Lung Development

Lung Development
Author: Claude Gaultier
Publisher: Springer
Total Pages: 464
Release: 2013-05-27
Genre: Medical
ISBN: 1461475376
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Knowledge about the mechanisms of lung development has been growing rapidly, especially with regard to cellular and molecular aspects of growth and differentiation. This authoritative international volume reviews key aspects of lung development in health and disease by providing a comprehensive review of the complex series of cellular and molecular interactions required for lung development. It covers such topics as pulmonary hypoplasia, effects of malnutrition, and pulmaonary angiogenesis. An indispensable reference for all those involved in studying or treating lung disease in neonates and children, the book offers a unique view of the development of this essential organ.

The Lung

The Lung
Author: Kent Pinkerton
Publisher: Elsevier
Total Pages: 533
Release: 2014-10-23
Genre: Science
ISBN: 0128002883
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The second edition of The Lung: Development, Aging and the Environment provides an understanding of the multi-faceted nature of lung development, aging, and how the environment influences these processes. As an essential resource to respiratory, pulmonary, and thoracic scientists and physicians it provides an interface between the “normal and “disease cluster of chapters, allowing for a natural complement to each other. The interface between different lung diseases affecting the pediatric lung also adds a useful source for comparing how different lung diseases share key pathophysiological features. This same complementarity comes across in the logical line up of chapters dealing with the “normal pediatric lung. New research, including cell-based strategies for infant lung function, epigenetics, and prenatal alcohol exposure on lung development and function are some of the important additions to this edition of this reference work. Describes the normal processes of lung development, growth and aging Considers the effects of the environmental contaminants in the air, water, soil, and diet on lung development, growth and health Describes genetic factors involved in susceptibility to lung disease Covers respiratory health risk in children

Fetal and Neonatal Lung Development

Fetal and Neonatal Lung Development
Author: Alan H. Jobe
Publisher: Cambridge University Press
Total Pages:
Release: 2016-04-18
Genre: Medical
ISBN: 1316665178
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Lung disease affects more than 600 million people worldwide. While some of these lung diseases have an obvious developmental component, there is growing appreciation that processes and pathways critical for normal lung development are also important for postnatal tissue homeostasis and are dysregulated in lung disease. This book provides an authoritative review of fetal and neonatal lung development and is designed to provide a diverse group of scientists, spanning the basic to clinical research spectrum, with the latest developments on the cellular and molecular mechanisms of normal lung development and injury-repair processes, and how they are dysregulated in disease. The book covers genetics, omics, and systems biology as well as new imaging techniques that are transforming studies of lung development. The reader will learn where the field of lung development has been, where it is presently, and where it is going in order to improve outcomes for patients with common and rare lung diseases.

Lung Stem Cells in Development, Health and Disease

Lung Stem Cells in Development, Health and Disease
Author: Nikolic, Marko Z.
Publisher: European Respiratory Society
Total Pages: 395
Release: 2021-04-01
Genre: Medical
ISBN: 1849841349
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Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science

How Tobacco Smoke Causes Disease

How Tobacco Smoke Causes Disease
Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
Total Pages: 728
Release: 2010
Genre: Government publications
ISBN:
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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Spencer's Pathology of the Lung

Spencer's Pathology of the Lung
Author: Philip Hasleton
Publisher: Cambridge University Press
Total Pages: 4616
Release: 2013-01-17
Genre: Medical
ISBN: 1139618970
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Fully rewritten and updated for the cutting-edge sixth edition, Spencer's Pathology of the Lung follows in its predecessors' footsteps as the gold-standard textbook of pulmonary diseases. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations. Downloadable versions of all images are available on a CD-ROM packaged with the print book. Written and edited by leading experts in the field, this is an essential resource for practising and trainee pathologists.

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension

Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension
Author: Toshio Nakanishi
Publisher: Springer Nature
Total Pages: 374
Release: 2020-02-28
Genre: Medical
ISBN: 9811511853
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This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.

Neonatal Respiratory Distress

Neonatal Respiratory Distress
Author: Philip M Farrell
Publisher: Academic Press
Total Pages: 334
Release: 2013-09-03
Genre: Medical
ISBN: 1483269124
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Lung Development: Biological and Clinical Perspectives, Volume II: Neonatal Respiratory Distress is a collection of papers that addresses the needs of small infants who have respiratory diseases. This volume deals with fetal lung development with emphasis on hyaline membrane disease. This book also presents basic information on pulmonary surfactant in the clinical area, particularly in 1) diagnosis and movement of neonatal respiratory distress; 2) prenatal assessment of fetal lung maturity; and 3) prevention of hyaline membrane disease with corticosteroid therapy. One paper reviews the essential clinical aspects of hyaline membrane disease, while another paper discusses data of the physiology of surfactant from a patient with hyaline membrane disease. Another paper examines the radiology of hyaline membrane disease, transient tachypnea of the newborn, and bronchopulmonary dysplasia; this paper also describes the radiographic techniques to be applied on infants. Other papers cite a treatment using antepartum glucocorticoid, as well as other clinical trials involving antenatal corticosteroid. One paper proposes a design and organization of a multicenter clinical trial that will study the effects of corticosteroid in the development of the human lung. This book can prove useful for pediatricians, specialists in respiratory diseases, and researchers whose work involves cardiovascular medicine and radiology.

Lung Development Biological and Clinical Perspectives

Lung Development Biological and Clinical Perspectives
Author: Philip Farrell
Publisher: Elsevier
Total Pages: 434
Release: 2012-12-02
Genre: Health & Fitness
ISBN: 0323150462
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Lung Development: Biological and Clinical Perspectives: Biochemistry and Physiology, Volume I, provides a comprehensive and multidisciplinary treatise with regard to surfactant-related issues in lung maturation. Despite the deliberate emphasis on biochemistry in this volume, the aim is to place this information in the perspective of anatomy, physiology, and clinical perinatology. The book is organized into four parts. Part I offers a brief historical perspective by reviewing the chronology of clinical and basic advances. Part II then establishes a frame of scientific reference by reviewing the morphology and cytology of lung development and the physiology of pulmonary surfactant. Stages of development and variations in the maturation process are emphasized, while cautions to the biochemist are offered with respect to interpretation of experimental data. Part III provides an introduction to lung biochemistry. Part IV deals with the developmental biochemistry of lung phospholipid metabolism; the featured compound is the predominant surfactant component, phosphatidylcholine (PC). A focal point for discussion concerns regulatory mechanisms operating to control the production of saturated PC during late gestational development of the fetal lung.

The Newborn Lung

The Newborn Lung
Author: Eduardo Bancalari
Publisher: Elsevier Health Sciences
Total Pages: 464
Release: 2018-06-19
Genre: Medical
ISBN: 0323568750
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Dr. Richard Polin’s Neonatology Questions and Controversies series highlights the most challenging aspects of neonatal care, offering trustworthy guidance on up-to-date diagnostic and treatment options in the field. In each volume, renowned experts address the clinical problems of greatest concern to today’s practitioners, helping you handle difficult practice issues and provide optimal, evidence-based care to every patient. Stay fully up to date in this fast-changing field with The Newborn Lung, 3rd Edition. The most current clinical information throughout, including key management strategies that may reduce some of the chronic sequelae of neonatal respiratory failure. New content on the role of microbiome in lung injury and lung development. Current coverage of non-invasive respiratory support, perinatal events and their influence on lung development and injury, cell-based lung therapy, automation of respiratory support, and oxygenation targeting in preterm infants. Consistent chapter organization to help you find information quickly and easily. The most authoritative advice available from world-class neonatologists who share their knowledge of new trends and developments in neonatal care. Purchase each volume individually, or get the entire 7-volume set! Gastroenterology and Nutrition Hematology, Immunology and Genetics Hemodynamics and Cardiology Infectious Disease and Pharmacology New Volume! Nephrology and Fluid/Electrolyte Physiology Neurology The Newborn Lung