Medications for Opioid Use Disorder Save Lives

Medications for Opioid Use Disorder Save Lives
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 175
Release: 2019-06-16
Genre: Medical
ISBN: 0309486483

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The opioid crisis in the United States has come about because of excessive use of these drugs for both legal and illicit purposes and unprecedented levels of consequent opioid use disorder (OUD). More than 2 million people in the United States are estimated to have OUD, which is caused by prolonged use of prescription opioids, heroin, or other illicit opioids. OUD is a life-threatening condition associated with a 20-fold greater risk of early death due to overdose, infectious diseases, trauma, and suicide. Mortality related to OUD continues to escalate as this public health crisis gathers momentum across the country, with opioid overdoses killing more than 47,000 people in 2017 in the United States. Efforts to date have made no real headway in stemming this crisis, in large part because tools that already existâ€"like evidence-based medicationsâ€"are not being deployed to maximum impact. To support the dissemination of accurate patient-focused information about treatments for addiction, and to help provide scientific solutions to the current opioid crisis, this report studies the evidence base on medication assisted treatment (MAT) for OUD. It examines available evidence on the range of parameters and circumstances in which MAT can be effectively delivered and identifies additional research needed.

A Prescription for Alcoholics - Medications for Alcoholism

A Prescription for Alcoholics - Medications for Alcoholism
Author: Linda Burlison
Publisher:
Total Pages: 648
Release: 2016
Genre:
ISBN: 9780997107609

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There are FDA-approved drugs that treat alcoholism. It has been proven for decades, in hundreds of research studies conducted by leading scientists and scientific institutions that medications can safely reduce drinking, decrease cravings and lengthen abstinence in alcoholics. But those who desperately need these medications haven't been told about them. Until now. Finally, the first book about medication assisted treatment of alcoholism.Tools & Resources:* Everything you & your doctor need to know to start treatment with medication. * 100s of detailed pages of research findings on drugs shown to help fight alcoholism. * Answers to important questions on safety, liver toxicity, side effects, dosage & more Learn About:* Effective medications such as: acamprosate, baclofen, topiramate, naltrexone, nalmefene, gabapentin, ondansetron, varenicline, disulfiram, prazosin, zonisamide, olanzapine, sertraline and more. * Why 12-step programs are not supported by 21st-century evidence-based medicine; and why doctors prescribe it anyway.New Insights:* Several popular antidepressants may increase drinking in some alcoholics.* How alcoholism erodes the neurocircuitry of self-control* Why treatment with medication should be a first step - not the last resort.Goals:* why reduction or abstinence are both medically supported options. Evidence Based:* Based on the work of the world's top addiction research scientists.

Doctors and 'dopefiends'

Doctors and 'dopefiends'
Author: John Christian Foerster
Publisher:
Total Pages: 95
Release: 2020
Genre:
ISBN:

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This article examines the socio-political intricacies of the United States Opiate Crisis. By first addressing the pharmaceutical origins of Oxycontin and its pain relief benefits within the United States, I construct a framework by which a conversation about substance abuse can move forward. Within the first chapter I provide background into the arguments for medicalization against personal responsibility as it relates to opiate withdrawal and seeking treatment for the prior. Furthermore, I include subheadings to further provide insight into Medically Assisted Treatment Centers and their function on the local level. I contrast these modern treatment models with the Reagan War on Drugs mentalities and illustrate a larger societal tonal shift towards increased medicalization. My second chapter addresses the bulk of my theoretical frameworks, including spatial and feminist theories to construct an argument about patriarchal dominance in relation to factors such as homelessness, race, and socioeconomic status. Finally, in my third chapter I examine the current debate regarding whether or not the U.S. Opiate Crisis can truly be considered a crisis. I address the arguments for why it could still be considered a widespread crisis, and end on the central argument for the crisis being a symptom of Disease of Despair.

Pain Management and the Opioid Epidemic

Pain Management and the Opioid Epidemic
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 483
Release: 2017-09-28
Genre: Medical
ISBN: 0309459575

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Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Molecular Therapeutics

Molecular Therapeutics
Author: Pamela Greenwell
Publisher: John Wiley & Sons
Total Pages: 264
Release: 2008-03-11
Genre: Science
ISBN: 9780470725146

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"This book should be useful to lecturers who teach senior undergraduates, graduate students, and students in the biomedical sciences in general. More globally, Greenwell and McCulley's book should encourage academicians of any stripe who for some time have been honing their lectures in a niche subject area to turn their courses into textbooks." –Biochemistry and Molecular Biology Education Molecular therapeutics refers to the developments in molecular biology that are focused on treating disease with new molecular-based drugs. By taking advantage of recent advances and increased understanding in the field of human genetics, this book provides essential background knowledge and key literature on a broad range of novel approaches and disciplines. These include making recombinant proteins, xenotransplantation gene therapy and therapeutic cloning. Molecular Therapeutics: 21st Century Medicine describes the techniques - including their associated benefits, problems, pitfalls - and discusses their applicability with respect to treating microbial, inherited, multifactoral and acquired diseases. The book also pays specific attention to the ethical issues associated with this new field. Cutting-edge topics and clinically relevant materials engage and maintain student interest Self-assessment questions are included throughout the book Features an additional web site, with a web forum, regular updates and PowerPoint slides of figures from the book Molecular Therapeutics: 21st Century Medicine is a comprehensive, accessible and engaging guide to the rapidly developing field of molecular therapeutics. It is essential reading for all students in this area of research and also of interest for health professionals involved in these novel therapies.

The Cure in the Code

The Cure in the Code
Author: Peter W Huber
Publisher: Basic Books
Total Pages: 306
Release: 2013-11-12
Genre: Law
ISBN: 0465069819

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Never before have two revolutions with so much potential to save and prolong human life occurred simultaneously. The converging, synergistic power of the biochemical and digital revolutions now allows us to read every letter of life's code, create precisely targeted drugs to control it, and tailor their use to individual patients. Cancer, diabetes, Alzheimer's and countless other killers can be vanquished -- if we make full use of the tools of modern drug design and allow doctors the use of modern data gathering and analytical tools when prescribing drugs to their patients. But Washington stands in the way, clinging to outdated drug-approval protocols developed decades ago during medicine's long battle with the infectious epidemics of the past. Peter Huber, an expert in science, technology, and public policy, demonstrates why Washington's one-size-fits-all drug policies can't deal with diseases rooted in the complex molecular diversity of human bodies. Washington is ill-equipped to handle the torrents of data that now propel the advance of molecular medicine and is reluctant to embrace the statistical methods of the digital age that can. Obsolete economic policies, often rationalized as cost-saving measures, stifle innovation and suppress investment in the medicine that can provide the best cures at the lowest cost. In the 1980s, an AIDS diagnosis was a death sentence, until the FDA loosened its throttling grip and began streamlining and accelerating approval of life-saving drugs. The Cure in the Code shows patients, doctors, investors, and policy makers what we must now do to capture the full life-saving and cost-saving potential of the revolution in molecular medicine. America has to choose. At stake for America is the power to lead the world in mastering the most free, fecund, competitive, dynamic, and intelligent natural resource on the planet -- the molecular code that spawns human life and controls our health.

Applying Big Data to Address the Social Determinants of Health in Oncology

Applying Big Data to Address the Social Determinants of Health in Oncology
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
Total Pages: 83
Release: 2020-08-14
Genre: Medical
ISBN: 0309679060

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The National Academies of Sciences, Engineering, and Medicine held the workshop Applying Big Data to Address the Social Determinants of Health in Oncology on October 28â€"29, 2019, in Washington, DC. This workshop examined social determinants of health (SDOH) in the context of cancer, and considered opportunities to effectively leverage big data to improve health equity and reduce disparities. The workshop featured presentations and discussion by experts in technology, oncology, and SDOH, as well as representatives from government, industry, academia, and health care systems. This publication summarizes the presentations and discussions from the workshop.