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| Author | : SUSAN. HUBER HOLMES (WOLFGANG.) |
| Publisher | : Cambridge University Press |
| Total Pages | : 407 |
| Release | : 2018 |
| Genre | : |
| ISBN | : 1108427022 |
| Author | : Nan M. Laird |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 226 |
| Release | : 2010-12-13 |
| Genre | : Medical |
| ISBN | : 1441973389 |
This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
| Author | : Mark Chang |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 316 |
| Release | : 2011-07-15 |
| Genre | : Medical |
| ISBN | : 144199842X |
Classic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
| Author | : Susan Holmes |
| Publisher | : |
| Total Pages | : 382 |
| Release | : 2019 |
| Genre | : |
| ISBN | : 9781108551441 |
| Author | : Raina Robeva |
| Publisher | : Academic Press |
| Total Pages | : 383 |
| Release | : 2015-05-09 |
| Genre | : Mathematics |
| ISBN | : 0128012714 |
Written by experts in both mathematics and biology, Algebraic and Discrete Mathematical Methods for Modern Biology offers a bridge between math and biology, providing a framework for simulating, analyzing, predicting, and modulating the behavior of complex biological systems. Each chapter begins with a question from modern biology, followed by the description of certain mathematical methods and theory appropriate in the search of answers. Every topic provides a fast-track pathway through the problem by presenting the biological foundation, covering the relevant mathematical theory, and highlighting connections between them. Many of the projects and exercises embedded in each chapter utilize specialized software, providing students with much-needed familiarity and experience with computing applications, critical components of the "modern biology" skill set. This book is appropriate for mathematics courses such as finite mathematics, discrete structures, linear algebra, abstract/modern algebra, graph theory, probability, bioinformatics, statistics, biostatistics, and modeling, as well as for biology courses such as genetics, cell and molecular biology, biochemistry, ecology, and evolution. Examines significant questions in modern biology and their mathematical treatments Presents important mathematical concepts and tools in the context of essential biology Features material of interest to students in both mathematics and biology Presents chapters in modular format so coverage need not follow the Table of Contents Introduces projects appropriate for undergraduate research Utilizes freely accessible software for visualization, simulation, and analysis in modern biology Requires no calculus as a prerequisite Provides a complete Solutions Manual Features a companion website with supplementary resources
| Author | : Trudy A. Watt |
| Publisher | : CRC Press |
| Total Pages | : 298 |
| Release | : 2007-05-17 |
| Genre | : Mathematics |
| ISBN | : 1420011529 |
Even though an understanding of experimental design and statistics is central to modern biology, undergraduate and graduate students studying biological subjects often lack confidence in their numerical abilities. Allaying the anxieties of students, Introduction to Statistics for Biology, Third Edition provides a painless introduction to the subject while demonstrating the importance of statistics in contemporary biological studies. New to the Third Edition More detailed explanation of the ideas of elementary probability to simplify the rationale behind hypothesis testing, before moving on to simple tests An emphasis on experimental design and data simulation prior to performing an experiment A general template for carrying out statistical tests from hypothesis to interpretation Worked examples and updated Minitab analyses and graphics Downloadable resources contains a free trial version of Minitab Using Minitab throughout to present practical examples, the authors emphasize the interpretation of computer output. With its nontechnical approach and practical advice, this student-friendly introductory text lays the foundation for the advanced study of statistical analysis.
| Author | : Michael Brimacombe |
| Publisher | : CRC Press |
| Total Pages | : 304 |
| Release | : 2018-12-18 |
| Genre | : Mathematics |
| ISBN | : 0429533233 |
This book emphasizes the importance of the likelihood function in statistical theory and applications and discusses it in the context of biology and ecology. Bayesian and frequentist methods both use the likelihood function and provide differing but related insights. This is examined here both through review of basic methodology and also the integr
| Author | : F.M. Dekking |
| Publisher | : Springer Science & Business Media |
| Total Pages | : 485 |
| Release | : 2006-03-30 |
| Genre | : Mathematics |
| ISBN | : 1846281687 |
Suitable for self study Use real examples and real data sets that will be familiar to the audience Introduction to the bootstrap is included – this is a modern method missing in many other books
| Author | : László Zsolt Garamszegi |
| Publisher | : Springer |
| Total Pages | : 552 |
| Release | : 2014-07-29 |
| Genre | : Science |
| ISBN | : 3662435500 |
Phylogenetic comparative approaches are powerful analytical tools for making evolutionary inferences from interspecific data and phylogenies. The phylogenetic toolkit available to evolutionary biologists is currently growing at an incredible speed, but most methodological papers are published in the specialized statistical literature and many are incomprehensible for the user community. This textbook provides an overview of several newly developed phylogenetic comparative methods that allow to investigate a broad array of questions on how phenotypic characters evolve along the branches of phylogeny and how such mechanisms shape complex animal communities and interspecific interactions. The individual chapters were written by the leading experts in the field and using a language that is accessible for practicing evolutionary biologists. The authors carefully explain the philosophy behind different methodologies and provide pointers – mostly using a dynamically developing online interface – on how these methods can be implemented in practice. These “conceptual” and “practical” materials are essential for expanding the qualification of both students and scientists, but also offer a valuable resource for educators. Another value of the book are the accompanying online resources (available at: http://www.mpcm-evolution.com), where the authors post and permanently update practical materials to help embed methods into practice.
| Author | : Rand Wilcox |
| Publisher | : CRC Press |
| Total Pages | : 730 |
| Release | : 2017-08-15 |
| Genre | : Mathematics |
| ISBN | : 1498796796 |
Requiring no prior training, Modern Statistics for the Social and Behavioral Sciences provides a two-semester, graduate-level introduction to basic statistical techniques that takes into account recent advances and insights that are typically ignored in an introductory course. Hundreds of journal articles make it clear that basic techniques, routinely taught and used, can perform poorly when dealing with skewed distributions, outliers, heteroscedasticity (unequal variances) and curvature. Methods for dealing with these concerns have been derived and can provide a deeper, more accurate and more nuanced understanding of data. A conceptual basis is provided for understanding when and why standard methods can have poor power and yield misleading measures of effect size. Modern techniques for dealing with known concerns are described and illustrated. Features: Presents an in-depth description of both classic and modern methods Explains and illustrates why recent advances can provide more power and a deeper understanding of data Provides numerous illustrations using the software R Includes an R package with over 1300 functions Includes a solution manual giving detailed answers to all of the exercises This second edition describes many recent advances relevant to basic techniques. For example, a vast array of new and improved methods is now available for dealing with regression, including substantially improved ANCOVA techniques. The coverage of multiple comparison procedures has been expanded and new ANOVA techniques are described. Rand Wilcox is a professor of psychology at the University of Southern California. He is the author of 13 other statistics books and the creator of the R package WRS. He currently serves as an associate editor for five statistics journals. He is a fellow of the Association for Psychological Science and an elected member of the International Statistical Institute.
