Lessons from Animal Diabetes VI

Lessons from Animal Diabetes VI
Author: Eleazar Shafrir
Publisher: Springer Science & Business Media
Total Pages: 427
Release: 2012-12-06
Genre: Medical
ISBN: 146124112X

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Genic constructs. Five articles are devoted to this topic ranging from the B-cell function in transgenic animals to the various effects on diabetes complications. The section on NIDDM, comprising of 10 articles, deals both with new and existing models, their particular widely varying pathogenesis, genetic character istics and complications. The animals reviewed include: spontaneously diabetic OLETF rats, Chinese hamsters, Goto-Kakizaki rats, db/db mice, rhesus monkeys, dogs and an article demonstrating the genetic link between the Zucker fa/fa and corpulent cp/cp obese interstrains. We wish to welcome the new members to our Editorial Board, Dr. Hubert Kolb from Dusseldorf, Dr. Alex Rabinovitch from Edmonton, Dr. Takayoshi Toyota from Sendai and Dr. Soroku Yagihashi from Hirosaki. At the same time we would like to thank Dr. Douglas L. Coleman from Bar Harbor and Dr. George Eisenbarth from Denver for their editorial contribution to the previous LAD Vol umes who have retired from the Editorial Board. With great sadness we have to mention Dr. Otho Michaelis IV from Beltsville, MD who suddenly passed away this year. Otho, or Mike as he was called by friends, made a significant contribution in developing and metabolically defin ing several strains of corpulent cp rats and was extremely helpful in the editor ial work of the LAD series. His contribution will remain in a lasting memory of all researchers of animal diabetes.

Lessons from Animal Diabetes

Lessons from Animal Diabetes
Author: Eleazar Shafrir
Publisher: Food & Nutrition Press
Total Pages: 818
Release: 1984-01-01
Genre: Diabetes
ISBN: 9780861960323

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Experimental Models of Diabetes

Experimental Models of Diabetes
Author: John H. McNeill
Publisher: Routledge
Total Pages: 436
Release: 2018-05-11
Genre: Medical
ISBN: 1351449206

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An extremely useful text for research Internationally renowned experts describe the models, provide data obtained with those models, and discuss the relative usefulness of models in relation to the diabetic syndrome in humans. The first section examines the most widely used model, the streptozotocin (STZ) rat, condensing a massive quantity of literature to present both the general effects of of STZ diabetes and the effects on individual organ systems. The second section discusses less well-known and more recent diabetic models, such as the BB rat, the NOD mouse and Zucker and Zucker Diabetic Fatty rat models. Genetic models of insulin dependent diabetes mellitus (IDDM) are examined and compared to chemically induced IDDM models.

Lessons from Animal Diabetes III

Lessons from Animal Diabetes III
Author: Eleazar Shafrir
Publisher:
Total Pages: 682
Release: 1991
Genre: Diabetes
ISBN: 9781854630599

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Joslin's Diabetes Mellitus

Joslin's Diabetes Mellitus
Author: Elliott Proctor Joslin
Publisher: Lippincott Williams & Wilkins
Total Pages: 1244
Release: 2005
Genre: Medical
ISBN: 9780781727969

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The "bible" on diabetes mellitus is now in its Fourteenth Edition—thoroughly revised and updated by more than 80 noted experts from the Joslin Diabetes Center and other leading institutions worldwide. This edition includes a new eleven-chapter section on hormone action and the regulation of metabolism. The section on definition and pathogenesis now includes chapters on genetics, diabetes in Asia and Africa, and diabetes in U.S. minority groups. Other new chapters cover retinopathy, cardiovascular disease, wound healing, and treatment of women with diabetes. All of the Fourteenth Edition's figures have been completely updated.

Molecular Pathology of Type 1 Diabetes Mellitus

Molecular Pathology of Type 1 Diabetes Mellitus
Author: Matthias G. Von Herrath
Publisher: Karger Medical and Scientific Publishers
Total Pages: 371
Release: 2001-01-01
Genre: Medical
ISBN: 3805572409

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Type 1 diabetes as well as multiple sclerosis are thought to be T cell mediated autoimmune diseases that involve a detrimental action of inflammatory cytokines and autoaggressive T lymphocytes. They still pose many unsolved puzzles, and the precise etiology as well as prevention have remained elusive. It is clear that genetic factors can predispose for developing diabetes, however, based on significant disease discordance found in monozygotic twins, additional environmental factors have to be postulated. Viruses are good candidates because they induce strong cellular and humoral immune responses, but no single etiologic agent has been identified. Several animal models are presented which have been used to study the activation of naive autoreactive lymphocytes. It is shown that regulation of the autoaggressive process occurs prior to clinical diabetes and is mediated by a complete network of cytokines, as well as regulatory circuits/cells. The spreading of autoimmunity to self-antigens not involved in the initial phase of islet destruction is not necessarily detrimental and can carry benefits. Therapeutically, counter-regulation of aggressive responses has been demonstrated via various means in animal models preventing diabetes or rejection of transplanted islets.

Organtransplantation in Rats and Mice

Organtransplantation in Rats and Mice
Author: Wolfgang Timmermann
Publisher: Springer Science & Business Media
Total Pages: 655
Release: 2012-12-06
Genre: Medical
ISBN: 3642721400

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Main focus of the new book will be the description and discussion of rat and mouse models for organ transplantation. Various microsurgical techniques will be presented which allow transplantation of functional organs in syngeneic systems. In particular, the extremely difficult methods necessary for organ transplantation in mice will be presented and evaluated. Besides these practical aspects the book will also cover the theoretical sides of organ transplantation like the immunobiology of allotransplantation. Special emphasis will be given to the resurgent field of xenotransplantation. The results from xenograft models developed in the recent years using rats or mice will be reviewed and their impact on future human xenotransplantation will be discussed.

Cyclic ADP-Ribose and NAADP

Cyclic ADP-Ribose and NAADP
Author: Hon Cheung Lee
Publisher: Springer Science & Business Media
Total Pages: 462
Release: 2012-12-06
Genre: Medical
ISBN: 1461502691

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In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A wide range of physiological functions are now known to be mediated by them in cells spanning three biological kingdoms from protist, plant to animal. This is the first book devoted entirely to the field. The story behind the emergence of the field is told and followed by comprehensive reviews of the enzymology, regulations and gene structures of ADP-ribosyl cyclases responsible for metabolizing cADPR and NAADP. Also covered is some of the current methodology developed for and widely used in the field. The rest of the book focuses on and details the Ca2+ signaling mechanisms and specific physiological functions of these two messengers in various cellular systems.