Sulfonyl Ynamides as Useful Tools for N-Heterocyclic Chemistry

Sulfonyl Ynamides as Useful Tools for N-Heterocyclic Chemistry
Author: Tim Wezeman
Publisher: Logos Verlag Berlin GmbH
Total Pages: 253
Release: 2016-12-31
Genre: Science
ISBN: 383254397X

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Sulfonyl ynamides are highly versatile and synthetically useful reagents. This thesis details the modular synthesis and use of sulfonyl ynamides in order to access N-heterocyclic scaffolds, such as quinolines and pyrazoles. The synthesis of a wide array of sulfonyl ynamides can be realized via copper-catalyzed amidative cross-couplings or by elimination of dichloroenamide precursors. Additionally the use of Sonogashira chemistry to further diversify terminal ynamides and the synthesis of solid-supported ynamides was investigated. Electrophilically-activated amides can be reacted with sulfonyl ynamides in order to access highly functionalized 4-aminoquinolines. The straightforward amide activation procedure with triflic anhydride and 2-chloropyridine was found to tolerate a wide range of substrates, which allowed for the development of a library of 4-aminoquinolines with ease. Moreover, 4-aminopyrazoles can be prepared by reacting terminal sulfonyl ynamides with sydnones under copper catalysis. However, as the copper catalysts were also found to promote the degradation of the ynamides, a copper-free strain-promoted alternative was developed. An in situ prepared 3-azacyclohexyne was found to tolerate a wide array of C-4 substituted sydnones, producing a mixture of both the 3,4- and 4,3-fused pyrazoles in good yields. Additional investigations into heterocyclic methodology led to the development of highly sophisticated, non-symmetrical and axially-chiral dibenzo-1,3-diazepines, -oxazepines and -thiazepines from simple, commercially available anilines. The anilines were coupled to their corresponding reaction partners via a chloromethyl intermediate and the 7-membered ring was subsequently formed using direct arylation.

Progress in Heterocyclic Chemistry

Progress in Heterocyclic Chemistry
Author: Gordon Gribble
Publisher: Elsevier
Total Pages: 497
Release: 2009-06-16
Genre: Science
ISBN: 0080914950

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This is the 20th annual volume of Progress in Heterocyclic Chemistry, which covers the literature published during 2007. As with previous volumes in the series, Volume 20 will enable the reader to keep abreast of developments in heterocyclic chemistry in an effortless way. * A critical review of the heterocyclic literature published during 2007 * Presents specialized reviews * Chapters all written by leading researchers in their field

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds
Author: Henri Groult
Publisher: Elsevier
Total Pages: 792
Release: 2016-11-04
Genre: Science
ISBN: 0128037903

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Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Team and Individual Games: Comparison of Psycho-Physiological Characteristics of Sportsperson

Team and Individual Games: Comparison of Psycho-Physiological Characteristics of Sportsperson
Author: Dr. Pankaj Gangalal Yadav
Publisher: Ashok Yakkaldevi
Total Pages: 291
Release: 2021-10-21
Genre: Art
ISBN: 1458314588

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As the son of an international swimmer, Dr. Pankaj Yadav is proudly following the legacy of his father, Mr. Gangalal Yadav, who represented India at Perth in Australia in a prestigious International swimming competition and retired as a successful District Sports Officer. As a successor of his father's legacy, Dr. Pankaj Yadav bagged two Bronze Medals in Maharashtra State Championship, while studying in college he participated in six All India Inter-University Zonal Competitions of swimming which were held at Kerala, Punjab and West Bengal. Dr. Pankaj is a highly energetic and dedicated Physical Education Teacher with four years of experience. He possesses excellent communication skills as well as strong work ethics, and trying his level best in executing educational lessons into practice and maintaining exemplary physical fitness. Dr. Pankaj has profound knowledge of physical fitness and human anatomy. He is truly committed to keep students pro-active and to promote healthy lifestyle choices through hands-on activities. A highly inspirational individual with excellent experience in teaching, Dr. Pankaj claims time management and motivational skills too. As an effective team leader with esteemed ability to manage and increase productivity within the team, he worked as a successful team manager of Boxing Team of SRTM University, Nanded at Udaypur, Rajasthan.

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
Author: Jie Jack Li
Publisher: John Wiley & Sons
Total Pages: 688
Release: 2013-04-26
Genre: Science
ISBN: 1118354435

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Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the field review more than 100 years of findings, explaining their relevance to contemporary drug discovery practice. Moreover, these authors have provided plenty of practical guidance and tips based on their own academic and industrial laboratory experience, helping readers avoid common pitfalls. Heterocyclic Chemistry in Drug Discovery is ideal for readers who want to fully realize the almost limitless potential to discover new and effective pharmaceuticals among heterocyclic compounds, the largest and most varied family of organic compounds. The book features: Several case studies illustrating the role and application of 3, 4, 5, and 6+ heterocyclic ring systems in drug discovery Step-by-step descriptions of synthetic methods and practical techniques Examination of the physical properties for each heterocycle, including NMR data and quantum calculations Detailed explanations of the complexity and intricacies of reactivity and stability for each class of heterocycles Heterocyclic Chemistry in Drug Discovery is recommended as a textbook for organic and medicinal chemistry courses, particularly those emphasizing heterocyclic chemistry. The text also serves as a guide for medicinal and process chemists in the pharmaceutical industry, offering them new insights and new paths to explore for effective drug discovery.

Catalytic Cascade Reactions

Catalytic Cascade Reactions
Author: Peng-Fei Xu
Publisher: John Wiley & Sons
Total Pages: 440
Release: 2013-11-11
Genre: Science
ISBN: 1118016025

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Demonstrates the advantages of catalytic cascade reactions for synthesizing natural products and pharmaceuticals Riding the wave of green chemistry, catalytic cascade reactions have become one of the most active research areas in organic synthesis. During a cascade reaction, just one reaction solvent, one workup procedure, and one purification step are needed, thus significantly increasing synthetic efficiency. Featuring contributions from an international team of pioneers in the field, Catalytic Cascade Reactions demonstrates the versatility and application of these reactions for synthesizing valuable compounds. The book examines both organocatalysis and transition-metal catalysis reactions, bringing readers up to date with the latest discoveries and activities in all major areas of catalytic cascade reaction research. Catalytic Cascade Reactions begins with three chapters dedicated to organocatalytic cascade reactions, exploring amines, Brønsted acids, and the application of organocatalytic cascade reactions in natural product synthesis and drug discovery. Next, the book covers: Gold-catalyzed cascade reactions Cascade reactions catalyzed by ruthenium, iron, iridium, rhodium, and copper Palladium-catalyzed cascade reactions of alkenes, alkynes, and allenes Application of transition-metal catalyzed cascade reactions in natural product synthesis and drug discovery Engineering mono- and multifunctional nanocatalysts for cascade reactions Multiple-catalyst-promoted cascade reactions All chapters are thoroughly referenced, providing quick access to important original research findings and reviews so that readers can explore individual topics in greater depth. Drawing together and analyzing published findings scattered across the literature, this book provides a single source that encapsulates our current understanding of catalytic cascade processes. Moreover, it sets the stage for the development of new catalytic cascade reactions and their applications.

Click Polymerization

Click Polymerization
Author: Anjun Qin
Publisher: Royal Society of Chemistry
Total Pages: 260
Release: 2018-08-28
Genre: Science
ISBN: 1782627162

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Click Polymerization has been edited by world renowned experts and provides an authoritative guide to this reaction type.

Isocyanide-based Multicomponent Reactions

Isocyanide-based Multicomponent Reactions
Author: Jonathan G. Rudick
Publisher: Frontiers Media SA
Total Pages: 100
Release: 2020-02-20
Genre:
ISBN: 2889634841

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

The Chemistry of Heterocycles

The Chemistry of Heterocycles
Author: Vishnu Ji Ram
Publisher: Elsevier
Total Pages: 500
Release: 2019-06-05
Genre: Science
ISBN: 0081011911

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Heterocycles are ubiquitously present in nature and occupy a unique place in organic chemistry as they are part of the DNA and haemoglobin that make life possible. The Chemistry of Heterocycles covers an introduction to the topic, followed by a chapter on the nomenclature of all classes of isolated, fused and polycyclic heterocycles. The third chapter delineates the highly strained three membered N,O and S containing aromatic and non-aromatic heterocycles with one and more than one similar and dissimilar heteroatom. The four-membered heterocycles are abundantly present in various natural and synthetic products of pharmacological importance. This chapter describes the natural abundance, synthesis, chemical reactivity, structural features and their medicinal importance. This class of compounds are present as sub-structures in penicillin and cytotoxic Taxol. Lastly, a chapter on the natural abundance, synthesis, chemical reactivity and pharmacological importance of 5-membered heterocycles with N,O,S heteroatom is covered. The chemistry of heterocycles with mixed heteroatom such as, N-S, N-O, N-S etc. is also described. Gives in-depth, clear information about various systems of nomenclature along with widely acceptable IUPAC system for naming various classes of heterocycles Provides complete information about natural occurrences, synthesis, chemical reactivity, pharmacological importance of heterocycles and their application in material science Highly relevant for graduate students and researchers, providing updated information about various isolated and fused N,O and,S containing heterocycles

Fluorinated Heterocycles

Fluorinated Heterocycles
Author: American Chemical Society. Meeting
Publisher:
Total Pages: 390
Release: 2009
Genre: Language Arts & Disciplines
ISBN:

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This is the first ACS symposium series book solely devoted to fluorinated heterocyclic compounds. Its contents encompasses all aspects of chemistry and applications of fluoroheterocycles including synthesis, biological activity, computational and medicinal research covering all major classes of heterocycles as well as popular fluorine-containing fragments.