Test No 422 Combined Repeated Dose Toxicity Study With The Reproduction Developmental Toxicity Screening Test
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Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 14 |
Release | : 1996-03-22 |
Genre | : |
ISBN | : 9264070982 |
Download Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test Book in PDF, Epub and Kindle
The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks; females should be dosed throughout the study (approximately 54 days). Normally, matings “one male to one ...
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Download Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test Book in PDF, Epub and Kindle
Author | : |
Publisher | : |
Total Pages | : 19 |
Release | : 2015 |
Genre | : |
ISBN | : |
Download Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test Book in PDF, Epub and Kindle
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups and thyroid examination. The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 63 days. Matings "one male to one female" should normally be used in this study. This Test Guideline is designed for use with the rat. It is recommended that each group be started with at least 10 animals of each sex. Generally, at least three test groups and a control group should be used. Dose levels may be based on information from acute toxicity tests or on results from repeated dose studies. The test substance is administered orally and daily. The results of this study include clinical observations, body weight and food/water consumption, oestrous cycle monitoring, offspring parameters observation/measurement, thyroid hormone measurement, as well as gross necropsy and histopathology. The findings of this toxicity study should be evaluated in terms of the observed effects, necropsy and microscopic findings. Because of the short period of treatment of the male, the histopathology of the testis and epididymus should be considered along with the fertility data, when assessing male reproductive effects.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 1996 |
Genre | : |
ISBN | : |
Download OECD Guidelines for the Testing of Chemicals Book in PDF, Epub and Kindle
Author | : |
Publisher | : |
Total Pages | : 17 |
Release | : 2000 |
Genre | : Acute exposure |
ISBN | : |
Download OPPTS 870.3650 Combined Repeated Dose Toxicity Study with the Reproduction/developmental Toxicity Screening Test Book in PDF, Epub and Kindle
Author | : |
Publisher | : |
Total Pages | : 380 |
Release | : 1994 |
Genre | : Effluent quality |
ISBN | : |
Download Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms Book in PDF, Epub and Kindle
Author | : |
Publisher | : DIANE Publishing |
Total Pages | : 275 |
Release | : 2002 |
Genre | : Water quality biological assessment |
ISBN | : 1428905375 |
Download Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms Book in PDF, Epub and Kindle
Author | : National Research Council |
Publisher | : National Academies Press |
Total Pages | : 270 |
Release | : 2006-04-07 |
Genre | : Nature |
ISBN | : 0309164869 |
Download Toxicity Testing for Assessment of Environmental Agents Book in PDF, Epub and Kindle
Toxicity testing in laboratory animals provides much of the information used by the Environmental Protection Agency (EPA) to assess the hazards and risks associated with exposure to environmental agents that might harm public health or the environment. The data are used to establish maximum acceptable concentrations of environmental agents in drinking water, set permissible limits of exposure of workers, define labeling requirements, establish tolerances for pesticides residues on food, and set other kinds of limits on the basis of risk assessment. Because the number of regulations that require toxicity testing is growing, EPA called for a comprehensive review of established and emerging toxicity-testing methods and strategies. This interim report reviews current toxicity-testing methods and strategies and near-term improvements in toxicity-testing approaches proposed by EPA and others. It identifies several recurring themes and questions in the various reports reviewed. The final report will present a long-range vision and strategic plan to advance the practices of toxicity testing and human health assessment of environmental contaminants.
Author | : Andrew G. Mtewa |
Publisher | : John Wiley & Sons |
Total Pages | : 444 |
Release | : 2020-12-22 |
Genre | : Science |
ISBN | : 1119650232 |
Download Poisonous Plants and Phytochemicals in Drug Discovery Book in PDF, Epub and Kindle
Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career
Author | : OECD |
Publisher | : OECD Publishing |
Total Pages | : 10 |
Release | : 1995-07-27 |
Genre | : |
ISBN | : 9264070966 |
Download Test No. 421: Reproduction/Developmental Toxicity Screening Test Book in PDF, Epub and Kindle
The test substance is administered in graduated doses to several groups of males and females. Males should be dosed for a minimum of four weeks. Females should be dosed throughout the study, so approximately 54 days. This Test Guideline is designed ...