The preparation, characterization and application of electrodes with specific chemical properties that are imparted by surface modification with polymer networks are the long-range goals of this research. Networks that are formed by crosslinking with gamma radiation have been evaluated with respect to swelling in aqueous solution, retention of polymer in the network, permeability, and the effect of radiation dosage on all of these properties through its control of crosslinking. Ionic water-soluble polymers such as polyDIALLYL DIMETHYL AMMONIUM CHOLRIDE, poly VINYLBENZYL TRIMETHYL AMMONIUM CHLORIDE, ploySTYRENE SULFONIC ACID, SODIUM SALT and polyACRYLIC ACID, which would ordinarily dissolve from the electrode surface in aqueous solution unless crosslinked into a network, and several neutral polymers such as polyACRLYONITRILE, polyETHYLENEIMINE, polyDIMETHYLSILOXANE and poly VINYL ALCOHOL have been investigated. The covalent attachment of organic and inorganic redox mediators and enzymes to networks by gamma irradiation of a mixture of polymer and the agent have been investigated. Network-coated electrodes with the appropriate properties are being developed for specific applications that required a stable, easily fabricated, fouling-resistant, rapidly responding, sensitive, and selective electrode.