OECD Series on Testing and Assessment New Scoping Document on in vitro and ex vivo Assays for the Identification of Modulators of Thyroid Hormone Signalling

OECD Series on Testing and Assessment New Scoping Document on in vitro and ex vivo Assays for the Identification of Modulators of Thyroid Hormone Signalling
Author: OECD
Publisher: OECD Publishing
Total Pages: 148
Release: 2014-07-11
Genre:
ISBN: 9264274715
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This scoping document aims at bringing forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, to provide recommendations for their development/use, and also, to identify aspects/blocks of the thyroid signalling pathways that are not covered and would ...

OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption

OECD Series on Testing and Assessment Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption
Author: OECD
Publisher: OECD Publishing
Total Pages: 692
Release: 2018-09-03
Genre:
ISBN: 9264304746
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This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.

OECD Series on Testing and Assessment Guidance Document for Describing Non-Guideline In Vitro Test Methods

OECD Series on Testing and Assessment Guidance Document for Describing Non-Guideline In Vitro Test Methods
Author: OECD
Publisher: OECD Publishing
Total Pages: 17
Release: 2017-04-13
Genre:
ISBN: 9264274731
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The purpose of this guidance is to harmonise the way non-guideline in vitro methods are described and thereby facilitate an assessment of the relevance of test methods for biological activities and responses of interest, and an assessment of the quality of data produced, irrespective of whether ...

Endocrine Disruption and Human Health

Endocrine Disruption and Human Health
Author: Philippa D. Darbre
Publisher: Academic Press
Total Pages: 536
Release: 2021-09-19
Genre: Medical
ISBN: 0128219882
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Updated with new and expanded chapters, Endocrine Disruption and Human Health, Second Edition provides an introduction to what endocrine disruptors are, the issues surrounding them, the source of these chemicals in the ecosystem and the mechanisms of action and assay systems. Contributions by specialists are included to discuss the varying effects of endocrine disruption on human health, and procedures for risk assessment of endocrine disruptors, and current approaches to their regulation are also covered. With new material on topics such as low-term, low dose mixtures, windows of susceptibility, epigenetics, EDCs effect on the gut microbiome, EDCs in from polluted air and oral exposures, green chemistry, and nanotechnology, the new edition of Endocrine Disruption and Human Health is a valuable and informative text for academic and clinical researchers and other health professionals approaching endocrine disruption and its effects on human health for the first time, graduate students, and advanced undergraduate students. Provides readers with access to a range of information from the basic mechanisms and assays through to cutting-edge research investigating concerns for human health Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations Newly added content on topics like low-term, low dose mixtures, windows of susceptibility to EDCs, EDCs effect on the gut microbiome, green chemistry, and nanotechnology

Toxicology and Risk Assessment

Toxicology and Risk Assessment
Author: Helmut Greim
Publisher: John Wiley & Sons
Total Pages: 842
Release: 2018-08-10
Genre: Science
ISBN: 1119135923
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Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.

Hayes' Principles and Methods of Toxicology

Hayes' Principles and Methods of Toxicology
Author: A. Wallace Hayes
Publisher: CRC Press
Total Pages: 2143
Release: 2023-07-03
Genre: Medical
ISBN: 1000875776
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Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.

Toxicology for the Health and Pharmaceutical Sciences

Toxicology for the Health and Pharmaceutical Sciences
Author: Antonio Peña-Fernández
Publisher: CRC Press
Total Pages: 531
Release: 2021-12-21
Genre: Medical
ISBN: 1351398016
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There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in the public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal in addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. Key Features: Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.

European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment

European Partnership on the Assessment of Risks from Chemicals (PARC): Focus on New Approach Methodologies (NAMs) in Risk Assessment
Author: Terje Svingen
Publisher: Frontiers Media SA
Total Pages: 125
Release: 2024-08-21
Genre: Medical
ISBN: 2832553389
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The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in 2022. The overarching aim of this partnership is to enhance our knowledge about chemical substances to better safeguard human health and the environment against harmful effects. The project will run for seven years under Horizon Europe. PARC is subdivided into several work packages (WPs). WP5 is focused on hazard assessment for human and environmental health and includes more than 80 partners across Europe. WP5 aims to fill data gaps for specified chemical substances of concern (e.g, bisphenol alternatives) and to develop or improve new approach methodologies (NAMs) for chemical hazard assessment. This is in order to progress towards a risk assessment paradigm relying less on animal toxicity data, both with respect to human health and environmental safety. As the PARC initiative will evolve over time with respect to both projects and activities, presenting early initiatives will foster an increased awareness of ongoing activities and potential incorporation of new activities going forward.

Validation of a Battery of Mechanistic Methods Relevant for the Detection of Chemicals that Can Disrupt the Thyroid Hormone System

Validation of a Battery of Mechanistic Methods Relevant for the Detection of Chemicals that Can Disrupt the Thyroid Hormone System
Author:
Publisher:
Total Pages: 0
Release: 2023
Genre:
ISBN: 9789268012574
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Chemicals that can disrupt the thyroid hormone (TH) system can be found in everyday products and are considered to be endocrine disruptors (EDs). For more than thirty years, the European Union (EU) has been working on EDs and has introduced legislative obligations aimed at phasing out EDs in water, industrial chemicals, plant protection products and biocides. This has so far led to the availability of in vitro test methods able to detect estrogen and androgen active chemicals. In 2014, the Organisation for Economic Co-operation and Development (OECD) published the New Scoping Document on in vitro and ex vivo assays for the identification of modulators of thyroid hormone signalling. In line with the European Commission's policy on EDs and taking into account the information reported in the OECD scoping document, the European Commission's European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) launched a validation study to validate a battery of thyroid-relevant mechanistic methods, which could be used as test methods within the OECD test guideline framework. In this validation study report, the organisation of the validation study, the mechanistic relevance of the assessed in vitro new approach methods (NAMs) and the achievements are described. The validation effort, complemented with efforts at international level, is aimed at contributing to mechanistic NAM data generation to support global regulatory processes to identify endocrine disrupting substances.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper on Amphibian Metamorphosis Assay for the Detection of Thyroid Active Substances

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Detailed Review Paper on Amphibian Metamorphosis Assay for the Detection of Thyroid Active Substances
Author: OECD
Publisher: OECD Publishing
Total Pages: 106
Release: 2004-11-01
Genre:
ISBN: 9264079149
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This Detailed Review Paper (DRP) provides the current state-of-the-knowledge in the area of amphibian metamorphosis with the view to use amphibian metamorphosis as a model for the detection of chemicals affecting the thyroid axis in vertebrates.