The structures making up airframes must be durable and damage tolerant, and the means of ensuring that they are have long been well defined for structures made of metal. But a host of new hybrid materials, some of which contain no metal, are now being used, and these can present new damage mechanisms that engineers must address. The Air Force has established a general approach to airframe durability and damage tolerance. The author examines that approach and considers ways it will need to adapt for the new materials. Given the variety of materials, processes, and end uses involved, the engineering effort will necessarily involve multiple specialties. In these circumstances, the tailoring process could benefit from the efforts of systems engineers. The report addresses both technical and programmatic concerns and identifies opportunities for materials and structural engineers to collaborate with systems engineers. Finally, it offers a framework for collaboration.