In this issue of Dental Clinics, guest editors Drs. Mel Mupparapu and Andres Pinto bring their considerable expertise to the topic of Clinical Decisions in Medically Complex Dental Patients. This issue is Part 1 of a practical guide to an essential area of clinical practice. Dozens of commonly encountered patient scenarios are provided and discussed by experts in the field, highlighted by easy-to-follow flow charts, tables, and images. Coverage of potentially significant conditions helps dentists protect and safely treat patients with a medical complexity or during a medical emergency. Contains 42 patient scenarios including a patient with a pacemaker, history of stroke, and stent placement presenting for extraction of the lower molar; a patient with a history of COPD, ischemic heart disease, and cardiac arrhythmia presenting for restorative treatment; an adolescent with poorly managed asthma referred for pulp therapy in a permanent tooth; a patient with severe dental anxiety and episodes of fainting in need of dental restoration; and more. Provides in-depth clinical reviews on clinical decisions in medically complex dental patients, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.