The book represents a critical update on interactions between the host and its gut microbiome that conditions the socio-biology of the mind and behaviour. Evidence has been scientifically approached and reveals that our conscious behaviour involves a complex interplay of multiple non-conscious domains, including complex host-gut microbiome relationships. The book describes trends and issues on which there is increasing evidence of the impact of host-gut microbiome interactions on behaviour and cultural construction of self-perception. This suggests the need to re-evaluate traditional, basic concepts of human development. Additionally, it calls attention to open issues involving conceptual themes on neurobiological integration and its impact on early developmental and social domains on the typical extended period of human postnatal helplessness during which the basic scaffolding of mental development is completed. It also deals with the impact of poverty and inadequate early feeding habits on individual cognitive development, performance, and social construction. It discusses the need to reformulate views and policies on social marginalisation, child poverty, and malnutrition involving host-gut microbiome imbalances. The spectrum of possible behaviours in all species and its plasticity depends on an integrated vector of basic components involving the genetic code, social and physical environmental, developmental conditions, the relative condition of dominance or submission in social settings –or prey/predator in the Natural Kingdom– and on its physiological and anatomical construction profiles. Graduate, postgraduate and teachers interested in areas connected with anthropology, social medicine, early education, and health policymakers will benefit greatly from this book.