This proceedings volume contains results presented at the Sixth International Workshop on Data Analysis in Astronomy OCo OC Modeling and Simulation in ScienceOCO held on April 15-22, 2007, at the Ettore Majorana Foundation and Center for Scientific Culture, Erice, Italy. Recent progress and new trends in the field of simulation and modeling in three branches of science OCo astrophysics, biology, and climatology OCo are described in papers presented by outstanding scientists. The impact of new technologies on the design of novel data analysis systems and the interrelation among different fields are foremost in scientists'' minds in the modern era. This book therefore focuses primarily on data analysis methodologies and techniques. Sample Chapter(s). Chapter 1: Simulations for Uhe Cosmic Ray Experiments (562 KB). Contents: Astrophysics, Cosmology and Earth Physics: Simulations for UHE Cosmic Ray Experiments (J Knapp); Problems and Solutions in Climate Modeling (A Sutera); Statistical Analysis of Quasar Data and Validity of the Hubble Law (S Roy et al.); Quantum Astronomy and Information (C Barbieri); Biology, Biochemistry and Bioinformatics: From Genomes to Protein Models and Back (A Tramontano et al.); Exploring Biomolecular Recognition by Modeling and Simulation (R Wade); BioInfogrid: Bioinformatics Simulation and Modeling Based on Grid (L Milanesi); Methods and Techniques: Optimization Strategies for Modeling and Simulation (J Louchet); Biclustering Bioinformatics Data Sets: A Possibilistic Approach (F Masulli); From the Qubit to the Quantum Search Algorithms (G Cariolaro & T Occhipinti); Comparison of Stereo Vision Techniques for Cloud-Top Height Retrieval (A Anzalone et al.); and other papers. Readership: Physicists; biologists; computer scientists and data analysts."