The benefit of an adequate framework for the management of animal health emergency operations has been repeatedly shown over the years, highlighting a need to build and upgrade capabilities to effectively and efficiently manage animal health emergency operations at all levels. This need can begin to be met through the guidance provided in this manual. Equipped with practical examples, samples and guidelines, this manual supports countries and relevant local, national, regional and international organizations as they prepare for and manage operations during an animal health emergency. The manual is designed to be used in line with the 'Good Emergency Management Practice: The Essentials' manual, applying Good Emergency Management Practice (GEMP) principles and a One Health approach, and providing a global view of how to act during the peacetime and emergency phases of animal health events. This global manual is presented in such a way that veterinary services and relevel local authorities in countries around the world can use the information therein as guidance to create or adapt their own systems, and build a customized emergency operations management manual.