This textbook introduces powerful computational software tool called MATLAB. The main objective of this book is to expose the readers to MATLAB features that integrate computation, visualization and programming in an easy-to-use environment. This book covers built-in functions of MATLAB, commands and their applications in topics of mathematical physics and engineering mathematics. The book is written in a very simple language and chapters are arranged sequentially. Each topic covered in this book, has its corresponding theoretical explanation prior to its MATLAB execution. The authors explain concepts with the help of screenshots of the MATLAB software and programming codes with their outputs. This approach not only creates a direct link between the book and the MATLAB software but also imbibes the feeling of actual interaction with MATLAB software. A sufficient number of examples based on MATLAB programming codes have been worked out so that students can grasp the concepts, the ideas, and the results in an easy way. At the end of each chapter, students will have a chance to answer several application-based questions in exercise. All these features make this book to be used as a textbook for theoretical learning as well as for laboratory course. The book is suitable for the undergraduate and postgraduate students of mathematics, physics, instrumentation and electronics. The undergraduate students of engineering will also find this book useful.