PART I Health-Related Quality of Life after burn injury In order to reveal and summarize the current knowledge on HRQL after burns, an extensive systematic literature review was performed. Results of Chapter 2 and Chapter 4 show that HRQL is increasingly studied after burn injury and no consensus consists on what specific HRQL instrument(s) should be used in adults or children after burn injuries. In adults, participation restrictions due to physical functional limitations and emotional distress remained, including limitations of regular daily activities like work. In addition, burn patients seemed to be on average more anxious and/or depressed compared to the general population and a large number of patients continued experiencing pain and/or discomfort in the long term. In children, especially appearance and parental concern remained a problem (Chapter 4). Patients with major burns experienced evidently more problems than patients with mild burns, and patients with psychological problems before or shortly after the injury are frequently seen to maintain problems in the long-term and should therefore be carefully monitored (Chapter 3). In children, the psychological impact is barely studied. Paediatric patients with major burns, facial burns, hand burns, and comorbidity experienced a poorer long-term HRQL and required special attention. PART II Clinimetric studies on outcomes In Chapter 5 measurement properties of instruments that have been used to assess HRQL in burn patients were critically assessed. Results showed that the Burns Specific Health Scale-brief (BSHS-B) and the Brisbane Burn Scar Impact Profile (BBSIP), have somewhat more favourable properties compared to other instruments. To further improve the understanding of HRQL after burn injury, consensus on uniformly validated instrument(s), time assessment points and data presentation is needed.