Recent Trends in Antifungal Agents and Antifungal Therapy

Recent Trends in Antifungal Agents and Antifungal Therapy
Author: Amit Basak
Publisher: Springer
Total Pages: 254
Release: 2016-09-21
Genre: Science
ISBN: 8132227824
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Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural to synthetic sources. It is necessary to discover new classes of antifungals to control the recent emergence of multi-drug resistant fungal infections. This book proposed a details top to bottom outline of antifungal compounds derived naturally or synthetically. The details of their modifications or synthetic analogues have been described, helpful to understand the structure-activity relationship which leads to new compound development in antifungal chemotherapy. Each chapter begins with a comprehensive, top-bottom in-depth discussion of antifungal agents with updated bibliographic references. This compendium will serve as a companion not only for Scientists, Researchers, and Professors, Medical Practitioners but also a valuable reference text for the university students.

Antifungal Therapy

Antifungal Therapy
Author: Mahmoud Ghannoum
Publisher: CRC Press
Total Pages: 484
Release: 2016-04-19
Genre: Medical
ISBN: 0849387868
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A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c

Recent Developments in Anti-Fungal Agents

Recent Developments in Anti-Fungal Agents
Author: Mohd. Shahid
Publisher: LAP Lambert Academic Publishing
Total Pages: 124
Release: 2011-01
Genre:
ISBN: 9783843387132
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Invasive fungal infections (IFIs) demand a tremendous levy in terms of human life and healthcare costs, despite the fact that fungal diseases are still under-diagnosed and under reported. Several factors such as patient characteristics, antifungal prophylaxis and others appear to have contributed to a change in the spectrum of invasive fungal pathogens (i.e. Candida species, Non-Candida species, Aspergillus species and Non-Aspergillus species). Therefore, it is important to recognize and minimize the major risk factors associated with infection, and expanding the antifungal drug research for new antifungal agents to treat life-threatening invasive infections. This book would highlight past and current research on fungal pathogens and antifungal therapies, and also novel targets for antifungal agents for future development in medical practice to prevent invasive fungal infections. The book will describe novel antifungal agents, its targets, and various development phases and potential benefits of combination therapy.

Antifungal Drug Discovery: New Theories and New Therapies

Antifungal Drug Discovery: New Theories and New Therapies
Author: Chaminda Jayampath Seneviratne
Publisher: Frontiers Media SA
Total Pages: 138
Release: 2016-09-13
Genre: Microbiology
ISBN: 2889199509
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Fungal infections such as candidoses can range from superficial mucous membrane infection to life-threatening systemic mycoses. Candida infections are a significant clinical problem globally due to rapid rise in compromised host populations including HIV/AIDS, organ transplant recipients and patients on chemotherapy. In addition, sharp increase in aging populations which are susceptible to fungal infections is expected in next few decades. Antifungal drugs are relatively difficult to develop compared to the antibacterial drugs owing to the eukaryotic nature of the cells. Therefore, only a handful of antifungal agents are currently available to treat the myriad of fungal infections. Moreover, rising antifungal resistance and host-related adverse reactions have limited the antifungal arsenal against fungal pathogens. In this research topic, we tried to update the theoretical aspects pertaining to the antifungal drug discovery i.e. proposed novel mechanisms, new drug targets and pathways. In addition, invited authors explored the new antifungal drugs derived from natural and synthetic sources which are currently under development. Contributors were encouraged to bring new insight into the antifungal drug discovery. We hope the reader may arrive at a general consensus on the possible strategies to combat ever increasing ubiquitous fungal infection in this new century.

Antifungal Agents

Antifungal Agents
Author: Ernst M. Jucker
Publisher: Birkhäuser
Total Pages: 253
Release: 2012-12-06
Genre: Medical
ISBN: 3034879741
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This second volume of PDR SPECIAL TOPICS contains five review articles, covering nearly the entire field of fungal diseases in humans as well as therapeutic approaches. The main emphasis of the book lies in antifungal therapy: the most relevant information on the present state of the art of antifungal chemotherapy for dermatomycoses, subcutaneous and invasive mycoses is summarized, and open questions and unsolved problems are presented. The book is ideal for both the practitioner as well as advanced student.

Antifungal Chemotherapy

Antifungal Chemotherapy
Author: D. C. E. Speller
Publisher: John Wiley & Sons
Total Pages: 472
Release: 1980
Genre: Medical
ISBN:
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Inorganic Chemical Biology

Inorganic Chemical Biology
Author: Gilles Gasser
Publisher: John Wiley & Sons
Total Pages: 437
Release: 2014-06-23
Genre: Science
ISBN: 111851002X
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Understanding, identifying and influencing the biological systems are the primary objectives of chemical biology. From this perspective, metal complexes have always been of great assistance to chemical biologists, for example, in structural identification and purification of essential biomolecules, for visualizing cellular organelles or to inhibit specific enzymes. This inorganic side of chemical biology, which continues to receive considerable attention, is referred to as inorganic chemical biology. Inorganic Chemical Biology: Principles, Techniques and Applications provides a comprehensive overview of the current and emerging role of metal complexes in chemical biology. Throughout all of the chapters there is a strong emphasis on fundamental theoretical chemistry and experiments that have been carried out in living cells or organisms. Outlooks for the future applications of metal complexes in chemical biology are also discussed. Topics covered include: • Metal complexes as tools for structural biology • IMAC, AAS, XRF and MS as detection techniques for metals in chemical biology • Cell and organism imaging and probing DNA using metal and metal carbonyl complexes • Detection of metal ions, anions and small molecules using metal complexes • Photo-release of metal ions in living cells • Metal complexes as enzyme inhibitors and catalysts in living cells Written by a team of international experts, Inorganic Chemical Biology: Principles, Techniques and Applications is a must-have for bioinorganic, bioorganometallic and medicinal chemists as well as chemical biologists working in both academia and industry.

Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier

Vaccines, Immunotherapy and New Antifungal Therapy Against Fungi: Updates in the New Frontier
Author: Carlos P. Taborda
Publisher: Frontiers Media SA
Total Pages: 185
Release: 2017-11-15
Genre:
ISBN: 2889453278
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Invasive fungal diseases have increased many fold over the past 50 years. Current treatment regimens typically require prolonged administration of antifungal medications that can have significant toxicity. Moreover, our present potent antifungal armamentarium fails to eradicate fungal pathogens from certain compromised hosts. Additionally, invasive fungal diseases continue to have unacceptably high mortality rates. A growing body of work has focused on the utility of vaccines and/or immunotherapy as a powerful tool in combating mycoses, either for the active treatment, as an adjuvant, or in the prevention of specific fungal pathogens. Also, it is growing the interest over new drugs development as second choice for treatment when traditional chemotherapy fail. This Research Topic will detail the exciting progress in developing vaccines, immunotherapy and new drugs for fungi.

Nanobiotechnology in Diagnosis, Drug Delivery and Treatment

Nanobiotechnology in Diagnosis, Drug Delivery and Treatment
Author: Mahendra Rai
Publisher: John Wiley & Sons
Total Pages: 416
Release: 2020-11-17
Genre: Science
ISBN: 1119671868
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Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.