Metallomics and the Cell

Metallomics and the Cell
Author: Lucia Banci
Publisher: Springer Science & Business Media
Total Pages: 642
Release: 2013-04-18
Genre: Science
ISBN: 9400755619
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Metallomics and the Cell provides in an authoritative and timely manner in 16 stimulating chapters, written by 37 internationally recognized experts from 9 nations, and supported by more than 3000 references, several tables, and 110 illustrations, mostly in color, a most up-to-date view of the "metallomes" which, as defined in the "omics" world, describe the entire set of biomolecules that interact with or are affected by each metal ion. The most relevant tools for visualizing metal ions in the cell and the most suitable bioinformatic tools for browsing genomes to identify metal-binding proteins are also presented. Thus, MILS-12 is of relevance for structural and systems biology, inorganic biological chemistry, genetics, medicine, diagnostics, as well as teaching, etc.

Metallomics

Metallomics
Author: Yasumitsu Ogra
Publisher: Springer
Total Pages: 360
Release: 2017-03-01
Genre: Medical
ISBN: 4431564632
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This book focuses on recent topics in metallomics, a study of the metallome, or metal-containing biomolecules. Metals can induce various physiological and toxicological effects in a very small amounts, in other words, the concentrations of biometals are very low in organisms. Thus, analytical techniques for a trace amount of metal are crucial to understand the biological and toxicological functions of metals.This volume begins with an overview of metallomics including the history and development of the field. Subsequent parts provide basic and advanced techniques for metallomics. Speciation and imaging of metals are basic approaches to reveal the function of the metallome. The applications of speciation using an HPLC hyphenated with inductively coupled plasma mass spectrometry (LC-ICP-MS) and flow cytometry ICP-MS are described. As advanced approaches, the applications using a micro-flow injection-ICP-MS, an ICP-triple quadrupole mass spectrometer, an ICP-sector field mass spectrometer, and an ICP-multi-collector mass spectrometer are mentioned. For the imaging of metals, basic principles and applications of several techniques such as scanning X-ray fluorescence microscopy and ICP-MS equipped with laser ablation (LA-ICP-MS) are presented. Speciation analyses using electrospray ionization mass spectrometry (ESI-MS), X-ray Absorption Spectroscopy (XAS), and nuclear magnetic resonance spectroscopy (NMR) are also introduced. The last part highlights the medical and pharmaceutical applications of metallomics. Molecular biological approaches to reveal the effects of toxic metals, metal functions in brain and neurodegenerative diseases, and metallodrugs are explained. The topic of metal transporters is also presented.

Metallomics

Metallomics
Author: Marco Aurélio Zezzi Arruda
Publisher: Springer
Total Pages: 287
Release: 2018-06-08
Genre: Science
ISBN: 3319901435
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This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.

Metallomics

Metallomics
Author: Bernhard Michalke
Publisher: John Wiley & Sons
Total Pages: 496
Release: 2016-09-12
Genre: Science
ISBN: 3527694919
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Latest developments, new insights and knowledge derived from speciation analysis in one unique compilation: The reader gets acquainted with relevant instrumental as well as application aspects of metallomics approaches, paving the road to understanding fate, pathway, and action of metals in environment and organisms. Upon an introductory chapter on analytical methods and strategies, the full bandwidth of applications is discussed. Expert chapter authors cast spotlights on recent topics such as metallomics applications to environmental and nutrition studies as well as biology and medicine. Special chapters deal with the impact of manganese and iron on neurodegeneration, and the impact of nanoparticles on health.

Applied Metallomics

Applied Metallomics
Author: Yu-Feng Li
Publisher: John Wiley & Sons
Total Pages: 498
Release: 2024-08-12
Genre: Science
ISBN: 3527351442
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Applied Metallomics A groundbreaking survey of a field that unites the sciences The metallome of a cellular compartment, such as an enzyme, is the variety and arrangement of its metal ions. Metallomics is the multidisciplinary study of the metallome and its many important interactions with biological molecules and systems. It exists at the intersection of biochemistry and materials science, offering crucial insights into biological processes in which iron, for instance, plays a pivotal role. Applied Metallomics is an up-to-the-minute overview of research developments in metallomics, offering both analysis and applications in a vast array of scientific and industrial areas. Moving freely between material science, environmental science, health science, and more, it offers a comprehensive survey of this interdisciplinary research area. As the field of metallomics continues to develop and its applications expand, this book will only be a need of the hour Applied Metallomics readers will also find: Detailed treatment of nanometallomics, environmetallomics, agrometallomics, and many more Coverage of machine learning and artificial intelligence techniques with applications in metallomics An author team with vast international research experiences Applied Metallomics is ideal for researchers in many areas touched by metallomics, that include chemistry, biochemistry, biotechnology, bioinorganic chemistry, and more.

Metallomics: A Primer Of Integrated Biometal Sciences

Metallomics: A Primer Of Integrated Biometal Sciences
Author: Wolfgang Maret
Publisher: World Scientific Publishing Company
Total Pages: 157
Release: 2016-05-12
Genre: Science
ISBN: 1783268301
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Metallomics is an integrated biometal science as it unifies different disciplines into a mainstream subject that can be taught to students of the biological and biomedical sciences. Metallomics bridges chemistry and the biological sciences from a global and quantitative systems approach, while the biological context provides new insights into the functions of metals in biological cells. The book challenges the traditional view of relating biochemistry only to organic chemistry, and discusses the structure and function of metal ions in the context of their environment in organisms.This is an essential read for undergraduate and graduate students in the fields of biochemistry, cell biology, nutrition (trace element research), toxicology, pharmacology and ecology.

Nuclear Analytical Techniques for Metallomics and Metalloproteomics

Nuclear Analytical Techniques for Metallomics and Metalloproteomics
Author: Chunying Chen
Publisher: Royal Society of Chemistry
Total Pages: 428
Release: 2010
Genre: Science
ISBN: 1847559018
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Nuclear analytical techniques have many advantages over other techniques, such as high sensitivity and precision. They couple powerful selective separation with sensitive element-specific detection. The uses of metalloproteomics studies are restricted to the fields of analytical and nuclear chemistry. They also have great potential to elucidate the origins of certain diseases and assist in their diagnosis and treatment via the development of new drugs. Nuclear Analytical Techniques for Metallomics and Metalloproteomics provides readers with a comprehensive view of this relatively new and exciting area of bioanalytical and inorganic chemistry. It contains contributions from experts in disciplines as diverse as analytical chemistry, nuclear chemistry, environmental science, molecular biology and medicinal chemistry. Various nuclear analytical techniques are covered including neutron activation analysis, X-ray fluorescence, isotope tracer, M÷ssbauer spectrometry, X-ray absorption spectrometry, and neutron scattering and diffraction. They provide useful information both for chemical speciation analysis and structural characterization of metalloproteins and metals in biological systems. Consequently, the book is not only relevant for chemists involved in nuclear techniques and speciation, but also environmental, nutritional and clinical researchers and drug developers. The book includes many illustrations, tables and documents to support the coverage of the latest developments. It also offers a well-organized bibliography to facilitate further reading.

Metabolomics: From Fundamentals to Clinical Applications

Metabolomics: From Fundamentals to Clinical Applications
Author: Alessandra Sussulini
Publisher: Springer
Total Pages: 353
Release: 2017-01-28
Genre: Science
ISBN: 3319476564
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This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Trace Metals and Infectious Diseases

Trace Metals and Infectious Diseases
Author: Jerome O. Nriagu
Publisher: MIT Press
Total Pages: 501
Release: 2024-06-11
Genre: Medical
ISBN: 0262552485
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Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang

Agromining: Farming for Metals

Agromining: Farming for Metals
Author: Antony van der Ent
Publisher: Springer Nature
Total Pages: 482
Release: 2020-12-07
Genre: Technology & Engineering
ISBN: 3030589048
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This second and expanded edition of the first book on agromining (phytomining) presents a comprehensive overview of the metal farming & recovery of the agromining production chain. Agromining is an emerging technology that aims to transform the extraction of sources of target elements not accessible by traditional mining and processing techniques. Agromining, which is based on sustainable development, uses hyperaccumulator plants as 'metal crops' farmed on sub-economic soils or minerals wastes to obtain valuable target elements. This volume is edited and authored by the pioneers in the rapidly expanding field of agromining and presents the latest insights and developments in the field. This book provides in-depth information on the global distribution and ecology of hyperaccumulator plants, their biogeochemical pathways, the influence of rhizosphere microbes, the physiology and molecular biology of hyperaccumulation, as well as aspects of propagation and conservation of these unusual plants. It describes the agronomy of metal crops and opportunities for incorporating agromining into rehabilitation and mine closure, including test cases for agromining of nickel, cobalt, manganese, arsenic, selenium, cadmium, zinc, thallium, rare earth elements and platinum group elements. Since the first edition was published, there have successful nickel agromining field trials in the tropics (in Malaysia and Guatemala), and these are presented in a dedicated case study chapter. Other new chapters focus on the processing of bio-ore for elements other than nickel, such as rare earth elements and cadmium, and on agromining from industrial wastes such as tailings, and industrial by-products and sites. Furthermore, the book features two new chapters that provide a comprehensive assessment of accumulation a very wide range elements from the Periodic Table in various plant species around the globe, and a chapter on practical methods for discovery of hyperaccumulator plant species in the field and in the herbarium. This book is of interest to environmental professionals in the minerals industry, government regulators, and academics.