The Challenging Of Antibiotic Resistance In The Development Of New Therapeutics
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| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 102 |
| Release | : 2006-01-03 |
| Genre | : Medical |
| ISBN | : 0309180686 |
Download Treating Infectious Diseases in a Microbial World Book in PDF, Epub and Kindle
Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.
| Author | : Manuela Oliveira |
| Publisher | : |
| Total Pages | : |
| Release | : 2015-01-01 |
| Genre | : |
| ISBN | : 9781681081410 |
Download Frontiers in Antimicrobial Agents Book in PDF, Epub and Kindle
The addition of only two novel classes of antibiotics to fight drug resistant microorganisms in the clinic over the past three decades means that the quest for new molecules that are effective against the threat of drug resistance is now a significant issue in modern medicine. Researchers have begun to experiment on alternative therapies to combat this threat. Novel chemical agents are considered to be drugs of choice for tomorrow's clinical practice owing their low probability to generate resistance. The first volume of Frontiers in Antimicrobial Agents describes innovative alternatives to the classical antimicrobial therapeutics, such as phage therapy, AMPs, probiotics, novel biocides, natural products and immunotherapy. Cutting-edge research is brought to the forefront, shedding light on the developments taking place to meet the challenge of drug resistant microorganisms. The volume also features information on antimicrobial approaches in veterinary medicine. The book is a useful reference for researchers, microbiologists and healthcare professionals interested in updates on antibiotic resistance and alternatives to classical antibiotic therapy
| Author | : Manuela Oliveira |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 279 |
| Release | : 2015-12-03 |
| Genre | : Science |
| ISBN | : 1681081407 |
Download The Challenging of Antibiotic Resistance in the Development of New Therapeutics Book in PDF, Epub and Kindle
The addition of only two novel classes of antibiotics to fight drug resistant microorganisms in the clinic over the past three decades means that the quest for new molecules that are effective against the threat of drug resistance is now a significant issue in modern medicine. Researchers have begun to experiment on alternative therapies to combat this threat. Novel chemical agents are considered to be drugs of choice for tomorrow's clinical practice owing to their low probability to generate resistance. The first volume of Frontiers in Antimicrobial Agents describes innovative alternatives to the classical antimicrobial therapeutics, such as phage therapy, AMPs, probiotics, novel biocides, natural products and immunotherapy. Cutting-edge research is brought to the forefront, shedding light on the developments taking place to meet the challenge of drug resistant microorganisms. The volume also features information on antimicrobial approaches in veterinary medicine. The book is a useful reference for researchers, microbiologists and healthcare professionals interested in updates on antibiotic resistance and alternatives to classical antibiotic therapy.
| Author | : National Research Council |
| Publisher | : National Academies Press |
| Total Pages | : 82 |
| Release | : 2014-01-27 |
| Genre | : Science |
| ISBN | : 0309298172 |
Download Technological Challenges in Antibiotic Discovery and Development Book in PDF, Epub and Kindle
Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic discovery and examine the technology available to facilitate development. Through formal presentations and panel discussions, participants from academia, industry, federal research agencies discussed the technical challenges present and the incentives and disincentives industry faces in antibiotic development, and identified novel approaches to antibiotic discovery. Antibiotic resistance is a serious and growing problem in modern medicine and it is emerging as a pre-eminent public health threat. Each year in the United States alone, at least two million acquire serious infections with bacteria that are resistant to one or more antibiotics, and at least 23,000 people die annually as a direct result of these antibiotic-resistant infections. In addition to the toll on human life, antibiotic-resistant infections add considerable and avoidable costs to the already overburdened U.S. health care system. This report explores the challenges in overcoming antibiotic resistance, screening for new antibiotics, and delivering them to the sites of infection in the body. The report also discusses a path forward to develop the next generation of potent antimicrobial compounds capable of once again tilting the battle against microbial pathogens in favor of humans. Technological Challenges in Antibiotic Discovery and Development gives a broad view of the landscape of antibiotic development and the technological challenges and barriers to be overcome.
| Author | : José-Luis Capelo-Martínez |
| Publisher | : John Wiley & Sons |
| Total Pages | : 730 |
| Release | : 2019-09-24 |
| Genre | : Medical |
| ISBN | : 1119282527 |
Download Antibiotic Drug Resistance Book in PDF, Epub and Kindle
This book presents a thorough and authoritative overview of the multifaceted field of antibiotic science – offering guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases. Provides readers with knowledge about the broad field of drug resistance Offers guidance to translate research into tools for prevention, diagnosis, and treatment of infectious diseases Links strategies to analyze microbes to the development of new drugs, socioeconomic impacts to therapeutic strategies, and public policies to antibiotic-resistance-prevention strategies
| Author | : Jun Lin |
| Publisher | : Frontiers Media SA |
| Total Pages | : 226 |
| Release | : 2015-06-01 |
| Genre | : Antibiotics |
| ISBN | : 2889195260 |
Download Mechanisms of antibiotic resistance Book in PDF, Epub and Kindle
Antibiotics represent one of the most successful forms of therapy in medicine. But the efficiency of antibiotics is compromised by the growing number of antibiotic-resistant pathogens. Antibiotic resistance, which is implicated in elevated morbidity and mortality rates as well as in the increased treatment costs, is considered to be one of the major global public health threats (www.who.int/drugresistance/en/) and the magnitude of the problem recently prompted a number of international and national bodies to take actions to protect the public (http://ec.europa.eu/dgs/health_consumer/docs/road-map-amr_en.pdf: http://www.who.int/drugresistance/amr_global_action_plan/en/; http://www.whitehouse.gov/sites/default/files/docs/carb_national_strategy.pdf). Understanding the mechanisms by which bacteria successfully defend themselves against the antibiotic assault represent the main theme of this eBook published as a Research Topic in Frontiers in Microbiology, section of Antimicrobials, Resistance, and Chemotherapy. The articles in the eBook update the reader on various aspects and mechanisms of antibiotic resistance. A better understanding of these mechanisms should facilitate the development of means to potentiate the efficacy and increase the lifespan of antibiotics while minimizing the emergence of antibiotic resistance among pathogens.
| Author | : Prashant Kesharwani |
| Publisher | : Academic Press |
| Total Pages | : 432 |
| Release | : 2020-05-29 |
| Genre | : Business & Economics |
| ISBN | : 0128184809 |
Download Drug Discovery Targeting Drug-Resistant Bacteria Book in PDF, Epub and Kindle
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war
| Author | : Michael Anderson |
| Publisher | : Cambridge University Press |
| Total Pages | : 273 |
| Release | : 2020-04-23 |
| Genre | : Health & Fitness |
| ISBN | : 1108799450 |
Download Challenges to Tackling Antimicrobial Resistance Book in PDF, Epub and Kindle
An accessible overview of the challenges in tackling AMR, and the economic and policy responses of the 'One Health' approach. It will appeal to policy-makers seeking to strengthen national and local polices tackling AMR, as well as students and academics who want an overview of the latest scientific evidence regarding effective AMR policies.
| Author | : William Hall (Author of Superbugs) |
| Publisher | : |
| Total Pages | : |
| Release | : 2018 |
| Genre | : HEALTH & FITNESS |
| ISBN | : 9780674985094 |
Download Superbugs Book in PDF, Epub and Kindle
Antibiotics are powerful drugs that can prevent and treat infections, but they are becoming less effective as a result of drug resistance. Superbugs describes this growing global threat, the systematic failures that have led to it, and solutions that governments, industries, and public health specialists can adopt.--
| Author | : Islam M. Ghazi |
| Publisher | : Bentham Science Publishers |
| Total Pages | : 493 |
| Release | : 2020-11-19 |
| Genre | : Medical |
| ISBN | : 9811461813 |
Download 21st Century Challenges in Antimicrobial Therapy and Stewardship Book in PDF, Epub and Kindle
21st Century Challenges in Antimicrobial Therapy and Stewardship addresses selected topics that are of importance in the practice of infectious disease management. The text starts by illustrating the global landscape of antimicrobial drug resistance, which influences antimicrobial use and therapeutic decisions in the clinic. The contributors explain the reasons for the spread of antibiotic resistance, the pharmacology of antibiotics of different classes, innovative drug delivery methods which can improve the efficacy and safety of new drug candidates and achieve targeted drug delivery as well as drug resistance monitoring techniques and issues in the practice of antimicrobial stewardship and infection control. Key Features: - 14 organized chapters on several aspects of antimicrobial therapy and stewardship - Introductory knowledge on global antimicrobial trends - Coverage of molecular basis of antimicrobial resistance in gram positive, gram negative and fungal microbes - Focused coverage on new developments in antimicrobial drug development, drug delivery, formulation and diagnostic tools - Information on unmet needs of patients and clinicians, including the treatment of difficult infections - Comprehensive coverage of issues in antimicrobial stewardship 21st Century Challenges in Antimicrobial Therapy and Stewardship brings to readers – healthcare administrators, educators, pharmacists, clinicians and students, alike – the knowledge of the molecular basis of antimicrobial drug therapy, drug resistance in pathogens and current practices in antimicrobial stewardship programs. This knowledge, in turn, fosters an awareness among healthcare industry participants to collaborate in an interprofessional environment to combat multidrug resistance.
