In this issue of Emergency Medicine Clinics, guest editors Drs. C Cheyenne Falat and Stephanie Lareau bring their considerable expertise to the topic of Environmental and Wilderness Medicine. Emergency medicine physicians must be equipped with the knowledge to effectively care for patients who push the limits of this world and are exposed to the extremes of temperature, altitude, terrain, physical activity, flora and fauna—and even outer space. This issue addresses each of these topics with guidance from top experts in the field. Contains 15 relevant, practice-oriented topics including altitude related conditions; dive related illness and injury; desert medicine; endurance sporting events; tick borne diseases; climate change; space medicine; and more. Provides in-depth clinical reviews on environmental and wilderness medicine, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.