Cell Therapy for Perinatal Brain Injury

Cell Therapy for Perinatal Brain Injury
Author: Haruo Shintaku
Publisher: Springer
Total Pages: 155
Release: 2018-03-01
Genre: Medical
ISBN: 9811014124

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This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.

Muse Cells

Muse Cells
Author: Mari Dezawa
Publisher: Springer
Total Pages: 315
Release: 2018-11-27
Genre: Medical
ISBN: 4431568476

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This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.

Fetal and Neonatal Brain Injury

Fetal and Neonatal Brain Injury
Author: David Kendal Stevenson
Publisher: Oxford University Press, USA
Total Pages: 696
Release: 1997
Genre: Family & Relationships
ISBN:

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This book evaluates the numerous events in pregnancy, labor, and post-partum care that can lead to brain damage in newborn infants. The mechanisms by which the brain is damaged, as well as the approaches to treatment and most importantly, prevention of injury are detailed. Sixteen new chapters have been added to the Second Edition, and all the others have been fully updated. New chapters cover subjects such as ischemic cell injury, reperfusion injury, experimental models of perinatal brain injury, hypoxemic-ischemic encephalopathy, congenital malformations of the brain, perinatal infections, and metabolic disorders in the developing CNS. A chapter devoted exclusively to hemorrhagic lesions of the brain has been added as well. The new edition incorporates the most recent advances in neurology, neurosurgery, and neuroimaging, including the rapidly improving imaging techniques for identifying the extent of brain injury, the better ante- and post-partum management of infants, and the development of better understanding of the cellular mechanism of injuries to the brain.

The Newborn Brain

The Newborn Brain
Author: Hugo Lagercrantz
Publisher: Cambridge University Press
Total Pages: 427
Release: 2010-01-07
Genre: Medical
ISBN: 113948558X

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Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.