Paraquat Poisoning

Paraquat Poisoning
Author: Chantal Bismuth
Publisher: Marcel Dekker
Total Pages: 362
Release: 1995
Genre: Medical
ISBN: 9780824793708

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This volume offers in-depth coverage of all important aspects of human paraquat poisoning, providing recent information on everything from the basic science of liquid peroxidation, to recent recommendations for prevention, diagnosis, prognosis and treatment. Perspectives from developed and developing countries are given. This work is intended for: medical and clinical toxicologists, organic, medicinal, agricultural and herbicide chemists; poison information specialists; public health, regulatory compliance and risk management officers; sanitarians; industrial hygienists; ecologists; and graduate-level and continuing-education students in these disciplines.

Biochemical Mechanisms of Paraquat Toxicity

Biochemical Mechanisms of Paraquat Toxicity
Author: Anne Pomeroy Autor
Publisher: Elsevier
Total Pages: 250
Release: 2012-12-02
Genre: Medical
ISBN: 0323159079

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Biochemical Mechanisms of Paraquat Toxicity presents the proceedings of the First Iowa Symposium on Toxic Mechanisms that was held from June 28-29, 1976. The symposium brought together a diverse group of investigators consisting of chemists, pharmacologists, pathologists, biochemists, and toxicologists from the United States, Canada, and Europe who have been interested in the mechanism of paraquat toxicity. The book includes papers on the following topics: the general features of toxic lung injury and observations with paraquat and diquat; electron transfer reactions of paraquat; the pathological effects of paraquat on the human lung; and the importance of oxygen and pulmonary alveolar surfactant in lung injury by paraquat. Other papers deal with the effects of paraquat on kidney and liver function in experimental animals; lipid peroxidation as a proposed mechanism for paraquat toxicity; pulmonary fibrosis as a consequence of paraquat toxicity; biochemical changes in lungs exposed to paraquat; effects of selenium deficiency on paraquat toxicity; and treatment for paraquat poisoning.

Biochemical Mechanisms of Paraquat Toxicity

Biochemical Mechanisms of Paraquat Toxicity
Author: Iowa Symposium on Toxic Mechanisms$ (1er : 1976 : Iowa City)
Publisher:
Total Pages: 240
Release: 1977
Genre:
ISBN:

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Paraquat and Diquat

Paraquat and Diquat
Author:
Publisher:
Total Pages: 181
Release: 1984
Genre:
ISBN:

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Development of Cobinamide as a Potential Antidote for Paraquat Poisoning

Development of Cobinamide as a Potential Antidote for Paraquat Poisoning
Author: Cassandra Lai
Publisher:
Total Pages: 34
Release: 2019
Genre:
ISBN:

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Paraquat is a commonly used herbicide that is highly toxic when ingested and has been increasingly used in suicide cases. No effective treatment for paraquat poisoning exists. There are two mechanisms of paraquat toxicity: the production of reactive oxygen species like superoxide and the inhibition of mitochondrial respiration. Cobinamide, the vitamin B12 precursor, has been shown to be an effective scavenger of reactive oxygen species (ROS). Due to cobinamide's ability to scavenge ROS, we hypothesized that cobinamide could be used as a potential treatment for paraquat poisoning. We tested the hypothesis by assessing cobinamide's effectiveness in reversing paraquat-induced toxicity in vitro and in vivo. Experiments with mammalian cells and Drosophila melanogaster showed that cobinamide partially rescued these model organisms from paraquat toxicity. Further experiments were performed to determine the mechanism of this rescue. The production of ATP was assessed in COS7 cells showing a dose-dependent decrease in ATP levels in response to paraquat, but surprisingly, was not restored upon addition of cobinamide. Mechanistically, this is maybe due to the lack of binding between cobinamide and paraquat. Results suggest that the mechanism of antagonism occurs mainly through ROS scavenging. Overall, these findings suggest the potential use of cobinamide as an antidote for paraquat poisoning in the clinical setting.

Mixture Toxicity

Mixture Toxicity
Author: Cornelis A. M. van Gestel
Publisher: CRC Press
Total Pages: 312
Release: 2016-04-19
Genre: Medical
ISBN: 1439830096

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In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

Biomarkers in Toxicology

Biomarkers in Toxicology
Author: Ramesh C Gupta
Publisher: Academic Press
Total Pages: 1149
Release: 2014-01-25
Genre: Technology & Engineering
ISBN: 0124046495

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Biomarkers in Toxicology is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This book includes both vertebrate and non-vertebrate species models for toxicological testing and development of biomarkers. Divided into several key sections, this reference volume contains chapters devoted to topics in molecular-cellular toxicology, as well as a look at the latest cutting-edge technologies used to detect biomarkers of exposure and effects. Each chapter also contains several references to the current literature and important resources for further reading. Given this comprehensive treatment, Biomarkers in Toxicology is an essential reference for all those interested in biomarkers across several scientific and biomedical fields. Written by international experts who have evaluated the expansive literature to provide you with one resource covering all aspects of toxicology biomarkers Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure and effect of chemicals of different classes Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation and much more

Movement Disorders

Movement Disorders
Author: Mark S. LeDoux
Publisher: Elsevier
Total Pages: 821
Release: 2005-01-25
Genre: Science
ISBN: 0080470564

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The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders. * Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to* Includes contributions by expert movement disorder clinicians and top-level researchers in the field* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models