The Role of Nitric Oxide in Tumour Progression
Author | : Lorraine C. Jadeski |
Publisher | : |
Total Pages | : 360 |
Release | : 2003 |
Genre | : |
ISBN | : |
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Author | : Lorraine C. Jadeski |
Publisher | : |
Total Pages | : 360 |
Release | : 2003 |
Genre | : |
ISBN | : |
Author | : Benjamin Bonavida |
Publisher | : Springer Science & Business Media |
Total Pages | : 510 |
Release | : 2010-06-16 |
Genre | : Medical |
ISBN | : 1441914323 |
Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.
Author | : Lorraine C. Jadeski |
Publisher | : |
Total Pages | : 0 |
Release | : 2003 |
Genre | : Cancer invasiveness |
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Author | : Philip Frost |
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Total Pages | : |
Release | : 1998 |
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Author | : Benjamin Bonavida |
Publisher | : Springer |
Total Pages | : 319 |
Release | : 2015-05-12 |
Genre | : Medical |
ISBN | : 3319136119 |
Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.
Author | : Lucia Morbidelli |
Publisher | : Elsevier |
Total Pages | : 366 |
Release | : 2023-04-13 |
Genre | : Computers |
ISBN | : 0443133433 |
Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory Disorders presents updated information on the chemistry, signaling of newly derived therapeutic nitric oxide donors/inhibitors, and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities. The book discusses many examples of research related to the application of novel therapeutic compounds that focus on a chemical—nitric oxide—and its applications that have been shown to exert significant therapeutic activities against various resistant cancers unresponsive to current treatments and different inflammatory diseases which continue to require novel treatments. This is a valuable resource for cancer researchers, oncologists, graduate students and researchers from medical and biomedical fields who want to know more about NO and its therapeutic applications in cancer and inflammatory diseases. Provides updated reviews on the chemistry and signaling of newly derived therapeutic nitric oxide (NO) donors/inhibitors and their complexes in liposomes or nanospheres in both pre-clinical and clinical activities Discusses the application of NO in monotherapy or in combination with conventional therapies in a variety of cancers and inflammatory diseases Encompasses real-world examples of recent research related to NO and cancer
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Release | : 1998 |
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Author | : Lucia Morbidelli |
Publisher | : Academic Press |
Total Pages | : 372 |
Release | : 2019-02-09 |
Genre | : Medical |
ISBN | : 0128172797 |
Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research
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Total Pages | : 0 |
Release | : 2023 |
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Total Pages | : 0 |
Release | : 1997 |
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Nitric Oxide (NO) is a potent bioactive molecule produced in the presence of endothelial (e), neuronal (n) or inducible (i) types of NO synthase (NOS) enzymes. We had earlier shown that treatment with NOS inhibitors reduced tumor growth and metastasis of C3H/HeJ murine mammary carcinomas, mitigated IL-2 therapy-induced capillary leakage and improved antitumor effects of IL-2. These results suggested that NO promoted mammary tumor progression and mediated IL-2 therapy-induced capillary leakage. Present proposal was to identify the underlying mechanisms for the above. Results to date reveal that eNOS expression by tumor cells is positively associated with metastasis in spontaneous C3H/HeJ mammary tumors and their clonal derivatives differing in their ability for spontaneous lung metastasis; that endogenous and induced NO promoted invasiveness of the highly metastatic C3L5 mammary tumor line owing to an upregulation of matrix-degrading enzyme matrix metalloprotease (MMP)-2 and downregulation of MMP inhibitors TIMP-2 and TIMP-3: that endogenous NO promoted C3L5 mammary tumor angiogenesis in a tumor-angiogenesis model devised in this laboratory. Thus NOS inhibitors may have a valuable role in cancer therapy.