Estimation of unknown parameters is considered as one of the major research areas in statistical signal processing. In the most recent decades, approaches in estimation theory have become more and more attractive in practical applications. Examples of such applications may include, but are not limited to, positioning using various measurable radio signals in indoor environments, self-navigation for autonomous cars, image processing, radar tracking and so on. One issue that is usually encountered when solving an estimation problem is to identify a good system model, which may have great impacts on the estimation performance. In this thesis, we are interested in studying estimation problems particularly in inferring the unknown positions from noisy radio signal measurements. In addition, the modeling of the system is studied by investigating the relationship between positions and radio signal strength measurements. One of the main contributions of this thesis is to propose a novel indoor positioning framework based on proximity measurements, which are obtained by quantizing the received signal strength measurements. Sequential Monte Carlo methods, to be more specific particle filter and smoother, are utilized for estimating unknown positions from proximity measurements. The Cramér-Rao bounds for proximity-based positioning are further derived as a benchmark for the positioning accuracy in this framework. Secondly, to improve the estimation performance, Bayesian non-parametric modeling, namely Gaussian processes, have been adopted to provide more accurate and flexible models for both dynamic motions and radio signal strength measurements. Then, the Cramér-Rao bounds for Gaussian process based system models are derived and evaluated in an indoor positioning scenario. In addition, we estimate the positions of stationary devices by comparing the individual signal strength measurements with a pre-constructed fingerprinting database. The positioning accuracy is further compared to the case where a moving device is positioned using a time series of radio signal strength measurements. Moreover, Gaussian processes have been applied to sports analytics, where trajectory modeling for athletes is studied. The proposed framework can be further utilized to carry out, for instance, performance prediction and analysis, health condition monitoring, etc. Finally, a grey-box modeling is proposed to analyze the forces, particularly in cross-country skiing races, by combining a deterministic kinetic model with Gaussian process.