Potassium Channel Modulators
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Author | : John M Evans |
Publisher | : CRC Press |
Total Pages | : 521 |
Release | : 2003-09-02 |
Genre | : Science |
ISBN | : 0203304411 |
Download Potassium Channels And Their Modulators Book in PDF, Epub and Kindle
Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.
Author | : AH Weston |
Publisher | : Wiley-Blackwell |
Total Pages | : 528 |
Release | : 1993-01-18 |
Genre | : Medical |
ISBN | : 9780632030446 |
Download Potassium Channel Modulators Book in PDF, Epub and Kindle
Modulation of potassium channels plays a very important part in nerve cell function in the autonomic nervous system. Compounds are now in development which can open or close potassium channels and will have numerous therapeutic applications. The major areas of clinical relevance will be hypertension, asthma and irritable bladder syndrome. The book describes the pharmacology of the channels and strategies for the design of drugs which exploit them. It consists of 17 chapters by international experts in the field which are written at a high level and will be of interest to pharmacologists and those in related clinical research disciplines
Author | : Jeffrey Noebels |
Publisher | : OUP USA |
Total Pages | : 1258 |
Release | : 2012-06-29 |
Genre | : Medical |
ISBN | : 0199746540 |
Download Jasper's Basic Mechanisms of the Epilepsies Book in PDF, Epub and Kindle
Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Author | : Noel John Chambers |
Publisher | : |
Total Pages | : 350 |
Release | : 1994 |
Genre | : Potassium channels |
ISBN | : |
Download Synthesis and Development of Potassium Channel Modulators Book in PDF, Epub and Kindle
Author | : National Institute of Neurological and Communicative Disorders and Stroke. Epilepsy Branch |
Publisher | : |
Total Pages | : 26 |
Release | : 1978 |
Genre | : Anticonvulsants |
ISBN | : |
Download Anticonvulsant Screening Project Book in PDF, Epub and Kindle
Author | : Nikita Gamper |
Publisher | : Springer Nature |
Total Pages | : 546 |
Release | : 2021-09-27 |
Genre | : Medical |
ISBN | : 3030840522 |
Download Pharmacology of Potassium Channels Book in PDF, Epub and Kindle
The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.
Author | : David J. Triggle |
Publisher | : John Wiley & Sons |
Total Pages | : 492 |
Release | : 2006-08-21 |
Genre | : Science |
ISBN | : 3527607749 |
Download Voltage-Gated Ion Channels as Drug Targets Book in PDF, Epub and Kindle
Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.
Author | : Chi-Kong Yeung |
Publisher | : |
Total Pages | : 289 |
Release | : 1997 |
Genre | : |
ISBN | : |
Download Characteristics of the Effects of Potassium Channel Modulators on Murine Gastrointestinal Smooth Muscle Book in PDF, Epub and Kindle
The aim of this work was to investigate the actions of potassium channel modulating agents on the motility of the gastrointestinal tract of mice in vitro and in vivo. .....
Author | : Simone Furini |
Publisher | : Springer Nature |
Total Pages | : 298 |
Release | : |
Genre | : |
ISBN | : 1071638181 |
Download Potassium Channels Book in PDF, Epub and Kindle
Author | : Brian Cox |
Publisher | : Royal Society of Chemistry |
Total Pages | : 385 |
Release | : 2014-09-03 |
Genre | : Science |
ISBN | : 1849735085 |
Download Ion Channel Drug Discovery Book in PDF, Epub and Kindle
Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.