques to the study of neurodevelopmental mechanisms as well as the pathophysiology and development of novel treatments for neurodevelopmental disorders. Though there is much promise, caution is warranted given the vulnerability of pediatric and clinical populations and the potential that these techniques have to modify circuit development in a cortex that is in a very dynamic state. This Research Topic hopes to provide an opportunity to share ideas across areas (human and animal researchers, clinicians and basic scientists). We are particularly interested in papers that address issues of choosing a protocol (intensity, frequency, location, coil geometry etc.), populations where noninvasive brain stimulation may have direct impact on diagnostics and treatment, as well as the safety and ethics of applying these techniques in pediatric populations. As many may not be aware of the potential and limitations of noninvasive brain stimulation and its use for research and treatment in this area, this Research Topic promises to have broad appeal. Submissions for all Frontiers article types are encouraged.

Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences

Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences
Author: Bernardo Dell'Osso
Publisher: Springer Nature
Total Pages: 365
Release: 2020-07-31
Genre: Medical
ISBN: 3030433560

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This book presents the state of the art regarding the use of non-invasive brain stimulation (TMS and tDCS) in the research and treatment of neuropsychiatric disorders. The contributions, all of which were prepared by internationally recognized experts in the field, are divided into two main sections (for TMS and tDCS, respectively) across diagnoses, following an introductory section on the mechanisms of action and neurophysiological background. Neuropsychological perspectives and approaches are provided as well. The book is ultimately intended to offer a unique, integrated approach to the use of non-invasive brain stimulation across the clinical neurosciences, providing a comprehensive and updated perspective that will benefit psychiatrists, neurologists, clinical psychologists and neurophysiologists alike.

Brain and Human Body Modeling

Brain and Human Body Modeling
Author: Sergey Makarov
Publisher: Springer Nature
Total Pages: 398
Release: 2019-08-27
Genre: Technology & Engineering
ISBN: 3030212939

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This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner. Describes construction and application of computational human models including anatomically detailed and subject specific models; Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations; Includes a survey of modern applications for which computational human models are critical; Describes cellular-level interactions between the human body and electromagnetic fields.

Surgery for Parkinson's Disease

Surgery for Parkinson's Disease
Author: Robert R. Goodman
Publisher: Springer
Total Pages: 0
Release: 2019-01-16
Genre: Medical
ISBN: 9783319236926

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Deep brain stimulation for the treatment of patients with Parkinson’s disease was introduced in the 1990s. Initially performed only at academic centers, over the past decade it has become a widespread surgical procedure. A variety of surgical techniques are employed and innovations are introduced frequently. This book is an ideal source of information for the many practicing neurosurgeons who did not learn this surgery during their training but would now like to add it to their practice, as well as an excellent update on exciting new developments in surgery for Parkinson’s disease. This book is designed to provide practicing neurosurgeons with current knowledge on the practical aspects of surgical treatment of patients with Parkinson’s disease. It explains how to identify surgical candidates and determine the optimal surgery, describes the various surgical techniques that are currently employed, and offers insights into how to optimize deep brain stimulation therapy after implantation. The keys to avoidance of surgical complications are carefully elucidated. In addition, an overview is provided of potential advances on the near-term horizon, including closed-loop deep brain stimulation, gene therapy, and optogenetics. All topics are covered by experienced Parkinson’s disease surgeons, in a concise and digestable format. The book will be an ideal source of information for the many practicing neurosurgeons who would like to add deep brain stimulation to their practice, as well as an excellent update on new developments in surgery for Parkinson’s disease.

Geriatric Forensic Psychiatry

Geriatric Forensic Psychiatry
Author: Jacob Holzer
Publisher: Oxford University Press
Total Pages: 409
Release: 2017-12-12
Genre: Medical
ISBN: 0199374651

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This textbook, one of the first, provides a comprehensive review of the relationship between psychiatry and legal medicine in the older population. Sections reviewing evaluation, civil and criminal topics, and numerous other areas such as risk management, will help physicians, attorneys, and other professionals in their work with the elderly.