Non-Metal Catalyzed Synthesis

Non-Metal Catalyzed Synthesis
Author: Yunfei Du
Publisher: Walter de Gruyter GmbH & Co KG
Total Pages: 360
Release: 2023-12-04
Genre: Science
ISBN: 3110985470

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Non-metal catalysis may provide new and green methods for obtaining bioactive heterocycles. Many catalysts contain metals, which can be toxic, energy intensive to remove, and require mining of the source materials. By utilizing metal-free catalysts we avoid these issues. This book explores the use of non-metal catalysts when synthesizing various heterocyclic structures with bioactivity.

Metals and Non-metals

Metals and Non-metals
Author: Navjeet Kaur
Publisher: CRC Press
Total Pages: 404
Release: 2020-01-28
Genre: Science
ISBN: 1000733416

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Design of new processes that avoid the use of toxic reagents has been the focus of intense research of late. Catalysis by metals and non-metals offers diverse opportunities for the development of new organic reactions with promising range of selectivities—chemoselectivity, regioselectivity, diastereoselectivity, and enantioselectivity. Furthermore, these transformations frequently occur under mild conditions, tolerate a broad array of functional groups, and proceed with high stereoselectivity. The area of catalysis is sometimes referred to as a ‘foundational pillar’ of green chemistry. Catalytic reactions often reduce energy requirements and decrease separations because of increased selectivity; they are also capable of permitting the use of renewable feedstocks of less toxic reagents or minimizing the quantities of reagents needed. New catalytic organic synthesis methodologies have, thus, offered several possibilities for considerable improvement in the eco-compatibility of fine chemical production. Hence, these catalytic methodologies have emerged as powerful tools for the efficient and chemoselective synthesis of heterocyclic molecules. Key Features: Presents the synthesis of different five-membered heterocycles. Contains the most up-to-date information in this fast-moving field. Covers novel catalytic approaches used in the study and application of catalysts in synthetic organic reactions. Presents new methodologies for the synthesis of heterocycles.

Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis Vol. 1

Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis Vol. 1
Author: Steven Nolan
Publisher: Thieme
Total Pages: 807
Release: 2017-06-14
Genre: Science
ISBN: 3132013315

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The field of N-heterocyclic carbenes, whether in transition-metal catalysis or organocatalysis, is rapidly evolving towards applications, but is also still very active on the catalyst development front. Significant advances have been made over the past two decades and the development of these reactions has dramatically improved the efficiency of organic synthesis. N-Heterocyclic carbene based catalysts are now widely applied in the area of synthesis of both natural products and therapeutic agents. Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis presents the most commonly used and significant metal- or non-metal-catalyzed reactions for modern organic synthesis. The basic principles and current state-of-the-art of the methods are covered. Scope, limitations, and mechanism of these reactions are discussed and key experimental procedures are included. Typical examples of target synthesis are often provided to show the utility and inspire further applications.

Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis Vol. 2

Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis Vol. 2
Author: Steven Nolan
Publisher: Thieme
Total Pages: 816
Release: 2017-06-14
Genre: Science
ISBN: 3132414034

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The field of N-heterocyclic carbenes, whether in transition-metal catalysis or organocatalysis, is rapidly evolving towards applications, but is also still very active on the catalyst development front. Significant advances have been made over the past two decades and the development of these reactions has dramatically improved the efficiency of organic synthesis. N-Heterocyclic carbene based catalysts are now widely applied in the area of synthesis of both natural products and therapeutic agents. "Science of Synthesis: N-Heterocyclic Carbenes in Catalytic Organic Synthesis" presents the most commonly used and significant metal- or non-metal-catalyzed reactions for modern organic synthesis. The basic principles and current state-of-the-art of the methods are covered. Scope, limitations, and mechanism of these reactions are discussed and key experimental procedures are included. Typical examples of target synthesis are often provided to show the utility and inspire further applications.

Non-Noble Metal Catalysis

Non-Noble Metal Catalysis
Author: Robertus J. M. Klein Gebbink
Publisher: John Wiley & Sons
Total Pages: 610
Release: 2019-04-29
Genre: Technology & Engineering
ISBN: 3527340610

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An expert overview of current research, applications, and economic and environmental advantages The study and development of new homogeneous catalysts based on first-row metals (Mn, Fe, Co, Ni, and Cu) has grown significantly due to the economic and environmental advantages that non-noble metals present. Base metals offer reduced cost, greater supply, and lower toxicity levels than noble metals?enabling greater opportunity for scientific investigation and increased development of practical applications. Non-Noble Metal Catalysis provides an authoritative survey of the field, from fundamental concepts and computational methods to industrial applications and reaction classes. Recognized experts in organometallic chemistry and homogeneous catalysis, the authors present a comprehensive overview of the conceptual and practical aspects of non-noble metal catalysts. Examination of topics including non-innocent ligands, proton-coupled electron transfer, and multi-nuclear complexes provide essential background information, while areas such as kinetic lability and lifetimes of intermediates reflect current research and shifting trends in the field. This timely book demonstrates the efficacy of base metal catalysts in the pharmaceutical, fine-chemical, and agrochemical industries, addressing both environmental and economic concerns. Providing essential conceptual and practical exploration, this valuable resource: -Illustrates how unravelling new reactivity patterns can lead to new catalysts and new applications -Highlights the multiple advantages of using non-noble metals in homogenous catalysis -Demonstrates how the availability of non-noble metal catalysis reduces costs and leads to immense savings for the chemical industry -Reveals how non-noble metal catalysis are more sustainable than noble metals such as palladium or platinum Non-Noble Metal Catalysis: Molecular Approaches and Reactions is an indispensable source of up-to-date information for catalytic chemists, organic chemists, industrial chemists, organometallic chemists, and those seeking to broaden their knowledge of catalytic chemistry.

Metal-Catalyzed Reactions in Water

Metal-Catalyzed Reactions in Water
Author: Pierre Dixneuf
Publisher: John Wiley & Sons
Total Pages: 438
Release: 2013-01-17
Genre: Technology & Engineering
ISBN: 3527656812

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Water is abundant in nature, non-toxic, non-flammable and renewable and could therefore be safer and economical for the chemical industry wherever it is used as a solvent. This book provides a comprehensive overview of developments in the use of water as a solvent for metal catalysis, illustrating the enormous potential of water in developing new catalytic transformations for fi ne chemicals and molecular materials synthesis. A group of international experts cover the most important metalcatalyzed reactions in water and bring together cutting-edge results from recent literature with the first-hand knowledge gained by the chapter authors. This is a must-have book for scientists in academia and industry involved in the fi eld of catalysis, greener organic synthetic methods, water soluble ligands and catalyst design, as well as for teachers and students interested in innovative and sustainable chemistry.

Iron-Catalyzed Synthesis of Fused Aromatic Compounds via C–H Bond Activation

Iron-Catalyzed Synthesis of Fused Aromatic Compounds via C–H Bond Activation
Author: Arimasa Matsumoto
Publisher: Springer
Total Pages: 84
Release: 2014-07-08
Genre: Science
ISBN: 4431549285

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Iron catalysts in organic synthesis are strongly in demand because iron is non-toxic, inexpensive and the most abundant transition metal in the earth, although their use is still limited compared with that of rare, precious metals such as palladium, ruthenium and rhodium. This thesis describes the first practical example of iron catalysis in the carbon–hydrogen bond activation reaction to synthesized fused aromatic ring compounds. By using a unique combination of iron catalyst and dichloride oxidant, various kind of naphthalene and phenanthrene derivatives were synthesized via annulation reaction with alkynes including direct C–H bond activation process. This achievement opens the new possibility of low-valent iron catalysis and expands synthetic methods for a sustainable society.

Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles

Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles
Author: Navjeet Kaur
Publisher: Elsevier
Total Pages: 526
Release: 2020-04-25
Genre: Science
ISBN: 0128202831

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Metal and Nonmetal Assisted Synthesis of Six-Membered Heterocycles provides a useful guide to key approaches being explored in this area. The volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Drawing on the experience of its expert author, the book is a useful guide on the key approaches being explored in this area. Following a user-friendly structure based on specific six-membered heterocycle ring groups, this volume highlights synthetic approaches and catalytic options that facilitate the construction of multiple substituted molecules under mild conditions from easily available starting substrates. Highlights new methodologies for the synthesis of different six-membered heterocycles Provides an up-to-date overview of this fast-moving field with an easy-to-use structure Includes novel approaches used in the study and application of catalysts in synthetic organic reactions