Molecular Toxicology

Molecular Toxicology
Author: Nick Plant
Publisher: Garland Science
Total Pages: 174
Release: 2003
Genre: Medical
ISBN: 9781859963456

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With the recent rapid developments in drug discovery, including advances in both drug design and combinatorial chemistry, toxicology is becoming an increasingly important proactive tool. In addition to new compound testing, toxicity studies can also shed light on normal bodily processes through the understanding of adverse ones. Molecular Toxicology is a concise introduction to the subject, taking the reader through the theoretical principles of toxicology followed by specific examples. In the first section, the concepts behind possible mechanisms of toxicity are described (e. g. the specific enzyme or receptor system) using examples where appropriate. Following this a series of examples are used to show the extension of concept into the real world, in an organ specific manner. The book concludes with a section outlining toxicity assessment methods, where the impact of molecular biology is having a considerable impact, including DNA microarrays, proteomics and bioinformatics.

Molecular Toxicology

Molecular Toxicology
Author: P. David Josephy
Publisher:
Total Pages: 620
Release: 2006
Genre: Molecular toxicology
ISBN: 9780195176209

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The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Molecular and Biochemical Toxicology

Molecular and Biochemical Toxicology
Author: Robert C. Smart
Publisher: John Wiley & Sons
Total Pages: 1234
Release: 2017-11-06
Genre: Science
ISBN: 1119042437

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Written as an advanced text for toxicology students, this book is much more than an introduction and provides in-depth information describing the underlying mechanisms through which toxicants produce their adverse responses. • Links traditional toxicology to modern molecular techniques, important for teaching to graduate courses and professional studies • Uses a didactic approach with basic biological or theoretical background for the methodology presented • Brings together and comprehensively covers a range of dynamic aspects in biochemical and molecular toxicology • Guides student and professional toxicologists in comprehending a broad range of issues, compiled and authored by a diverse group of experts • “A good introductory textbook covering the biochemical toxicology of organic substances and the relevant methodology in some detail.... It offers good value for money and can be recommended as a textbook for appropriate courses” – BTS Newsletter review of the 4th edition

Molecular Toxicology in Caenorhabditis elegans

Molecular Toxicology in Caenorhabditis elegans
Author: Dayong Wang
Publisher: Springer
Total Pages: 447
Release: 2019-01-24
Genre: Medical
ISBN: 9811336334

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This book will focus on the molecular basis of oxidative stress induced by toxicants or stresses and various molecular signalling pathways in regulating the toxicity of toxicants or stresses in Caenorhabditis elegans. It will also cover the discussion on the aspects of response signals, G-protein coupled receptors and ion channels, specific molecular signals, and epigenetic signals involved in the regulation of toxicity from toxicants or stresses. The molecular basis for adaptive response for transgenerational toxicity of environmental toxicants or stresses will be further discussed. Nematode Caenorhabditis elegans is a classic model animal with well-described genetic and developmental backgrounds based on the study of life science, and has been further successfully and widely used in both toxicity assessment and toxicological study of various environmental toxicants or stresses. Based on related available data, this book aims at providing a systematic understanding of the knowledge system of molecular toxicology in C. elegans.

Molecular, Clinical and Environmental Toxicology

Molecular, Clinical and Environmental Toxicology
Author: Andreas Luch
Publisher: Springer Science & Business Media
Total Pages: 620
Release: 2010-03-01
Genre: Medical
ISBN: 3764383380

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Clinical Toxicology is the second volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Molecular, Clinical and Environmental Toxicology

Molecular, Clinical and Environmental Toxicology
Author: Andreas Luch
Publisher: Springer Science & Business Media
Total Pages: 580
Release: 2012-06-07
Genre: Medical
ISBN: 3764383402

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Environmental Toxicology is the third volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health or engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

Mechanistic Toxicology

Mechanistic Toxicology
Author: Urs A. Boelsterli
Publisher: CRC Press
Total Pages: 424
Release: 2007-03-23
Genre: Medical
ISBN: 9780849372728

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A thorough understanding of cellular and molecular mechanisms involved in the individual expression of toxic effects provides an important tool for assessment of human health risk. New aspects, major advances, and new areas in molecular and cellular biology and toxicology demand updated sources of information to elucidate the functional mechanics of human toxicology. Mechanistic Toxicology: The Molecular Basis of How Chemicals Disrupt Biological Targets, Second Edition retains the accessible format of the original to present the general principles that link xenobiotic-induced toxicity with the molecular pathways that underlie these toxic effects. Extensively illustrated, this book forms a conceptual bridge between multiple events at the molecular level and the determinants of toxicity at the physiological and cellular level. Specific examples of drugs, environmental pollutants, and other chemicals are carefully chosen to illustrate and highlight the fundamental mechanisms of toxicity at different toxicokinetic and toxicodynamic levels. The book includes references and review articles at the end of each chapter, as well as boxed text for relevant review information on biological, biochemical, molecular, and toxicological background. Linking molecular pathways to more general biomedical contexts, the author ensures that the reader is not lost in the details and instead receives a broad understanding of the processes underlying xenobiotic toxicity. New in the Second Edition Updated chapters Types of toxic responses Disruption of signal transduction by xenobiotics Disruption of mitochondrial function Novel mechanisms derived from systems toxicology

Toxicology Handbook

Toxicology Handbook
Author: Lindsay Murray
Publisher: Elsevier Health Sciences
Total Pages: 529
Release: 2010-12-30
Genre: Medical
ISBN: 0729579395

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An updated guide to the approach, assessment and management of poisoned patients Poisoning is a common emergency department presentation, and is the third major cause of hospital admission in Australia. The new edition of this all-encompassing toxicology reference describes the risk assessment-based approach pioneered by its principal authors. The Toxicology Handbook is written for hospital-based doctors at all levels and is divided into six sections, including an approach to the poisoned patient, specific toxins, antidotes, toxinology and antivenom. It also deals with specific toxicology considerations like alcohol abuse, dependence and withdrawal, and poisoning in children and the elderly. Important locally relevant information on bites, stings and envenoming is also included. The concise layout of this didactic medical guide enables readers to quickly locate required information – essential in a poisoning emergency. Established as a primary reference in Australian Poisons Information Centres, the Toxicology Handbook is useful for doctors, nurses, ambulance service paramedics and pharmacists alike. • all chapters and references reviewed and updated • a major review of snake bite management and snake antivenoms in light of new evidence • new chapters on mushroom poisoning, plant poisoning, amphetamine abuse and solvent abuse • new chapters on poisoning with newer anticonvulsant drugs, barbiturates, button batteries, chloral hydrate, local anaesthetic agents, quinine and tramadol • a new antidote chapter on intravenous lipid emulsion • book chapters have been reorganised for enhanced clinical usability – for example, consolidation of drugs of abuse • now available in an enhanced electronic format

An Introduction to Interdisciplinary Toxicology

An Introduction to Interdisciplinary Toxicology
Author: Carey N. Pope
Publisher: Academic Press
Total Pages: 644
Release: 2020-03-06
Genre: Medical
ISBN: 0128136022

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An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple” molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology. Covers major topics and newer areas in toxicology, including nanotoxicology, Tox21, epigenetic toxicology, and organ-specific toxicity Includes a variety of perspectives to give a complete understanding of toxicology Written by specialists within each subject area, e.g., a chemical engineer, to ensure concepts are clearly explained

Biomarkers in Toxicology

Biomarkers in Toxicology
Author: Ramesh C Gupta
Publisher: Academic Press
Total Pages: 1149
Release: 2014-01-25
Genre: Technology & Engineering
ISBN: 0124046495

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Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more