Palladium(II)-catalyzed Regiospecific and Stereospecific Cycloaddition Reactions of Aziridines and Azetidines with Heterocumulenes

Palladium(II)-catalyzed Regiospecific and Stereospecific Cycloaddition Reactions of Aziridines and Azetidines with Heterocumulenes
Author: Jin-Ook Baeg
Publisher:
Total Pages: 0
Release: 1994
Genre: Palladium catalysts
ISBN:

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On the basis of results obtained, including spectroscopic studies and X-ray analysis, a mechanism has been proposed for the cycloaddition reactions of the N-heterocycles with heterocumulenes. A bis(azetidine)palladium complex was isolated and shown to be catalytically active for the reaction of azetidines with heterocumulenes. Numerous heterocyclic compounds have been prepared for the first time, some of them having the potential for pharmacological activity.

Reaction Mechanisms in Carbon Dioxide Conversion

Reaction Mechanisms in Carbon Dioxide Conversion
Author: Michele Aresta
Publisher: Springer
Total Pages: 423
Release: 2015-11-07
Genre: Science
ISBN: 366246831X

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This book provides an analysis of the reaction mechanisms relevant to a number of processes in which CO2 is converted into valuable products. Several different processes are considered that convert CO2 either in specialty chemicals or in bulk products or fuels. For each reaction, the mechanism is discussed and the assessed steps besides the dark sites of the reaction pathway are highlighted. From the insertion of CO2 into E-X bonds to the reduction of CO2 to CO or other C1 molecules or else to C2 or Cn molecules, the reactions are analysed in order to highlight the known and obscure reaction steps. Besides well known reaction mechanisms and energy profiles, several lesser known situations are discussed. Advancing knowledge of the latter would help to develop efficient routes for the conversion of CO2 into valuable products useful either in the chemical or in the energy industry. The content of this book is quite different from other books reporting the use of CO2. On account of its clear presentation, “Reaction Mechanisms in Carbon Dioxide Conversion” targets in particular researchers, teachers and PhD students.

Green Synthetic Approaches for Biologically Relevant Heterocycles

Green Synthetic Approaches for Biologically Relevant Heterocycles
Author: Goutam Brahmachari
Publisher: Elsevier
Total Pages: 642
Release: 2021-02-26
Genre: Science
ISBN: 0128205865

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Green Synthetic Approaches for Biologically Relevant Heterocycles, Second Edition, Volume One: Advanced Synthetic Techniques reviews this significant group of organic compounds within the context of sustainable methods and processes, expanding on the first edition with fully updated coverage and a whole range of new chapters. Volume One explores advanced synthetic techniques, with each chapter presenting in-depth coverage of various green protocols for the synthesis of a wide variety of bioactive heterocycles that are classified on the basis of ring-size and/or the presence of heteroatoms. Techniques covered range from high pressure cycloaddition reactions and microwave irradiation to sustainable one-pot domino reactions. This updated edition is an essential resource on sustainable approaches for academic researchers, R&D professionals, and students working across medicinal, organic, natural product and green chemistry. Provides fully updated coverage of the field of greener heterocycle synthesis Includes new chapters on varied multicomponent reactions, alongside both traditional and novel approaches Presents information in an accessible style with an emphasis on sustainability

Aziridines and Epoxides in Organic Synthesis

Aziridines and Epoxides in Organic Synthesis
Author: Andrei K. Yudin
Publisher: John Wiley & Sons
Total Pages: 532
Release: 2006-02-20
Genre: Science
ISBN: 9783527312139

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Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.

Neurotransmitters and Neuromodulators

Neurotransmitters and Neuromodulators
Author: Oliver von Bohlen und Halbach
Publisher: John Wiley & Sons
Total Pages: 402
Release: 2006-12-13
Genre: Medical
ISBN: 3527609075

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A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.

Chemistry of 2-Oxoaldehydes and 2-Oxoacids

Chemistry of 2-Oxoaldehydes and 2-Oxoacids
Author: Atul Kumar
Publisher: Elsevier
Total Pages: 293
Release: 2021-09-28
Genre: Science
ISBN: 0128242868

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Chemistry of 2-Oxoaldehydes and 2-Oxoacids offers complete coverage on 2-oxoaldehydes and 2-oxoacid, which to date have not been covered in a comprehensive manner. Novel reactions related to 2-oxoaldehydes and 2-oxoacids on keto and aldehydic groups (both participating separately or in combination), decarboxylative reactions, spectral analysis and diverse applications are explored. The book is divided into two parts, with the first outlining methods for the preparation and physical properties of 2-Oxoaldehydes, along with the structure, spectral characteristics and reactivity of 2-Oxoaldehydes. The second part covers the preparation and physical properties of 2-Oxoacids and the synthesis of many related reactions. This book is essential reading for researchers working on these types of reactions in organic chemistry, medicinal chemistry, natural product chemistry and pharmaceutical chemistry. Covers various synthetic procedures for the synthesis of 2-Oxoaldehydes and 2-Oxoacids Provides information about different types of reactions, such as C-H activation reactions, coupling reactions, decarboxylative reactions, and nucleophilic reactions for the synthesis of different biologically active compounds Includes the use of 2-Oxoaldeehyde and 2-Oxoacid as the starting point for the synthesis of different synthons that can be used for various medicinally important compounds

Synthesis of 4- to 7-membered Heterocycles by Ring Expansion

Synthesis of 4- to 7-membered Heterocycles by Ring Expansion
Author: Matthias D’hooghe
Publisher: Springer
Total Pages: 376
Release: 2015-12-14
Genre: Science
ISBN: 3319249606

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The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Prodrug Design

Prodrug Design
Author: Vivekkumar K Redasani
Publisher: Academic Press
Total Pages: 84
Release: 2015-07-07
Genre: Science
ISBN: 0128035579

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Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference. Offers unique, detailed overview of Prodrug research and literature Provides detailed chemical structures Includes Prodrug listing by therapeutic area

Comprehensive Chirality

Comprehensive Chirality
Author:
Publisher: Newnes
Total Pages: 5635
Release: 2012-12-31
Genre: Science
ISBN: 0080951686

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Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Medical Toxicology of Drug Abuse

Medical Toxicology of Drug Abuse
Author: Donald G. Barceloux
Publisher: John Wiley & Sons
Total Pages: 1080
Release: 2012-02-03
Genre: Science
ISBN: 1118106059

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This book provides a broad reference covering important drugs of abuse including amphetamines, opiates, and steroids. It also covers psychoactive plants such as caffeine, peyote, and psilocybin. It provides chemical structures, analytical methods, clinical features, and treatments of these drugs of abuse, serving as a highly useful, in-depth supplement to a general medical toxicology book. The style allows for the easy application of the contents to searchable databases and other electronic products, making this an essential resource for practitioners in medical toxicology, industrial hygiene, occupational medicine, pharmaceuticals, environmental organizations, pathology, and related fields.