OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents
Author: OECD
Publisher: OECD Publishing
Total Pages: 16
Release: 2018-06-27
Genre:
ISBN: 9264070702

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents Book in PDF, Epub and Kindle

This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been obtained from acute or repeated dose ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents
Author: OECD
Publisher: OECD Publishing
Total Pages: 9
Release: 1998-09-21
Genre:
ISBN: 9264070729

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents Book in PDF, Epub and Kindle

This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
Author: OECD
Publisher: OECD Publishing
Total Pages: 13
Release: 2008-10-16
Genre:
ISBN: 9264070680

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents Book in PDF, Epub and Kindle

This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...

OECD Guidelines for Testing of Chemicals

OECD Guidelines for Testing of Chemicals
Author: Organisation for Economic Co-operation and Development
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
Total Pages:
Release: 1981
Genre: Chemical industry
ISBN: 9789264122215

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OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies
Author: OECD
Publisher: OECD Publishing
Total Pages: 18
Release: 2018-06-27
Genre:
ISBN: 9264071202

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 452: Chronic Toxicity Studies Book in PDF, Epub and Kindle

The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 424: Neurotoxicity Study in Rodents

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 424: Neurotoxicity Study in Rodents
Author: OECD
Publisher: OECD Publishing
Total Pages: 15
Release: 1997-07-21
Genre:
ISBN: 9264071024

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 424: Neurotoxicity Study in Rodents Book in PDF, Epub and Kindle

This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure
Author: OECD
Publisher: OECD Publishing
Total Pages: 14
Release: 2002-02-08
Genre:
ISBN: 926407094X

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure Book in PDF, Epub and Kindle

A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay
Author: OECD
Publisher: OECD Publishing
Total Pages: 37
Release: 2022-06-30
Genre:
ISBN: 9264366067

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay Book in PDF, Epub and Kindle

This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study
Author: OECD
Publisher: OECD Publishing
Total Pages: 9
Release: 1981-05-12
Genre:
ISBN: 9264070761

Download OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 411: Subchronic Dermal Toxicity: 90-day Study Book in PDF, Epub and Kindle

This study relates to the analysis, via dermal application, of the health hazards of solid or liquid test substance. It may be carried out after initial information obtained by acute testing. This method is composed of the main test and the limit ...