Strontium-incorporated Titanium Implants Promote Bone-implant Osseointegration in Osteoporotic Rabbits
Author | : Lin Guo-Fen |
Publisher | : |
Total Pages | : |
Release | : 2017 |
Genre | : |
ISBN | : |
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Background (500 characters max.)Implant failure may occur in patients with osteoporosis, especially in elderly over 50 years including postmenopausal females1. This osteoporosis leads to insufficient bone-implant contact and can severely deteriorate the primary stability and osseointegration establishment of dental implant. Recently, the positive effects of Strontium (Sr) iron on inhibiting bone resorption and promoting bone formation have been elucidated in numerous studies. Our previous in vitro and vivo studies incorporated Sr iron onto the surface of SLA implant by hydrothermal treatment, and the results demonstrated that Sr-incorporated surfaces has a positive influence on mesenchymal stem cell (MSC) differentiation and enhancing implant osseointegration in healthy animals2.Aim/Hypothesis (300 characters max.)The aim of this study was designed to compare the osseointegration behavior of conventional SLA implants and Sr-SLA implants in ovariectomized rabbits.Materials and Methods (1000 characters max.)Thirty-two New Zealand rabbits, half of which were carried out with bilateral ovariectomy and glucocorticoid administration for six weeks (OVX group), and another 16 rabbits were conducted with SHAM operation as for control group. Bone mineral density of lumbar spines (L3u2013L5), global knee bone and subchondral bone was measured before and after ovariectomy or SHAM operations using dual energy X-ray absorptiometry (Fig.1). After successful osteoporotic-induced model, the SLA and Sr-SLA implants were randomly inserted into the tibia and femur metaphysis of each animal. The rabbits were respectively sacrificed 3 and 6 weeks after dental implant placement. The samples from femur metaphysis in each group at each time point were subjected to removal torque testing, and the remaining samples from tibia metaphysis were conducted for histomorphometric analysis3.Results (1000 characters max.)At the end of the healing period, all implants were osseointegrated and histologically in direct contact with the surrounding bone. The Sr-SLA implants displayed closer contact and much more newly formed bone than the SLA implants (Fig.2). At 3 weeks (Fig.3), the removal torque values (RTV) of the Sr-SLA implants were significantly higher than those of the SLA implants in both OVX (P