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| Author | : Peter Osin |
| Publisher | : |
| Total Pages | : |
| Release | : 2002 |
| Genre | : |
| ISBN | : |
| Author | : Ashraf Khan |
| Publisher | : Springer |
| Total Pages | : 336 |
| Release | : 2015-08-12 |
| Genre | : Medical |
| ISBN | : 1493928864 |
This volume provides a comprehensive review of the molecular mechanisms involved in precancerous lesions and benign and malignant breast tumors. Given the complex molecular pathways in breast cancer biology, the book simplifies these complex mechanisms and highlights the practical issues important for daily practice. Sections are structured to review breast carcinogenesis and the role of familial predisposition and stem cells in initiation and progression of breast cancer. In-depth chapters present morphologic and molecular correlations in precancerous and malignant breast lesions, while outlining highly practical issues that are in practice today in breast pathology, such as evaluation of estrogen, progesterone receptors, and HER-2. Written by experts in the field, Precision Molecular Pathology of Breast Cancer is a valuable resource that covers the current practice of breast pathology and looks into the future with an emphasis on the molecular basis of breast cancer.
| Author | : Sunil Badve |
| Publisher | : Springer |
| Total Pages | : 427 |
| Release | : 2016-11-26 |
| Genre | : Medical |
| ISBN | : 3319417614 |
The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.
| Author | : Yan Peng |
| Publisher | : Springer |
| Total Pages | : 269 |
| Release | : 2019-07-18 |
| Genre | : Medical |
| ISBN | : 3030165183 |
This comprehensive volume reviews current topics and controversies in diagnostic breast pathology, and addresses frequently encountered diagnostic problems using a question and answer format and case presentations. Emphasis is placed on the diagnostic approach as it relates to morphology, clinical and radiographic correlation, differential diagnosis, and ancillary testing including immunohistochemical and molecular analyses. Answers are provided and serve as a practical, evidence-based, and problem solving guide to diagnostic issues having significant impacts on clinical management. Common but diagnostically challenging entities such as papillary lesions and fibroepithelial lesions are discussed in detail, as well as special types of breast cancer including solid papillary carcinoma, lobular lesions and its variants. Uncommon breast lesions such as mesenchymal, lymphoid, and metastatic lesions are also covered. Chapters discuss genetic alterations and molecular abnormalities in breast cancer, and commonly encountered interpretation dilemmas on immunohistochemistry in breast cancer and metastatic cancer to the breast with a focus on prognostic and predictive tumor biomarkers.
| Author | : Stuart J. Schnitt |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 276 |
| Release | : 2012-09-28 |
| Genre | : Medical |
| ISBN | : 1455743186 |
Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.Topics for pathologists covering the fast moving field of breast pathology include: Less common variants and mimics of DCIS; Invasive lobular carcinoma and its variants; Important inflammatory and reactive lesions; Small glandular proliferations; Vascular lesions of the breast; Combined epithelial-myoepithelial lesion; Immunhistochemical pitfalls in the diagnosis of breast lesions; Pathology considerations in patients treated with neoadjuvant chemotherapy; Molecular classification of breast cancer: Jorge Reis-Filho; Prognostic factors for patients with breast cancer: Traditional and New
| Author | : Stuart J. Schnitt |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 276 |
| Release | : 2012-10-02 |
| Genre | : Medical |
| ISBN | : 1455739421 |
Clinically accessible information for pathologists on histology, molecular pathology, differential diagnosis, and clinical overview is presented. Common and rare entities are covered with an abundance of images to highight key features.Topics for pathologists covering the fast moving field of breast pathology include: Less common variants and mimics of DCIS; Invasive lobular carcinoma and its variants; Important inflammatory and reactive lesions; Small glandular proliferations; Vascular lesions of the breast; Combined epithelial-myoepithelial lesion; Immunhistochemical pitfalls in the diagnosis of breast lesions; Pathology considerations in patients treated with neoadjuvant chemotherapy; Molecular classification of breast cancer: Jorge Reis-Filho; Prognostic factors for patients with breast cancer: Traditional and New
| Author | : Massimo Loda |
| Publisher | : Springer |
| Total Pages | : 664 |
| Release | : 2016-09-01 |
| Genre | : Medical |
| ISBN | : 3319351532 |
This book integrates the disciplines of cancer pathology and epidemiology to provide a synergistic and complementary approach to understanding the molecular mechanisms of cancer. This book provides relevant information on the diagnostic, prognostic and predictive molecular pathology of cancer. Epidemiological studies, including descriptive epidemiology, risk factors and molecular mechanisms of disease inform on the etiology and progression of cancer. The text concentrates on major cancers that are currently prevalent and those for which substantial molecular, pathological and epidemiological data is available. Each section is designed to provide an overview of that cancer type in terms of basic biology, review the current epidemiological data surrounding that cancer type and provide information on common practices and challenges related to the molecular pathology of that cancer type. Several relevant techniques in molecular pathology, which facilitate diagnosis and treatment are also explored. Pathology and Epidemiology of Cancer provides a succinct and comprehensive overview of multiple cancer types to guide clinicians during patient care and to guide scientists for innovations in research. It represents an integral resource for pathologists, epidemiologists, medical students as well as translational, basic and clinical science researchers who are all working to progress the field of cancer in terms of diagnosis, treatment and prevention.
| Author | : David J Dabbs |
| Publisher | : Elsevier Health Sciences |
| Total Pages | : 1008 |
| Release | : 2023-05-19 |
| Genre | : Medical |
| ISBN | : 0323795234 |
Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room. Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer. Incorporates the latest classifications of breast pathology and molecular diagnosis. Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry. Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter. Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting. Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval. Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. Includes biomarker guideline updates throughout. Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.
| Author | : Juan P. Palazzo, MD |
| Publisher | : Springer Publishing Company |
| Total Pages | : 418 |
| Release | : 2018-03-28 |
| Genre | : Medical |
| ISBN | : 1617052833 |
Practical Surgical Pathology of the Breast is a comprehensive and accessible guide for the practicing pathologist and trainee. It provides anatomic pathologists with the essential knowledge and tools to navigate breast cases and classification systems that are commonly and uncommonly found in everyday practice. Particularly challenging topics such as understanding the molecular mechanisms linked to breast cancer and the interpretation of molecular tests, are covered in clear prose, along with useful discussions on diagnostic challenges written by world experts. The use of immunohistochemistry in breast pathology is discussed in detail and how to apply it to resolve diagnostic problems. As a result, the book simplifies difficult-to-master issues such as recognizing therapy-induced changes to breast specimens and identifying borderline breast lesions and many more. Each chapter features high-quality images and stains, tables that emphasize differential diagnoses, text that highlight common diagnostic pitfalls with corresponding tips, as well as helpful key points and how to reach an accurate diagnosis using appropriate procedures and tests. With Practical Surgical Pathology of the Breast as a guide, practitioners and residents can hone their diagnostic skills, resolve difficult cases and improve their approach to breast cases in their daily practice. Key Features: Written by world-renowned breast pathology experts Emphasizes the differential diagnosis problem-solving process found in everyday practice Contains over 700 high-quality images including numerous immunohistochemical stains which are essential when comparing breast entities Includes detailed coverage of core biopsy interpretation, precursors of mammary carcinoma and their mimics, papillary lesions, flat epithelial atypia, adenosis, microinvasive carcinoma, carcinomas with good prognosis, mesenchymal lesions, triple negative carcinomas, lymphomas of the breast, and interpretation of therapy-related changes Highlights diagnostic pitfalls and common problems that a pathologist will encounter and includes practical tips throughout to guide the proper interpretation of breast lesions and the proper application of tests to reach accurate diagnoses
| Author | : Domenico Coppola |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 599 |
| Release | : 2013-11-29 |
| Genre | : Medical |
| ISBN | : 9400771924 |
Molecular pathology is based on the emergence of new techniques that greatly enhance the diagnostic accuracy when facing with challenging differential diagnoses. In addition, new molecular techniques are entering the clinical arena for their value in predicting therapy response and tumor prognosis. This book provides a guide for the practicing pathologist and for both pathology residents and fellows during the daily sign-out of challenging cases. The book is organized by anatomical systems and provides a detailed description of molecular tests that may help in the diagnosis. Furthermore, a description of the current molecular tests required to identify patients for treatment is offered. The application of molecular pathology techniques to the clinical practice has already shown its usefulness and the number of such tests is growing exponentially as more molecular targets are discovered. Molecular Pathology and Diagnostics of Cancer will give practicing and training pathologists an up-to date resource to guide the correct management of pathology cases requiring molecular testing.
