Systematic

Systematic
Author: James R. Valcourt
Publisher: Bloomsbury Publishing USA
Total Pages: 289
Release: 2017-02-07
Genre: Science
ISBN: 1632860317
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A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.

Assembling the Pieces of a Systematic Review

Assembling the Pieces of a Systematic Review
Author: Margaret J. Foster
Publisher: Rowman & Littlefield
Total Pages: 243
Release: 2017-03-03
Genre: Language Arts & Disciplines
ISBN: 1442277025
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Here is a complete guide for librarians seeking to launch or refine their systematic review services. Conducting searches for systematic reviews goes beyond expert searching and requires an understanding of the entire process of the systematic review. Just as expert searching is not fully mastered by the end of a library degree, mastering the systematic review process takes a great deal of time and practice. Attending workshops and webinars can introduce the topic, but application of the knowledge through practice is required. Running a systematic review service is complicated and requires constant updating and evaluation with new standards, more efficient methods, and improved reporting guidelines. After a brief introduction to systematic reviews, the book guides librarians in defining and marketing their services, covering topics such as when it is appropriate to ask for co-authorship and how to reach out to stakeholders. Next, it addresses developing documentation and conducting the reference interview. Standards specific to systematic reviews, including PRISMA, Institute of Medicine, and Cochrane Collaboration, are discussed. Search strategy techniques, including choosing databases, harvesting search terms, selecting filters, and searching for grey literature are detailed. Data management and critical appraisal are covered in detail. Finally, the best practices for reporting the findings of systematic reviews are highlighted. Experts with experience in both systematic reviews and librarianship, including the editors of the book, contributed to the chapters. Each step (or piece) of the review process (Planning the review, Identifying the studies, Evaluating studies, Collecting and combining data, Explaining the results, and Summarizing the review into a report), are covered with emphasis on information roles. The book is for any librarian interested in conducting reviews or assisting others with reviews. It has several applications: for training librarians new to systematic reviews, for those developing a new systematic review service, for those wanting to establish protocols for a current service, and as a reference for those conducting reviews or running a service. Participating in systematic reviews is a new frontier of librarianship, in which librarians can truly become research partners with our patrons, instead of merely providing access to resources and services.

An Introduction to Systematic Reviews

An Introduction to Systematic Reviews
Author: David Gough
Publisher: SAGE
Total Pages: 382
Release: 2012-03-22
Genre: Literary Criticism
ISBN: 1446289362
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This timely, engaging book provides an overview of the nature, logic, diversity and process of undertaking systematic reviews as part of evidence informed decision making. A focused, accessible and technically up-to-date book, it covers the full breadth of approaches to reviews from statistical meta analysis to meta ethnography. It is ideal for anyone undertaking their own systematic review - providing all the necessary conceptual and technical background needed to make a good start on the process. The content is divided into five clear sections: • Approaches to reviewing • Getting started • Gathering and describing research • Appraising and synthesising data • Making use of reviews/models of research use. Easy to read and logically structured, this book is essential reading for anyone doing systematic reviews. David Gough is Professor of Evidence Informed Policy and Practice and Director of SSRU and its EPPI-Centre and Co-Editor of the journal Evidence & Policy. Sandy Oliver is Professor of Public Policy and Deputy Director of SSRU and its EPPI-Centre. James Thomas is Reader in Social Policy, Assistant Director of SSRU and Associate Direcctor of the EPPI-Centre.

Finding What Works in Health Care

Finding What Works in Health Care
Author: Institute of Medicine
Publisher: National Academies Press
Total Pages: 267
Release: 2011-07-20
Genre: Medical
ISBN: 0309164257
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Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

An Introduction to Systematic Reviews

An Introduction to Systematic Reviews
Author: David Gough
Publisher: SAGE
Total Pages: 353
Release: 2017-03-28
Genre: Social Science
ISBN: 1473968216
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Focused on actively using systematic review as method, this book provides clear, step-by-step advice on the logic and processes of systematic reviewing. Stressing the importance of precision and accuracy, this new edition carefully balances a need for insightful theory with real-world pragmatism; it introduces a wide range of cutting-edge approaches to research synthesis including text mining, living reviews and new ideas in mixed methods reviews such as qualitative comparative analysis. The book also includes: A new chapter on statistical synthesis Coverage of computer-assisted methods and relevant software Expanded sections on data extraction and management A guide to working with many different types of data including longitudinal and panel. Packed with examples from across the social sciences, this book helps students and researchers alike in turning systematic reviews into recommendations for policy and practice.

Systematic Searching

Systematic Searching
Author: Paul Levay
Publisher: Facet Publishing
Total Pages: 352
Release: 2019-01-15
Genre: Language Arts & Disciplines
ISBN: 1783303735
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In resource poor, cost saving times, this book provides practical advice on new methods and technologies involved in systematic searching and explores the role of information professionals in delivering these changes The editors bring together expert international practitioners and researchers to highlight the latest thinking on systematic searching. Beginning by looking at the methods and techniques underlying systematic searching, the book then examines the current challenges and the potential solutions to more effective searching in detail, before considering the role of the information specialist as an expert searcher. Systematic Searching blends theory and practice and takes into account different approaches to information retrieval with a special focus being given to searching for complex topics in a health-related environment. The book does not presume an in-depth prior knowledge or experience of systematic searching and includes case studies, practical examples and ideas for further research and reading. The book is divided into three parts: Methods covers theoretical approaches to evidence synthesis and the implications that these have for the search process, including searching for complex topics and choosing the right sources. Technology examines new technologies for retrieving evidence and how these are leading to new directions in information retrieval and evidence synthesis. People considers the future of the information specialist as an expert searcher and explores how information professionals can develop their skills in searching, communication and collaboration to ensure that information retrieval practice is, and remains, evidence-based. Systematic Searching will be essential reading for library and information service providers and information specialists, particularly those in a health-related environment. It will also be of interest to students of library and information science, systematic reviewers, researchers and practitioners conducting complex searches in settings including social care, education and criminal justice.

Cochrane Handbook for Systematic Reviews of Interventions

Cochrane Handbook for Systematic Reviews of Interventions
Author: Julian P. T. Higgins
Publisher: Wiley
Total Pages: 672
Release: 2008-11-24
Genre: Medical
ISBN: 9780470699515
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Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Principles and Practice of Systematic Reviews and Meta-Analysis

Principles and Practice of Systematic Reviews and Meta-Analysis
Author: Sanjay Patole
Publisher: Springer Nature
Total Pages: 189
Release: 2021-06-26
Genre: Medical
ISBN: 3030719219
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Evidence based medicine is at the core of modern medicine. It involves the integration of individual clinical expertise with the best available clinical evidence from systematic research and patient's values and expectations. Systematic reviews offer a summary of the best available evidence. They are the most reliable and comprehensive statement about what works. Written by clinical academics from Australia, UK, USA, and Switzerland, this contributed volume introduces the readers to the principles and practice of systematic reviews and meta-analysis. It covers the various steps involved in systematic reviews including development of a focused question and the strategy for conducting a comprehensive literature search, identifying studies addressing the underlying question, assessment of heterogeneity and the risk of bias in the included studies, data extraction, and the approach to meta-analysis. Crucial issues such as selecting the model for meta-analysis, generating and interpreting forest plots, assessing the risk of publication bias, cautions in the interpretation of subgroup and sensitivity analyses, rating certainty of the evidence using GRADE guideline, and standardized reporting of meta-analysis (PRISMA) are covered in detail. Every attempt is made to keep the narrative simple and clear. Mathematical formulae are avoided as much as possible. While the focus of this book is on systematic reviews and meta-analyses of randomised controlled trials (RCTs), the gold standard of clinical research, the essentials of systematic reviews of non-RCTs, diagnostic test accuracy studies, animal studies, individual participant data meta-analysis, and network meta-analysis are also covered. Readers from all faculties of medicine will enjoy this comprehensive and reader friendly book to understand the principles and practice of systematic reviews and meta-analysis for guiding their clinical practice and research.

Systematic Reviews in Health Care

Systematic Reviews in Health Care
Author: Matthias Egger
Publisher: John Wiley & Sons
Total Pages: 512
Release: 2008-04-15
Genre: Medical
ISBN: 0470693142
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The second edition of this best-selling book has been thoroughly revised and expanded to reflect the significant changes and advances made in systematic reviewing. New features include discussion on the rationale, meta-analyses of prognostic and diagnostic studies and software, and the use of systematic reviews in practice.

Cochrane Handbook for Systematic Reviews of Interventions

Cochrane Handbook for Systematic Reviews of Interventions
Author: Julian P. T. Higgins
Publisher: John Wiley & Sons
Total Pages: 739
Release: 2019-09-23
Genre: Medical
ISBN: 1119536650
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The revised edition of the Handbook offers the only guide on how to conduct, report and maintain a Cochrane Review The second edition of The Cochrane Handbook for Systematic Reviews of Interventions contains essential guidance for preparing and maintaining Cochrane Reviews of the effects of health interventions. Designed to be an accessible resource, the Handbook will also be of interest to anyone undertaking systematic reviews of interventions outside Cochrane, and many of the principles and methods presented are appropriate for systematic reviews addressing research questions other than effects of interventions. This fully updated edition contains extensive new material on systematic review methods addressing a wide-range of topics including network meta-analysis, equity, complex interventions, narrative synthesis, and automation. Also new to this edition, integrated throughout the Handbook, is the set of standards Cochrane expects its reviews to meet. Written for review authors, editors, trainers and others with an interest in Cochrane Reviews, the second edition of The Cochrane Handbook for Systematic Reviews of Interventions continues to offer an invaluable resource for understanding the role of systematic reviews, critically appraising health research studies and conducting reviews.