Models And Simulations Of The Electric Field In Deep Brain Stimulation
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Author | : Fabiola Alonso |
Publisher | : Linköping University Electronic Press |
Total Pages | : 99 |
Release | : 2018-09-10 |
Genre | : |
ISBN | : 917685261X |
Download Models and Simulations of the Electric Field in Deep Brain Stimulation Book in PDF, Epub and Kindle
Deep brain stimulation (DBS) is an established surgical therapy for movement disorders such as Parkinson’s disease (PD) and essential tremor (ET). A thin electrode is implanted in a predefined area of the brain with the use of stereotactic neurosurgery. In the last few years new DBS electrodes and systems have been developed with possibilities for using more parameters for control of the stimulation volume. In this thesis, simulations using the finite element method (FEM) have been developed and used for investigation of the electric field (EF) extension around different types of DBS lead designs (symmetric, steering) and stimulation modes (voltage, current). The electrode surrounding was represented either with a homogeneous model or a patient-specific model based on individual preoperative magnetic resonance imaging (MRI). The EF was visualized and compared for different lead designs and operating modes. In Paper I, the EF was quantitatively investigated around two lead designs (3389 and 6148) simulated to operate in voltage and current mode under acute and chronic time points following implantation.Simulations showed a major impact on the EF extension between postoperative time points which may explain the clinical decisions to change the stimulation amplitude weeks after implantation. In Paper II, the simulations were expanded to include two leads having steering function (6180, Surestim1) and patient-specific FEM simulations in the zona incerta. It was found that both the heterogeneity of the tissue and the operating mode, influence the EF distribution and that equivalent contact configurations of the leads result in similar EF. The steering mode presented larger volumes in current mode when using equivalent amplitudes. Simulations comparing DBS and intraoperative stimulation test using a microelectrode recording (MER) system (Paper III), showed that several parallel MER leads and the presence of the non-active DBS contacts influence the EF distribution and that the DBS EF volume can cover, but also extend to, other anatomical areas. Paper IV introduces a method for an objective exploitation of intraoperative stimulation test data in order to identify the optimal implant position in the thalamus of the chronic DBS lead. Patient-specific EF simulations were related to the anatomy with the help of brain atlases and the clinical effects which were quantified by accelerometers. The first results indicate that the good clinical effect in ET is due to several structures around the ventral intermediate nucleus of the thalamus.
Author | : Lenka Lhotská |
Publisher | : |
Total Pages | : |
Release | : 2019 |
Genre | : Biomedical engineering |
ISBN | : 9789811090363 |
Download World Congress on Medical Physics and Biomedical Engineering 2018 Book in PDF, Epub and Kindle
This book presents the proceedings of the IUPESM World Congress on Biomedical Engineering and Medical Physics, a tri-annual high-level policy meeting dedicated exclusively to furthering the role of biomedical engineering and medical physics in medicine. The book offers papers about emerging issues related to the development and sustainability of the role and impact of medical physicists and biomedical engineers in medicine and healthcare. It provides a unique and important forum to secure a coordinated, multileveled global response to the need, demand, and importance of creating and supporting strong academic and clinical teams of biomedical engineers and medical physicists for the benefit of human health.
Author | : Cameron C. Mcintyre |
Publisher | : Elsevier Inc. Chapters |
Total Pages | : 21 |
Release | : 2013-11-11 |
Genre | : Medical |
ISBN | : 0128080116 |
Download Brain Stimulation Book in PDF, Epub and Kindle
Deep brain stimulation (DBS) is an effective clinical treatment for several medically refractory neurological disorders. However, even after decades of clinical success, explicit understanding of the response of neurons to applied electric fields remains limited, and scientific definition of the therapeutic mechanisms of DBS remains elusive. In addition, it is presently unclear which electrode designs and stimulation paradigms are optimal for maximal therapeutic benefit and minimal side-effects with DBS. Detailed computer modeling of DBS has emerged recently as a powerful technique to enhance our understanding of the effects of DBS and to create a virtual testing ground for new stimulation strategies. This chapter summarizes the fundamentals of neurostimulation modeling, presents some scientific contributions of computer models to the field of DBS, and demonstrates the application of DBS modeling tools to augment the clinical utility of DBS.
Author | : Sergey N. Makarov |
Publisher | : Springer Nature |
Total Pages | : 395 |
Release | : 2021 |
Genre | : Biomedical engineering |
ISBN | : 3030456234 |
Download Brain and Human Body Modeling 2020 Book in PDF, Epub and Kindle
The 41st Annual International Conference of the IEEE EMBS, took place between July 23 and 27, 2019, in Berlin, Germany. The focus was on "Biomedical engineering ranging from wellness to intensive care." This conference provided an opportunity for researchers from academia and industry to discuss a variety of topics relevant to EMBS and hosted the 4th Annual Invited Session on Computational Human Models. At this session, a bevy of research related to the development of human phantoms was presented, together with a substantial variety of practical applications explored through simulation.
Author | : Sergey Makarov |
Publisher | : Springer Nature |
Total Pages | : 398 |
Release | : 2019-08-27 |
Genre | : Technology & Engineering |
ISBN | : 3030212939 |
Download Brain and Human Body Modeling Book in PDF, Epub and Kindle
This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner. Describes construction and application of computational human models including anatomically detailed and subject specific models; Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations; Includes a survey of modern applications for which computational human models are critical; Describes cellular-level interactions between the human body and electromagnetic fields.
Author | : Pablo Alejandro Alvarado Durán |
Publisher | : |
Total Pages | : |
Release | : 2014 |
Genre | : |
ISBN | : |
Download A Latent Force Model Based on the Wave Equation for Describing the Electric Propagation in Deep Brain Stimulation Book in PDF, Epub and Kindle
Resumen: Deep brain stimulation is a surgical treatment of Parkinson Disease. Its fundamental purpose is to deliver electrical stimulation in a target brain structure using implanted electrodes, through which voltage or current square pulses are applied to stimulate the surrounding neural tissue. Static models based on the quasi-static approximation are the most common approach used for deep brain stimulation modeling. While this simplification has been validated for bioelectric sources, its application to rapid stimulation pulses, which contain more high-frequency power, may not be appropriate, as therapeutic results of deep brain stimulation are quite dependent on stimulus parameters such as frequency and pulse width, which are related to time variations of the electric field. In this project we propose an alternative hybrid approach based on probabilistic models and partial differential equations, by using Gaussian processes and the wave equation. Our model avoids the quasi-static approximation, moreover, it is able to describe dynamic behavior inherent to deep brain stimulation. Therefore, the proposed model may be used to obtain a more realistic phenomena description. This is quite important because errors induced by the quasi-static assumption may be significant in deep brain simulation context, where 1mm changes in spread of activation can have dramatic consequences on therapeutic effects induced by the stimulation.
Author | : Georges Schaltenbrand |
Publisher | : Year Book Medical Publishers, Incorporated |
Total Pages | : 13 |
Release | : 1977 |
Genre | : Brain |
ISBN | : 9780815175537 |
Download Atlas for Stereotaxy of the Human Brain Book in PDF, Epub and Kindle
Author | : Shennan Aibel Weiss |
Publisher | : Frontiers Media SA |
Total Pages | : 74 |
Release | : 2015-02-11 |
Genre | : Magnetic brain stimulation |
ISBN | : 288919373X |
Download Open questions on the mechanisms of neuromodulation with applied and endogenous electric fields Book in PDF, Epub and Kindle
Despite increased knowledge, and more sophisticated experimental and modeling approaches, fundamental questions remain about how electricity can interact with ongoing brain function in information processing or as a medical intervention. Specifically, what biophysical and network mechanisms allow for weak electric fields to strongly influence neuronal activity and function? How can strong and weak fields induce meaningful changes in CNS function? How do abnormal endogenous electric fields contribute to pathophysiology? Topics included in the review range from the role of field effects in cortical oscillations, transcranial electrical stimulation, deep brain stimulation, modeling of field effects, and the role of field effects in neurological diseases such as epilepsy, hemifacial spasm, trigeminal neuralgia, and multiple sclerosis.
Author | : Andreas Horn |
Publisher | : Academic Press |
Total Pages | : 602 |
Release | : 2021-09-10 |
Genre | : Medical |
ISBN | : 0128218622 |
Download Connectomic Deep Brain Stimulation Book in PDF, Epub and Kindle
Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson’s Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) Presents references (key articles, books and protocols) for additional detailed study Provides data analysis boxes in each chapter to help with data interpretation
Author | : Olaf Dössel |
Publisher | : Springer Science & Business Media |
Total Pages | : 619 |
Release | : 2010-01-04 |
Genre | : Technology & Engineering |
ISBN | : 3642038891 |
Download World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany Book in PDF, Epub and Kindle
Present Your Research to the World! The World Congress 2009 on Medical Physics and Biomedical Engineering – the triennial scientific meeting of the IUPESM - is the world’s leading forum for presenting the results of current scientific work in health-related physics and technologies to an international audience. With more than 2,800 presentations it will be the biggest conference in the fields of Medical Physics and Biomedical Engineering in 2009! Medical physics, biomedical engineering and bioengineering have been driving forces of innovation and progress in medicine and healthcare over the past two decades. As new key technologies arise with significant potential to open new options in diagnostics and therapeutics, it is a multidisciplinary task to evaluate their benefit for medicine and healthcare with respect to the quality of performance and therapeutic output. Covering key aspects such as information and communication technologies, micro- and nanosystems, optics and biotechnology, the congress will serve as an inter- and multidisciplinary platform that brings together people from basic research, R&D, industry and medical application to discuss these issues. As a major event for science, medicine and technology the congress provides a comprehensive overview and in–depth, first-hand information on new developments, advanced technologies and current and future applications. With this Final Program we would like to give you an overview of the dimension of the congress and invite you to join us in Munich! Olaf Dössel Congress President Wolfgang C.