Spectroscopic Probes of the Non-heme Iron Active Sites
Author | : Yan Zhang |
Publisher | : |
Total Pages | : 438 |
Release | : 1992 |
Genre | : |
ISBN | : |
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Author | : Yan Zhang |
Publisher | : |
Total Pages | : 438 |
Release | : 1992 |
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ISBN | : |
Author | : Erik Christopher Wasinger |
Publisher | : |
Total Pages | : 572 |
Release | : 2003 |
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Author | : Kelly Elise Loeb |
Publisher | : |
Total Pages | : 600 |
Release | : 1997 |
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Author | : Mark A. Pavlosky |
Publisher | : |
Total Pages | : 368 |
Release | : 1994 |
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Author | : Yeonju Kwak |
Publisher | : |
Total Pages | : |
Release | : 2013 |
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ISBN | : |
Binuclear non-heme iron enzymes catalyze various reactions including H-atom abstraction, desaturation, hydroxylation, and electrophilic aromatic substitution through O2 activation. In addition, they protect cells from oxidative stress and regulate iron levels in the cell. These enzymes utilize two irons and have common structural motif of 2-His / 4-carboxylate. Despite the enzymes' structural similarities, subtle changes at their active sites allow these enzymes to have different reactivities. Understanding the active site structures of these enzymes and the key mechanistic features related to these structures can provide a basis for potential applications: they could be drug inhibition targets to treat cancer, diabetes, and pathogenic diseases; they could work as biocatalysts; and they could carry out bioremediation reactions. In this dissertation, studies that examine three binuclear non-heme iron and Mn/Fe enzyme active sites (class Ic ribonucleotide reductase, ferritin variants, and bacterioferritin) and peroxo-bridged biferric model complexes are described. A combined spectroscopic methodology of nuclear resonance vibrational spectroscopy (NRVS), circular dichroism (CD), magnetic circular dichroism (MCD), and variable temperature, variable field (VTVH) MCD is used to probe geometric and electronic structures of Mn and Fe centers in protein active site and in model complexes.
Author | : Carl A. Brown |
Publisher | : |
Total Pages | : 452 |
Release | : 1994 |
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Author | : Marina Su Yin Chow |
Publisher | : |
Total Pages | : 512 |
Release | : 2008 |
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Author | : James Malcolm McCormick |
Publisher | : |
Total Pages | : 536 |
Release | : 1991 |
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Author | : Jing Zhou |
Publisher | : |
Total Pages | : 398 |
Release | : 2000 |
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Author | : |
Publisher | : Elsevier |
Total Pages | : 348 |
Release | : 2024-09-01 |
Genre | : Science |
ISBN | : 0443313059 |
Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more. Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoid dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more. Provides detailed articles regarding how to study the structures and mechanisms of mononuclear non-heme iron dependent enzymes Guides readers on how to use partner proteins in non-heme iron enzyme catalysis Includes strategies to employ mononuclear non-heme iron enzymes in biocatalytic applications