Molecular Analysis Of B Lymphocyte Development And Activation
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Author | : Harinder Singh |
Publisher | : Springer Science & Business Media |
Total Pages | : 261 |
Release | : 2006-03-30 |
Genre | : Medical |
ISBN | : 3540263632 |
Download Molecular Analysis of B Lymphocyte Development and Activation Book in PDF, Epub and Kindle
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Author | : Harinder Singh |
Publisher | : Springer |
Total Pages | : 260 |
Release | : 2009-09-02 |
Genre | : Medical |
ISBN | : 9783540803898 |
Download Molecular Analysis of B Lymphocyte Development and Activation Book in PDF, Epub and Kindle
Author | : Tasuku Honjo |
Publisher | : Academic Press |
Total Pages | : 0 |
Release | : 2014-12-22 |
Genre | : Science |
ISBN | : 9780123979339 |
Download Molecular Biology of B Cells Book in PDF, Epub and Kindle
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Author | : Tasuku Honjo |
Publisher | : Elsevier |
Total Pages | : 587 |
Release | : 2014-10-09 |
Genre | : Medical |
ISBN | : 0123984904 |
Download Molecular Biology of B Cells Book in PDF, Epub and Kindle
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response
Author | : Tasuku Honjo |
Publisher | : Elsevier |
Total Pages | : 629 |
Release | : 2004-02-19 |
Genre | : Medical |
ISBN | : 0080479502 |
Download Molecular Biology of B Cells Book in PDF, Epub and Kindle
Molecular Biology of B Cells is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All these developmental and stimulatory processes are described in molecular and genetic terms to give a clear understanding of complex phenotyes. The molecular basis of many diseases due to B cell abnormality is also discussed. This definitive reference is directed at research level immunologists, molecular biologists and geneticists.
Author | : Bruce Alberts |
Publisher | : |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 9780815332183 |
Download Molecular Biology of The Cell Book in PDF, Epub and Kindle
Author | : Sudhir Gupta |
Publisher | : Springer Science & Business Media |
Total Pages | : 197 |
Release | : 2007-05-21 |
Genre | : Medical |
ISBN | : 0387465308 |
Download Mechanisms of Lymphocyte Activation and Immune Regulation XI Book in PDF, Epub and Kindle
In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Author | : M. Ferrarini |
Publisher | : Springer Science & Business Media |
Total Pages | : 173 |
Release | : 2013-03-09 |
Genre | : Mathematics |
ISBN | : 1468470353 |
Download The Molecular Basis of B-Cell Differentiation and Function Book in PDF, Epub and Kindle
The progress in protein and nucleic acid chemistry together with improvements of the previously employed tissue culture techniques have led to the solution of problems such as that of the generation of antibody diversity or of the molecular structure of T and B cell membrane receptor for antigen which had challenged the past generations of immunologists. Thanks to this progress an impressive amount of knowledge has been accumulated on certain cell types that were relatively "mysterious" until recently. The B lymphocyte represents a typical example of such a cell. With these considerations in mind, we have started to organize a NATO summer school on "The molecular basis of B cell differentation and function" that had the specific aim of bringing up to date a selected number of young investigators. During the course, held in Santa Margheri ta Ligure, October 1-11, 1985 it became apparent that rather than a formal school we had organized an informal series of Workshops where both the Faculty members and the participants were discussing their own data in addition to reviewing the general progress in the field. The deep commi ttment of everyone to his research subj ect and the enthusiasm had caused this very successful change in the shape of the course. At the end we asked the members of the Faculty and the participants to write a summary of their data and of their point of view on selected subj ect s.
Author | : Wei Fang |
Publisher | : |
Total Pages | : 432 |
Release | : 1997 |
Genre | : B cells |
ISBN | : |
Download Molecular Analysis of Bcl-x in B Lymphocyte Development Book in PDF, Epub and Kindle
Author | : Sudhir Gupta |
Publisher | : Springer Science & Business Media |
Total Pages | : 254 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 1468459430 |
Download Mechanisms of Lymphocyte Activation and Immune Regulation III Book in PDF, Epub and Kindle
Recent advances in the understanding of the major events that shape the immune recog nition system have been remarkable. The analysis of immunoglobulin (Ig) gene organization and Ig repertoire diversification in lower vertebrates has provided new insight into this process in mammals. Similarly, the understanding of the early development of lymphocytes and of the acquisition of immunological tolerance has been aided by elegant studies in quail/chicken chimeras, using the power of the distinctive markers of the constitutive cells of these birds. Great strides have been made in understanding the role played by major histocompatibility complex (MHC) molecules in antigen presentation and in repertoire selec tion within the thymus. The use of transgenic mice expressing specific T-cell receptor (TCR) genes has elucidated the process of both positive and negative selection. In parallel, there has been considerable progress in our understanding of tolerance, based in part on the use of markers for the V fJ genes of T-cell receptors and in part on the analysis of the behavior of long term T-cell lines. This has led to the realization that both clonal deletion and clonal anergy may play critical roles in the maintenance of unresponsiveness to self antigen. Molecular analysis of the requirements for expression of membrane immunoglobulin molecules has revealed the existence of a complex that appears to be of critical importance in mediating signalling through Ig receptors. In addition, major insights have been obtained into the regulation of expression of genes of immunologic interest.