Approaches to Design and Synthesis of Antiparasitic Drugs

Approaches to Design and Synthesis of Antiparasitic Drugs
Author: N. Anand
Publisher: Elsevier
Total Pages: 525
Release: 1997-07-10
Genre: Medical
ISBN: 0080527523

Download Approaches to Design and Synthesis of Antiparasitic Drugs Book in PDF, Epub and Kindle

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Polyamines in Health and Nutrition

Polyamines in Health and Nutrition
Author: Susan Bardocz
Publisher: Springer Science & Business Media
Total Pages: 360
Release: 1999-06-30
Genre: Science
ISBN: 9780412822209

Download Polyamines in Health and Nutrition Book in PDF, Epub and Kindle

The importance of polyamines for all living cells has been recognized since spermine was discovered in human semen more than 300 years ago. Polyamine research intensified when analytical methods were developed for their determination, particularly in tissues and biological fluids. Discovering their close correlation with cancer, and that polyamine concentrations change during the cell cycle, gave reason for further research in this topic. Polyamines in Health and Nutrition concentrates on the direction of polyamine research which has the capacity to influence and benefit our health and which can explain some of the discrepancies and failures of earlier research. It is important to recognize the dietary contribution to the polyamine body pool and to investigate how the polyamine content of the diet can be changed, with the ultimate aim of using this information to improve our health.

Comprehensive Supramolecular Chemistry II

Comprehensive Supramolecular Chemistry II
Author: George W. Gokel
Publisher: Elsevier
Total Pages: 4627
Release: 2017-06-22
Genre: Science
ISBN: 0128031999

Download Comprehensive Supramolecular Chemistry II Book in PDF, Epub and Kindle

Comprehensive Supramolecular Chemistry II, Second Edition, Nine Volume Set is a ‘one-stop shop’ that covers supramolecular chemistry, a field that originated from the work of researchers in organic, inorganic and physical chemistry, with some biological influence. The original edition was structured to reflect, in part, the origin of the field. However, in the past two decades, the field has changed a great deal as reflected in this new work that covers the general principles of supramolecular chemistry and molecular recognition, experimental and computational methods in supramolecular chemistry, supramolecular receptors, dynamic supramolecular chemistry, supramolecular engineering, crystallographic (engineered) assemblies, sensors, imaging agents, devices and the latest in nanotechnology. Each section begins with an introduction by an expert in the field, who offers an initial perspective on the development of the field. Each article begins with outlining basic concepts before moving on to more advanced material. Contains content that begins with the basics before moving on to more complex concepts, making it suitable for advanced undergraduates as well as academic researchers Focuses on application of the theory in practice, with particular focus on areas that have gained increasing importance in the 21st century, including nanomedicine, nanotechnology and medicinal chemistry Fully rewritten to make a completely up-to-date reference work that covers all the major advances that have taken place since the First Edition published in 1996

A Guide to the Polyamines

A Guide to the Polyamines
Author: Seymour Stanley Cohen
Publisher: Oxford University Press, USA
Total Pages: 632
Release: 1998
Genre: Science
ISBN:

Download A Guide to the Polyamines Book in PDF, Epub and Kindle

The polyamines are ubiquitous and essential organic cations in prokaryotic and eukaryotic cells. This book is a comprehensive survey of the development of knowledge of their physiological and structural roles. Currently, the genetic and regulatory determinants of the amines and their cellular composition are being explored actively as parameters of normal physiology and aberrant pathologies. Cancer, virus infection, and protozoan parasitism are major examples of the later groups. Studies of the control of polyamine metabolism are providing important therapeutic leads. Further, the structural roles of the amines are being determined at molecular levels, contributing to the understanding of polynucleotide and protein organization and interaction, as well as to the solution of problems of genome transfer. These subjects describe a burgeoning biochemical area involving compounds whose roles in cytoplasmic and nuclear function include numerous aspects of organelle structure, polymer synthesis, and interactions.

Polyamine Protocols

Polyamine Protocols
Author: David M. L. Morgan
Publisher: Springer Science & Business Media
Total Pages: 173
Release: 2008-02-02
Genre: Science
ISBN: 1592595650

Download Polyamine Protocols Book in PDF, Epub and Kindle

A unique collection of hands-on enzyme assay techniques to study polyamines and their function. The techniques range from assay methods for enzymes of polyamine biosynthesis and catabolism to measurements of polyamines, polyamine transport, and polyamine effects on cell growth. The methods are presented by leading researchers who have perfected them to a high art, and include clear, step-by-step instructions with numerous hints and tips to ensure readily reproducible results.

Polyamines

Polyamines
Author: Kazutomo Imahori
Publisher: VSP
Total Pages: 548
Release: 1985-12
Genre: Science
ISBN: 9789067640428

Download Polyamines Book in PDF, Epub and Kindle

The significance of polyamines in cell proliferation and carcinogenesis has stimulated further research interest in their biochemistry and metabolism. These papers, which update the available literature on polyamines, are grouped into four main areas: the metabolism of polyamines; the effect of polyamines on cellular metabolism; inhibitors of polyamine metabolism and their clinical relevance; application to diagnosis and prognosis. The Proceedings include contributions from a wide range of research interests with special emphasis being placed on the clinical aspects of these compounds.

The Genus Yersinia:

The Genus Yersinia:
Author: Robert D. Perry
Publisher: Springer Science & Business Media
Total Pages: 454
Release: 2007-09-25
Genre: Medical
ISBN: 0387721231

Download The Genus Yersinia: Book in PDF, Epub and Kindle

The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field.

Inhibition of Polyamine Metabolism

Inhibition of Polyamine Metabolism
Author: Peter P. McCann
Publisher:
Total Pages: 400
Release: 1987
Genre: Science
ISBN:

Download Inhibition of Polyamine Metabolism Book in PDF, Epub and Kindle

Inhibition of polyamine metabolism ...

Polyamines

Polyamines
Author: Tomonobu Kusano
Publisher: Springer
Total Pages: 324
Release: 2015-01-07
Genre: Science
ISBN: 443155212X

Download Polyamines Book in PDF, Epub and Kindle

This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.

Polyamines in Biomedical Research

Polyamines in Biomedical Research
Author: Joseph M. Gaugas
Publisher: John Wiley & Sons
Total Pages: 500
Release: 1980
Genre: Medical
ISBN:

Download Polyamines in Biomedical Research Book in PDF, Epub and Kindle