Principles Of Safety Pharmacology
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Author | : Michael K. Pugsley |
Publisher | : Springer |
Total Pages | : 477 |
Release | : 2015-06-19 |
Genre | : Medical |
ISBN | : 366246943X |
Download Principles of Safety Pharmacology Book in PDF, Epub and Kindle
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Author | : Mary Jeanne Kallman |
Publisher | : Academic Press |
Total Pages | : 362 |
Release | : 2018-09-05 |
Genre | : Medical |
ISBN | : 0128123346 |
Download Advanced Issue Resolution in Safety Pharmacology Book in PDF, Epub and Kindle
Advanced Issue Resolution in Safety Pharmacology not only discusses unique issues that may emerge during the development of new medicines, but also provides detailed insights on how to resolve them. The book employs a valuable strategy that integrates preclinical findings with the clinical resolution of those findings. In addition, it introduces key interdisciplinary topics in an accessible and systematic format. Edited and written by leaders in the field of safety pharmacology, this book considerably advances the discussion on issue resolution topics, thus raising them to the next level of importance by providing scientists with an indispensable resource on solving safety issues. Focuses on pharmacology issues that result during drug development and provides de-risking techniques and practical advice Covers a broad selection of topics, including specialized animal models, PBPK modeling, the use of high frequency EEG in problem-solving, drug-induced self-injury, abuse potential liability, biomarkers, imaging, and much more Focuses on the resolution of these issues in order to better address regulatory expectancies and develop safer, more effective drugs
Author | : Esther Pueyo |
Publisher | : Frontiers Media SA |
Total Pages | : 385 |
Release | : 2018-08-16 |
Genre | : |
ISBN | : 2889455394 |
Download Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond Book in PDF, Epub and Kindle
Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.
Author | : Jimmy Jose |
Publisher | : Springer Nature |
Total Pages | : 557 |
Release | : |
Genre | : |
ISBN | : 3031510895 |
Download Principles and Practice of Pharmacovigilance and Drug Safety Book in PDF, Epub and Kindle
Author | : Y. James Kang |
Publisher | : |
Total Pages | : 400 |
Release | : 2006-12-01 |
Genre | : |
ISBN | : 9781597453080 |
Download Safety Pharmacology Book in PDF, Epub and Kindle
Author | : Miles Hacker |
Publisher | : Academic Press |
Total Pages | : 607 |
Release | : 2009-06-19 |
Genre | : Medical |
ISBN | : 0080919227 |
Download Pharmacology Book in PDF, Epub and Kindle
Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. Uses individual drugs to explain molecular actions Full color art program explains molecular and chemical concepts graphically Logical structure reflecting the current state of pharmacology and translational research Covers such intricacies as drug resistance and cell death Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool
Author | : Eugenia M. Fulcher |
Publisher | : Elsevier Health Sciences |
Total Pages | : 656 |
Release | : 2014-04-14 |
Genre | : Medical |
ISBN | : 0323292305 |
Download Pharmacology - E-Book Book in PDF, Epub and Kindle
Comprehensive yet easy to read, Pharmacology: Principles and Applications, 3rd Edition introduces you to basic pharmacology, showing how to apply principles to the kinds of clinical situations you will encounter on the job. You'll learn how different drugs work in the body, how to calculate drug dosages, drug administration routes and procedures, the medications related to disorders in each body system, and much more. Written by expert authors Eugenia M. Fulcher, Robert M. Fulcher, and Cathy Dubeansky Soto, Pharmacology ensures that you master all of the pharmacology competencies required by CAAHEP and ABHES. In the book and on a companion Evolve website, a variety of exercises helps you strengthen your skills in math, dosage calculation, and critical thinking. Practical coverage of basic pharmacology provides a thorough understanding of the medications most commonly used in ambulatory and inpatient settings. A real-life Scenario starts each chapter with thought-provoking questions to consider as you progress through the material. Procedures boxes provide step-by-step guidance for drug calculation and administration, accompanied by numerous illustrations and icons that identify OSHA-mandated protocols. Common Signs & Symptoms of Diseases and Common Side Effects of Medications lists in each body system chapter help you distinguish between disease progression and medication reactions. Body systems icons highlight the ways that specific drugs affect a particular body system. Chapter objectives and key words at the beginning of each chapter help you focus your study efforts. Check Your Understanding math review sections enable you to assess your knowledge of application and calculation concepts. Critical Thinking exercises challenge you to apply what you've learned to a variety of realistic situations. Important Facts and Clinical Tips boxes in each chapter highlight the key concepts for practice. Patient Education for Compliance boxes help you communicate more effectively with patients about possible side effects or adverse reactions. Summary tables are more concise and easier to follow. New calculations exercises and quizzes are included on the companion Evolve website. Expanded math and drug calculation sections in the workbook supplement the textbook with additional exercises for practice with math and dosage calculations. Available separately.
Author | : |
Publisher | : |
Total Pages | : |
Release | : 2001 |
Genre | : |
ISBN | : |
Download Guidance for Industry Book in PDF, Epub and Kindle
Author | : John Talbot |
Publisher | : John Wiley & Sons |
Total Pages | : 751 |
Release | : 2011-10-28 |
Genre | : Medical |
ISBN | : 1119952107 |
Download Stephens' Detection and Evaluation of Adverse Drug Reactions Book in PDF, Epub and Kindle
The detection and evaluation of adverse drug reactions is crucial for understanding the safety of medicines and for preventing harm in patients. Not only is it necessary to detect new adverse drug reactions, but the principles and practice of pharmacovigilance apply to the surveillance of a wide range of medicinal products. Stephens' Detection and Evaluation of Adverse Drug Reactions provides a comprehensive review of all aspects of adverse drug reactions throughout the life cycle of a medicine, from toxicology and clinical trials through to pharmacovigilance, risk management, and legal and regulatory requirements. It also covers the safety of biotherapeutics and vaccines and includes new chapters on pharmacogenetics, proactive risk management, societal considerations, and the safety of drugs used in oncology and herbal medicines. This sixth edition of the classic text on drug safety is an authoritative reference text for all those who work in pharmacovigilance or have an interest in adverse drug reactions, whether in regulatory authorities, pharmaceutical companies, or academia. Praise for previous editions "This book presents a comprehensive and wide-ranging overview of the science of pharmacovigilance. For those entering or already experienced in the pharmaceutical sciences, this is an essential work.” - from a review in E-STREAMS "...a key text in the area of pharmacovigilance...extensively referenced and well-written...a valuable resource..." - from a review in The Pharmaceutical Journal
Author | : A. Wallace Hayes |
Publisher | : CRC Press |
Total Pages | : 2296 |
Release | : 2007-09-25 |
Genre | : Medical |
ISBN | : 1420005421 |
Download Principles and Methods of Toxicology Book in PDF, Epub and Kindle
Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanis