Phosphodiesterases
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| Author | : Joseph A. Beavo |
| Publisher | : CRC Press |
| Total Pages | : 728 |
| Release | : 2006-12-05 |
| Genre | : Medical |
| ISBN | : 1420020846 |
Download Cyclic Nucleotide Phosphodiesterases in Health and Disease Book in PDF, Epub and Kindle
Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
| Author | : XiaoDong Cheng |
| Publisher | : CRC Press |
| Total Pages | : 288 |
| Release | : 2021-03-30 |
| Genre | : Cellular signal transduction |
| ISBN | : 9780367658809 |
Download Cyclic Nucleotide Signaling Book in PDF, Epub and Kindle
Showcasing the recent progresses of the field, Cyclic Nucleotide Signaling covers the major tools and methodologies used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Students and investigators new to the field will find this book particularly informative, as will scientists already actively researching nucleotide signaling.
| Author | : Christian Schudt |
| Publisher | : Academic Press |
| Total Pages | : 266 |
| Release | : 1996-08-27 |
| Genre | : Medical |
| ISBN | : |
Download Phosphodiesterase Inhibitors Book in PDF, Epub and Kindle
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike
| Author | : Sharron H. Francis |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 531 |
| Release | : 2011-06-21 |
| Genre | : Medical |
| ISBN | : 364217969X |
Download Phosphodiesterases as Drug Targets Book in PDF, Epub and Kindle
Cyclic nucleotide phosphodiesterases (PDEs) are promising targets for pharmacological intervention. Multiple PDE genes, isoform diversity, selective expression and compartmentation of the isoforms, and an array of conformations of PDE proteins are properties that challenge development of drugs that selectively target this class of enzymes. Novel characteristics of PDEs are viewed as unique opportunities to increase specificity and selectivity when designing novel compounds for certain therapeutic indications. This chapter provides a summary of the major concepts related to the design and use of PDE inhibitors.
| Author | : Hyman J. Zimmerman |
| Publisher | : Lippincott Williams & Wilkins |
| Total Pages | : 848 |
| Release | : 1999 |
| Genre | : Medical |
| ISBN | : 9780781719520 |
Download Hepatotoxicity Book in PDF, Epub and Kindle
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
| Author | : Nicholas J. Brandon |
| Publisher | : John Wiley & Sons |
| Total Pages | : 429 |
| Release | : 2014-03-07 |
| Genre | : Medical |
| ISBN | : 1118836308 |
Download Cyclic-Nucleotide Phosphodiesterases in the Central Nervous System Book in PDF, Epub and Kindle
This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
| Author | : Spiros Liras |
| Publisher | : John Wiley & Sons |
| Total Pages | : 280 |
| Release | : 2014-03-03 |
| Genre | : Medical |
| ISBN | : 3527682368 |
Download Phosphodiesterases and Their Inhibitors Book in PDF, Epub and Kindle
Written by the pioneers of Viagra, the first blockbuster PDE inhibitor drug. Beginning with a review of the first wave of phosphodiesterase (PDE) inhibitors, this book focuses on new and emerging PDE targets and their inhibitors. Drug development options for all major human PDE families are discussed and cover diverse therapeutic fields, such as neurological/psychiatric, cardiovascular/metabolic, pain, and allergy/respiratory diseases. Finally, emerging chemotherapeutic applications of PDE inhibitors against malaria and other tropical diseases are discussed.
| Author | : Han-Ting Zhang |
| Publisher | : Springer |
| Total Pages | : 475 |
| Release | : 2017-09-26 |
| Genre | : Medical |
| ISBN | : 3319588117 |
Download Phosphodiesterases: CNS Functions and Diseases Book in PDF, Epub and Kindle
PDEs are a family of enzymes that catalyze the hydrolysis of intracellular cyclic nucleotides. They are implicated in a number of disorders and dysfunctions and PDE inhibitors have already proven to be effective therapies for erectile dysfunction, COPD, and psoriatic arthritis. This family of enzymes also plays a role in diseases and disorders of the CNS such as depression, anxiety, schizophrenia, and Alzheimer's Disease. Unfortunately no effective PDE inhibitors have been developed for the treatment of these diseases. The proposed book will be a comprehensive overview of the current state of basic and translational research on PDE inhibitors written by internationally recognized experts. Authors will also discuss potential PDE subtypes and splice variants in the hopes that this will spur more creative approaches to PDE targeting drugs.
| Author | : Claire Lugnier |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 327 |
| Release | : 2008-02-04 |
| Genre | : Science |
| ISBN | : 1592598390 |
Download Phosphodiesterase Methods and Protocols Book in PDF, Epub and Kindle
Research leaders in the PDE field describe new concepts and techniques for investigating the role of PDEs in orchestrating normal and pathophysiological responses. Presented in step-by-step detail, these readily reproducible methods allow the measurement of cyclic nucleotide variations in living cells, as well as their visualization in a spatio-temporal manner, the localization and characterization of their activities in tissues and living cells, and the assessment of targeted PDEs in creating specific tools and drugs.
| Author | : |
| Publisher | : Elsevier |
| Total Pages | : 247 |
| Release | : 1996-08-16 |
| Genre | : Science |
| ISBN | : 0080538819 |
Download Phosphodiesterase Inhibitors Book in PDF, Epub and Kindle
Non-selective inhibitors of cyclic nucleotide phosphodiesterase (PDE), such as theophylline, have been used extensively since 1958. In the decade of the '70s, various PDE isoenzymes were defined which led to the development of the second generation of PDE inhibitors. Currently a variety of these new inhibitors are under test as potential anti-inflammatory drugs. During the past five years, molecular biology has revealed a superfamily of these phosphodiesterase isoenzymes. This book summarizes the present state of knowledge, as well as giving a comprehensive description of the compounds available. It will be invaluable for everyone who wants to choose the most suitable PDE inhibitor for their research or who is dealing with such drugs in a clinical setting. Utilizes actual testing and research of new PDE inhibitors Valuable for researchers and students alike
