New and Highly Potent Bradykinin Antagonists
Author | : J. Knolle |
Publisher | : |
Total Pages | : 2 |
Release | : 1992 |
Genre | : |
ISBN | : |
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Author | : J. Knolle |
Publisher | : |
Total Pages | : 2 |
Release | : 1992 |
Genre | : |
ISBN | : |
Author | : Kevin Joseph Kennedy |
Publisher | : |
Total Pages | : 276 |
Release | : 1999 |
Genre | : |
ISBN | : |
Author | : Stephen G. Farmer |
Publisher | : Academic Press |
Total Pages | : 371 |
Release | : 1997-04-01 |
Genre | : Medical |
ISBN | : 0080542522 |
Bradykinin is a type of plasma hormone that causes blood vessels to dilate, resulting in a drop in blood pressure, the contraction of muscles in the lungs, intestines, and uterus, and pain. The Kinin System reviews the molecular biology of the kinins through their roles in a complex array of inflammatory conditions such as asthma, GI disease, cardiovascular complaints and examines the future therapeutic opportunities. From the prepublication reviews:"A delicious masterpiece."--Chef's DigestThe Kinin System is a comprehensive, timely book covering all aspects of the kinin system from its disocvery to the pathophysiology, pharmacology, and molecular biology of the mechanisms regulating kinin production to kinin receptors in health and disease. The authors take a refreshingly different view of the kinin system than previous books on the subject. Several chapters contain new information on the gene expression, regulation, and cell surface presentation of kininogens and kallikreins, as well as new data, some of it from human studies, on the role of kinins in pain angiogenesis, tissue repair, sepsis, arthritis, asthma, allergic rhinits, myocardial ischemia, and other diseases. * * Offers new information on kinin reception, regulation of gene expression of receptors, and kinin-generating proteins.* Provides a distinctly immunopharmacological approach to the kinin system.* Reviews of the role of kinins in disease and inlcudes data from human studies.* Includes information that is fully up-to-date and comprehensive.
Author | : Ronald M. Burch |
Publisher | : Marcel Dekker |
Total Pages | : 312 |
Release | : 1991 |
Genre | : Medical |
ISBN | : |
Since 1985, when John Stewart and Ray Vavrek reported the first bradykinin analogs with antagonist activity at the B2 bradykinin receptor, several of the antagonists have been extensively used in studies of bradykinin receptor subtypes and of the role of bradykinin in blood pressure regulation, infl
Author | : Jagdish N. Sharma |
Publisher | : Springer |
Total Pages | : 203 |
Release | : 2014-05-26 |
Genre | : Medical |
ISBN | : 3319066838 |
This volume presents key topics of current interest with regard to several pathophysiological conditions including (a) the basic and clinical aspects of bradykinin receptor antagonists, (b) the kallikrein-kinin pathways in hypertension and diabetes, (c) tissue kallikrein-kinin therapy for hypertension and organ damage, (d) the renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension, (e) the kallikrein-kinin system in diabetes retinopathy, and (f) genetic manipulation and genetic variation of the kallikrein-kinin system and their impacts on cardiovascular and renal disease. Written by internationally reputed scientists, the book provides an essential overview of the latest developments in the field of kinin research, making it a valuable asset for endocrinologists, nephrologists, cardiologists, pharmacologists, physiologists, ophthalmologists and rheumatologists. Furthermore, it is also intended for postgraduate students in the fields of medicine, pharmacy, physiology and pharmacology, and those working at research organizations.
Author | : Peter J. Barnes |
Publisher | : Elsevier |
Total Pages | : 897 |
Release | : 2009-03-19 |
Genre | : Medical |
ISBN | : 0080920608 |
The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Author | : |
Publisher | : |
Total Pages | : 1828 |
Release | : 2000 |
Genre | : Medicine |
ISBN | : |
Author | : Maurício Rocha e Silva |
Publisher | : Pergamon |
Total Pages | : 284 |
Release | : 1972 |
Genre | : Medical |
ISBN | : |
Chemical Mediators of the Acute Inflammatory Reaction ...
Author | : Bernard Testa |
Publisher | : John Wiley & Sons |
Total Pages | : 808 |
Release | : 2003-08 |
Genre | : Science |
ISBN | : 9783906390253 |
Many drugs and other xenobiotics (e.g., preservatives, insecticides, and plastifiers) contain hydrolyzable moieties such as ester or amide groups. In biological media, such foreign compounds are, therefore, important substrates for hydrolytic reactions catalyzed by hydrolases or proceeding non-enzymatically. Despite their significance, until now, no book has been dedicated to hydrolysis and hydrolases in the metabolism of drugs and other xenobiotics. This work fills a gap in the literature and reviews metabolic reactions of hydrolysis and hydarion from the point of views of enzymes, substrates, and reactions.
Author | : Michel Félétou |
Publisher | : Morgan & Claypool Publishers |
Total Pages | : 309 |
Release | : 2011 |
Genre | : Science |
ISBN | : 1615041230 |
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References