One Hundred And Twenty Seven Cultured Human Tumor Cell Lines Producing Tumors In Nude Mice
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Author | : J Fogh |
Publisher | : |
Total Pages | : |
Release | : 1977 |
Genre | : |
ISBN | : |
Download One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice Book in PDF, Epub and Kindle
Author | : Jorgen Fogh |
Publisher | : Springer Science & Business Media |
Total Pages | : 568 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 1475716478 |
Download Human Tumor Cells in Vitro Book in PDF, Epub and Kindle
The study of cultured human tumor cells is a most obvious approach in experimental human cancer research. For many techniques in virology, immunology, biochemistry, and biophysics, for example, large amounts of cells may be required and such quantities are usually provided only when the cultures develop into established cell lines; when this happens, thorough characterization also becomes possible. The development of cell lines, therefore, is of prime importance. Recent major advances in research with animal cell systems see m to be a prologue for present and future efforts directed toward work with human tumor cells in culture. Conceivably, the most significant results in cancer research may develop from work with such cells, and so the time seemed right to define the present state of our knowledge. This is the first book dedicated exclusively to the subject: human tumor cells in vitro. Although so me of the fundamental aspects in the cultivation of human tumor ceIls, and the extent to which they represent human cancer in vivo are still unclear, I asked a number of the leading investigators in this area of research to collect and evaluate previous and present contributions, and to offer their thoughts on the questions to which answers are not yet available. Many of the chapters are concerned with techniques of cultivation. Cultures from some types of tumors have grown weIl; in many cases they have given rise to established cell lines.
Author | : C.T. Griffiths |
Publisher | : Springer Science & Business Media |
Total Pages | : 398 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1461338522 |
Download Gynecologic Oncology Book in PDF, Epub and Kindle
At the turn of the century gynecology had achieved independence from surgery in most medical schools; although gynecologists were surgeons, their interests were turning toward nonsurgical aspects of their specialty. In 1900, merely two years after the Curies' discovery, radium was first used as a treatment for carcinoma of the cervix. In that day cervical cancer claimed more women's lives than any other malignancy and was described by Wil liam P. Graves, the second professor of gynecology at Harvard as follows: 'Cancer of the cervix may rightly be termed of all tumors one of the most deadly and most ghastly. It kills by slow torture, causing in later stages months of agonizing pain and producing a discharge of such a foul and nauseating character as to repel proper medical assistance. Nurses declined to care for these cases, while many public hospitals closed their wards to them as patients. ' In late twentieth century parlance the dramatic results of radium therapy would indeed have been called a 'breakthrough'? and radium techniques, later combined with external irradiation, were devel oped by gynecologists, no longer just surgeons. Pathology was the basic science of gynecology and gynecologists with a special interest in pathology served as pathologist to the departments of gynecology. As late as 1970 six months of the three-year residency program in obstetrics and gynecology at Harvard were devoted to formal training in pathology.
Author | : Robert K.M. Hay |
Publisher | : Academic Press |
Total Pages | : 503 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 1483288625 |
Download Atlas of Human Tumor Cell Lines Book in PDF, Epub and Kindle
Human tumor cells in culture are valuable for studying cancer causes and properties. This convenient reference provides useful information for cancer researchers on commonly used, established tumor cell lines of the major human organ systems. Atlas of Human Tumor Cell Lines includes data about morphological, metabolic, genetic, and growth characteristics of human tumor cells, with morphological characteristics presented in more than 250 photomicrographs. It also contains information for establishing and maintaining human tumor cell lines in culture, and each chapter covers future perspectives. Covers well-characterized tumor cell lines from the major human organ systems Presents over 250 photomicrographs, both phase-contrast and electron micrographs Includes a list of key references for each chapter Written by world-renowned experts
Author | : Beverly A. Teicher |
Publisher | : Springer Science & Business Media |
Total Pages | : 514 |
Release | : 2004-02-01 |
Genre | : Medical |
ISBN | : 1592597394 |
Download Anticancer Drug Development Guide Book in PDF, Epub and Kindle
This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
Author | : |
Publisher | : |
Total Pages | : 354 |
Release | : 2001-07 |
Genre | : Cancer |
ISBN | : |
Download Journal of the National Cancer Institute Book in PDF, Epub and Kindle
Author | : Epie Boven |
Publisher | : CRC Press |
Total Pages | : 350 |
Release | : 2018-01-18 |
Genre | : Medical |
ISBN | : 1351085662 |
Download The Nude Mouse in Oncology Research Book in PDF, Epub and Kindle
The nude, athymic mouse (nu/nu) has become generally accepted as a valuable tool to study the biology and therapy of human cancers. This volume presents a critical review of the scientific merits of the animal as a recipient of human tumor tissue transplants. Important information is provided regarding biology, immunology, and measures for genetic and microbiological control of the nude mouse. The discussion of transplantation sites and transplantability of human tumor tissue to the animals includes both the description of host factors and the tumor type involved. The characterization and monitoring of xenografts is followed by a review on their possible application for studies in tumor biology, such as hormones, growth factors, drug resistance, tumor markers, and heterogeneity. Experimental therapy is dedicated to cytostatic agents, hormones, monoclonal antibodies, cytokines, differentiation inducers and radiotherapy. The book also provides critical remarks regarding the limitation of the nude-mouse tumor models. The Nude Mouse in Oncology Research will provide essential reference information for oncology researchers, researchers who work with the nude mouse on a regular basis, and pharmaceutical companies.
Author | : National Cancer Institute (U.S.) |
Publisher | : |
Total Pages | : 1092 |
Release | : 1977-07 |
Genre | : Cancer |
ISBN | : |
Download Journal Book in PDF, Epub and Kindle
Author | : Roswitha Pfragner |
Publisher | : John Wiley & Sons |
Total Pages | : 453 |
Release | : 2005-03-11 |
Genre | : Science |
ISBN | : 0471270628 |
Download Culture of Human Tumor Cells Book in PDF, Epub and Kindle
Ein neuer Band aus der 'Culture of Specialized Cells'-Reihe. Leserfreundlich aufgemacht. Er vermittelt spezifische praktische Details, wie man Medien und Reagenzien sowie Protokolle für Zellisolierung und Zellkultur präpariert. Logisch aufgebaut und nach spezifischen Tumoren gegliedert. Farbtafeln demonstrieren anschaulich Immunozytochemie und Fluoreszenz in situ Hybridisierung (FISH). Darüber hinaus beschreibt das Buch auch umfangreiche Sicherheitsvorkehrungen. Mit einer Vielzahl nützlicher Tipps. Mit einem Glossar zu ausgewählten Fachtermini. Enthält eine umfangreiche Liste mit Bezugsadressen von Ausrüstung und Zellkulturprodukten. Erläutert medikamentöse Behandlung, Auswahl, Differenzierung, Assays für die Untersuchung maligner Zellen sowie Risiken und Anwendungsmöglichkeiten.
Author | : |
Publisher | : |
Total Pages | : 428 |
Release | : 1978 |
Genre | : Cancer |
ISBN | : |
Download Workshop on Genitourinary Cancer Immunology Book in PDF, Epub and Kindle